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However, the relationship of the classification and severity\u00a0of HF with CI-AKI remains under-explored. From January 2009 to April 2019, we recruited patients undergoing elective PCI who had complete pre- and post-operative creatinine data. According to the levels of ejection fraction (EF), HF was classified as HF with reduced EF (HFrEF) [EF\u2009&lt;\u200940%], HF with mid-range EF (HFmrEF) [EF 40\u201349%] and HF with preserved EF (HFpEF) [EF\u2009\u2265\u200950%]. CI-AKI was defined as an increase of either 25% or 0.5\u00a0mg\/dL (44.2 \u03bcmoI\/L) in serum baseline creatinine level within 72\u00a0h following the administration of the contrast agent. A total of 3848 patients were included in the study; mean age 67\u00a0years old, 33.9% females, 48.1% with HF, and 16.9% with CI-AKI. In multivariate logistic regression analysis, HF was an independent risk factor for CI-AKI (OR 1.316, <jats:italic>p<\/jats:italic> value\u2009&lt;\u20090.05). Among patients with HF, decreased levels of EF (OR 0.985, <jats:italic>p<\/jats:italic> value\u2009&lt;\u20090.05) and elevated levels of N-terminal pro b-type natriuretic peptide (NT-proBNP) (OR 1.168, <jats:italic>p<\/jats:italic> value\u2009&lt;\u20090.05) were risk factors for CI-AKI. These results were consistent in subgroup analysis. Patients with HFrEF were more likely to develop CI-AKI than those with HFmrEF or HFpEF (OR 0.852, <jats:italic>p<\/jats:italic> value\u2009=\u20090.031). Additionally, lower levels of EF were risk factors for CI-AKI in the HFrEF and HFmrEF groups, but not in the HFpEF group. NT-proBNP was an independent risk factor for CI-AKI in the HFrEF, HFmrEF and HFpEF groups. Elevated levels of NT-proBNP are independent risk factors for CI-AKI irrespective of the classification of HF. Lower levels of EF were risk factors for CI-AKI in the HFrEF and HFmrEF groups, but not in the HFpEF group.<\/jats:p>","DOI":"10.1038\/s41598-021-94910-1","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T10:02:58Z","timestamp":1627466578000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Association of the classification and severity\u00a0of heart failure with the incidence\u00a0of contrast-induced acute kidney injury"],"prefix":"10.1038","volume":"11","author":[{"given":"Tian","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maoning","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liding","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duanbin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Luan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"issue":"5","key":"94910_CR1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3892\/etm.2020.9170","volume":"20","author":"C Wang","year":"2020","unstructured":"Wang, C., Chen, W., Yu, M. & Yang, P. 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