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Our current understanding of the underlying brain networks stems primarily from anatomical and functional investigations, but our knowledge of how neurotransmitters subserve numerical skills, the building block of mathematics, is scarce. Using\n                    <jats:sup>1<\/jats:sup>\n                    H magnetic resonance spectroscopy (N\u2009=\u200954, 3T, semi-LASER sequence, TE\u2009=\u200932\u00a0ms, TR\u2009=\u20093.5\u00a0s), the study examined the relation between numerical skills and the brain\u2019s major inhibitory (GABA) and excitatory (glutamate) neurotransmitters. A negative association was found between the performance in a number sequences task and the resting concentration of GABA within the left intraparietal sulcus (IPS), a key region supporting numeracy. The relation between GABA in the IPS and number sequences was specific to (1)\u00a0parietal but not frontal regions and to (2)\u00a0GABA but not glutamate. It was additionally found that the resting functional connectivity of\u00a0the left IPS and\u00a0the left superior frontal gyrus was positively associated with number sequences performance. However, resting GABA concentration within the IPS explained number sequences performance above and beyond the resting frontoparietal connectivity measure. Our findings further motivate the study of inhibition mechanisms in the human brain and significantly contribute to our current understanding of numerical cognition's biological bases.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-95370-3","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T08:22:07Z","timestamp":1630657327000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The relation between parietal GABA concentration and numerical skills"],"prefix":"10.1038","volume":"11","author":[{"given":"George","family":"Zacharopoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Sella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzay","family":"Emir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roi","family":"Cohen Kadosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,3]]},"reference":[{"key":"95370_CR1","doi-asserted-by":"crossref","unstructured":"Cohen Kadosh, R. & Dowker, A. 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