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In this study, we demonstrated a functional diffusible signal factor interspecies quorum sensing signaling mechanism in\n                    <jats:italic>Leptospirillum ferriphilum<\/jats:italic>\n                    and\n                    <jats:italic>Leptospirillum ferrooxidans<\/jats:italic>\n                    that produces (Z)-11-methyl-2-dodecenoic acid when grown with pyrite as energy source. In addition, pure diffusible signal factor and extracts from supernatants of pyrite grown\n                    <jats:italic>Leptospirillum<\/jats:italic>\n                    spp\n                    <jats:italic>.<\/jats:italic>\n                    inhibited biological iron oxidation in various species, and that pyrite grown\n                    <jats:italic>Leptospirillum<\/jats:italic>\n                    cells were less affected than iron grown cells to self inhibition. Finally, transcriptional analyses for the inhibition of iron-grown\n                    <jats:italic>L.\u00a0ferriphilum<\/jats:italic>\n                    cells due to diffusible signal factor was compared with the response to exposure of cells to N- acyl-homoserine-lactone type quorum sensing signal compounds. The data suggested that\n                    <jats:italic>Leptospirillum<\/jats:italic>\n                    spp. diffusible signal factor production is a strategy for niche protection and defense against other microbes and it is proposed that this may be exploited to inhibit unwanted acidophile species.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-95324-9","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T06:09:03Z","timestamp":1628662143000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Diffusible signal factor signaling controls bioleaching activity and niche protection in the acidophilic, mineral-oxidizing leptospirilli"],"prefix":"10.1038","volume":"11","author":[{"given":"S\u00f6ren","family":"Bellenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Salas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Ganji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Jorquera-Rom\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Buetti-Dinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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