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Using a double-blinded randomized controlled trial with a 1:1 parallel-group, we investigated the effect of galvanization and the KI iontophoresis in the throat and larynx on three thyroid parameters. A total of\u00a050 healthy volunteers with normal TSH, FT\n                    <jats:sub>3<\/jats:sub>\n                    , and FT\n                    <jats:sub>4<\/jats:sub>\n                    levels and lacking focal changes in the thyroid ultrasonography were subjected to 10 electrotherapy treatments. The TSH, FT\n                    <jats:sub>3<\/jats:sub>\n                    , and FT\n                    <jats:sub>4<\/jats:sub>\n                    levels were determined prior to the 10 electrotherapeutic treatments (T1), 2-weeks after treatment (T2) and 6-months after treatment (T3). At T2 and T3, both groups had normal levels of TSH, FT\n                    <jats:sub>3<\/jats:sub>\n                    , and FT\n                    <jats:sub>4<\/jats:sub>\n                    . Regarding the change of TSH, FT\n                    <jats:sub>3<\/jats:sub>\n                    , and FT\n                    <jats:sub>4<\/jats:sub>\n                    levels between T1 vs. T2 and T1 vs. T3, no significant differences between the galvanization and iontophoresis groups were found.\u00a0However, both groups had lower levels of all three hormones at T3. Together, these data indicate that KI iontophoresis does not affect thyroid hormone levels in the short- nor long-term. Additional follow-up studies with larger groups are required to better confirm the safety of galvanization and iontophoresis procedures in the pharynx and larynx.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial registration<\/jats:bold>\n                    ClinicalTrials.gov (NCT04013308; URL:\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link>\n                    ). Day of first registration 09\/07\/2019.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-95145-w","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T13:37:25Z","timestamp":1628602645000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The effect of galvanization and potassium iodide iontophoresis of the throat and larynx on thyroid parameters: a randomized controlled trial"],"prefix":"10.1038","volume":"11","clinical-trial-number":[{"clinical-trial-number":"nct04013308","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Jolanta","family":"Zwoli\u0144ska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Augustyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Baj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadwiga","family":"Krukowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"issue":"4","key":"95145_CR1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1089\/thy.2000.10.321","volume":"10","author":"C Spitzweg","year":"2000","unstructured":"Spitzweg, C., Heufelder, A. 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