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However, the involvement of inflammation in the RRD-induced worsening of retinal circulation was obscure. This retrospective observational study included 150 patients with primary RRD (macula-on, n\u2009=\u200963; macula-off, n\u2009=\u200987) who underwent 25-gauge microincision vitrectomy surgery (25G MIVS). Total retinal blood flow was represented by the mean blur rate (MBR) of the optic nerve head vessel, measured by laser speckle flowgraphy preoperatively and until 6\u00a0months postoperatively. Aqueous humor samples were obtained during surgery to determine cytokine concentrations by enzyme-linked immunosorbent assay. At 3 and 6\u00a0months postoperatively, there were no significant differences between eyes with macula-on RRD and fellow eyes. However, in macula-off RRD, MBR remained significantly lower in RRD eyes 6\u00a0months postoperatively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Log-transformed levels of soluble intercellular adhesion molecule-1 (sICAM-1) were negatively correlated with relative MBR (r-MBR, RRD eye\/fellow eye) before surgery (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.47, <jats:italic>P<\/jats:italic>\u2009=\u20090.01) in macula-on, but not macula-off, RRD. Six months postoperatively, r-MBR correlated significantly with sICAM-1 levels (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.36, <jats:italic>P<\/jats:italic>\u2009=\u20090.02) in macula-off RRD. ICAM-1 may play a role in RRD-induced deterioration of retinal circulation.<\/jats:p>","DOI":"10.1038\/s41598-021-94993-w","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T10:02:43Z","timestamp":1627466563000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Role of ICAM-1 in impaired retinal circulation in rhegmatogenous retinal detachment"],"prefix":"10.1038","volume":"11","author":[{"given":"Harumasa","family":"Yokota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiji","family":"Nagaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Noma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Ofusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoe","family":"Kanemaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Aso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotsugu","family":"Hanazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Yamagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Shimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"94993_CR1","doi-asserted-by":"publisher","first-page":"8745","DOI":"10.1523\/JNEUROSCI.0897-18.2018","volume":"38","author":"H Matsumoto","year":"2018","unstructured":"Matsumoto, H. et al. 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