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Forty-six BC patients were enrolled in this study. Blood biochemistry tests were performed to extract RCIs, including prothrombin time (PT), activated partial thromboplastin time (APTT), and thrombin time (TT). Five-minute electrocardiograms were collected for analysis of HRV parameters (SDNN, RMSSD, LF, HF, LF n.u., HF n.u., LF\/HF). Multiple linear regression models examined the relationship of HRV parameters with RCIs. RMSSD, LF n.u., HF n.u., LF\/HF were significantly associated with PT. Specifically, the value of PT increased by 0.192\u2009\u00b1\u20090.091 or 0.231\u2009\u00b1\u20090.088\u00a0s, respectively for each 1 standard deviation (SD) increase in RMSSD or HF n.u.; it increased by 0.230\u2009\u00b1\u20090.088 or 0.215\u2009\u00b1\u20090.088\u00a0s, respectively for each 1 \u2212 SD decrease in LF n.u. or ln (LF\/HF) (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). RMSSD was significantly associated with APTT, i.e., the value of APTT increased by 1.032\u2009\u00b1\u20090.470\u00a0s for each 1 \u2212 SD increase in RMSSD (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). HRV parameters were associated with RCIs in patients with BC. These observations suggest that the autonomic nervous system and coagulation indices in BC patients are linked, potentially explaining the reason that they are both associated with the prognosis.<\/jats:p>","DOI":"10.1038\/s41598-021-94931-w","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T10:03:26Z","timestamp":1627553006000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between short-term heart rate variability and blood coagulation in patients with breast cancer"],"prefix":"10.1038","volume":"11","author":[{"given":"Lingling","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"94931_CR1","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/sj.bjc.6600069","volume":"86","author":"LY Dirix","year":"2002","unstructured":"Dirix, L. 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