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The purpose of this study was to assess the utility of quantitative imaging markers to distinguish ASC from AIH in paediatrics. 66 participants (N\u2009=\u200952 AIH, N\u2009=\u200914 ASC) aged 14.4\u2009\u00b1\u20093.3\u00a0years scheduled to undergo routine biopsy and baseline serum liver biochemistry testing were invited to undergo MRI (non-contrast abdominal MRI and 3D fast spin-echo MRCP). Multiparametric MRI was used to measure fibro-inflammation with corrected T1 (cT1), while the\u00a0biliary tree was modelled \u00a0 using quantitative MRCP (MRCP\u2009+). Mann\u2013Whitney U tests were performed to compare liver function tests with imaging markers between patient groups (ASC vs AIH). Receiver operating characteristic curves and stepwise logistic regressions were used to identify the best combination of markers to discriminate between ASC and AIH. Correlations between liver function tests and imaging markers were performed using Spearman\u2019s rank correlation. cT1 was significantly correlated with liver function tests (range 0.33\u2009\u2264\u2009R\u2009\u2264\u200956, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), as well as with fibrosis, lobular and portal inflammation (range 0.31\u2009\u2264\u2009R\u2009\u2264\u200942, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). 19 MRCP\u2009+\u2009metrics correlated significantly with liver function tests (range 0.29\u2009\u2264\u2009R\u2009\u2264\u20090.43, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). GGT and MRCP\u2009+\u2009metrics were significantly higher in ASC compared to those with AIH. The best multivariable model for distinguishing ASC from AIH included total number of ducts and the sum of relative severity of both strictures and dilatations AUC: 0.91 (95% CI 0.78\u20131). Quantitative MRCP metrics are a good discriminator of ASC from AIH.<\/jats:p>","DOI":"10.1038\/s41598-021-94754-9","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T10:02:50Z","timestamp":1627380170000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Quantitative multiparametric MRI as a non-invasive stratification tool in children and adolescents with autoimmune liver disease"],"prefix":"10.1038","volume":"11","author":[{"given":"Kamil","family":"Janowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Shumbayawonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Langford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Dennis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Pronicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wieslawa","family":"Grajkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Wozniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Pawliszak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Che\u0142stowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzbieta","family":"Jurkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajarshi","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Socha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"94754_CR1","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1016\/S0140-6736(12)62163-1","volume":"382","author":"MA Heneghan","year":"2013","unstructured":"Heneghan, M. 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Perspectum Ltd. is a privately funded commercial enterprise that develops medical devices to address unmet clinical needs, including LiverMultiScan.  Perspectum is the sponsor of this study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"15261"}}