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Pituitary surgery often impairs AVP release and results in central diabetes insipidus (CDI). Here, we aimed to investigate how serum copeptin level changes 3\u00a0months after pituitary surgery and whether it has a diagnostic value for postoperative permanent CDI. Consecutive patients who underwent endoscopic transsphenoidal surgery at a single tertiary hospital were recruited. Serum copeptin levels were measured preoperatively and 3\u00a0months postoperatively. Among 88 patients, transient and permanent CDI occurred in 17 (19.3%) and 23 (26.1%), respectively. Three-month postoperative copeptin levels significantly declined from preoperative levels in permanent CDI group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, percentage difference\u2009=\u2009\u2009\u2212\u200942.2%) and also in the transient CDI group (<jats:italic>P<\/jats:italic>\u2009=\u20090.002,\u2009\u2212\u200927.2%). Three months postoperative copeptin level\u2009&lt;\u20091.9\u00a0pmol\/L under normal serum sodium levels was the optimal cutoff value for diagnosing permanent CDI with an accuracy of 81.8%, while 3-month postoperative copeptin level\u2009\u2265\u20093.5\u00a0pmol\/L excluded the CDI with a negative predictive value of 100%. Conclusively, 3\u00a0months postoperative copeptin levels significantly decreased from preoperative levels in the transient CDI group as well as the permanent CDI group. Three-month postoperative copeptin levels\u2009\u2265\u20093.5\u00a0pmol\/L under normal serum sodium levels may be diagnostic for excluding postoperative CDI.<\/jats:p>","DOI":"10.1038\/s41598-021-95500-x","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T10:05:29Z","timestamp":1629972329000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Changes in copeptin levels before and 3\u00a0months after transsphenoidal surgery according to the presence of postoperative central diabetes insipidus"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5923-4915","authenticated-orcid":false,"given":"Yoo Hyung","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9009-4191","authenticated-orcid":false,"given":"Yong Hwy","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Soo","family":"Je","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Ryul","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan Sub","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1932-0234","authenticated-orcid":false,"given":"Jung Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"95500_CR1","doi-asserted-by":"publisher","first-page":"8191","DOI":"10.1021\/bi0400094","volume":"43","author":"C Barat","year":"2004","unstructured":"Barat, C., Simpson, L. & Breslow, E. Properties of human vasopressin precursor constructs: Inefficient monomer folding in the absence of copeptin as a potential contributor to diabetes insipidus. Biochemistry 43, 8191\u20138203. https:\/\/doi.org\/10.1021\/bi0400094 (2004).","journal-title":"Biochemistry"},{"key":"95500_CR2","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1373\/clinchem.2005.060038","volume":"52","author":"NG Morgenthaler","year":"2006","unstructured":"Morgenthaler, N. G., Struck, J., Alonso, C. & Bergmann, A. Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin. Chem. 52, 112\u2013119. https:\/\/doi.org\/10.1373\/clinchem.2005.060038 (2006).","journal-title":"Clin. Chem."},{"key":"95500_CR3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.tem.2007.11.001","volume":"19","author":"NG Morgenthaler","year":"2008","unstructured":"Morgenthaler, N. G., Struck, J., Jochberger, S. & D\u00fcnser, M. W. 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