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The present study investigated the relationship between meteorological factors and air pollutants on Meniere\u2019s disease. Participants, aged\u2009\u2265\u200940\u00a0years, of the Korean National Health Insurance Service-Health Screening Cohort were included in this study. The 7725 patients with Meniere\u2019s disease were matched with 30,900 control participants. The moving average meteorological and air pollution data of the previous 7\u00a0days, 1\u00a0month, 3\u00a0months, and 6\u00a0months before the onset of Meniere\u2019s disease were compared between the Meniere\u2019s disease and control groups using conditional logistic regression analyses. Additional analyses were conducted according to age, sex, income, and residential area. Temperature range; ambient atmospheric pressure; sunshine duration; and levels of SO<jats:sub>2<\/jats:sub>, NO<jats:sub>2<\/jats:sub>, O<jats:sub>3<\/jats:sub>, CO, and PM<jats:sub>10<\/jats:sub> for 1\u00a0month and 6\u00a0months were associated with Meniere\u2019s disease. Adjusted ORs (odds ratios with 95% confidence interval [CI]) for 1 and 6\u00a0months of O<jats:sub>3<\/jats:sub> concentration were 1.29 (95% CI 1.23\u20131.35) and 1.31 (95% CI 1.22\u20131.42), respectively; that for the 1 and 6\u00a0months of CO concentration were 3.34 (95% CI 2.39\u20134.68) and 4.19 (95% CI 2.79\u20136.30), respectively. Subgroup analyses indicated a steady relationship of O<jats:sub>3<\/jats:sub> and CO concentrations with Meniere\u2019s disease. Meteorological factors and air pollutants were associated with the rate of Meniere\u2019s disease. 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