{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:49:23Z","timestamp":1785332963707,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005713","name":"Technische Universit\u00e4t M\u00fcnchen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005713","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>TroponinT levels are frequently elevated after subarachnoid hemorrhage (SAH). However, their clinical impact on long term outcomes still remains unclear. This study evaluates the association of TroponinT and functional outcomes 3\u00a0months after SAH.  Data were obtained in the frame of a randomized controlled trial exploring the association of Goal-directed hemodynamic therapy and outcomes after SAH (NCT01832389). TroponinT was measured daily for the first 14\u00a0days after admission or until discharge from the ICU. Outcome was assessed using Glasgow Outcome Scale (GOS) 3\u00a0months after discharge. Logistic regression was used to explore the association between initial TroponinT values stratified by tertiles and admission as well as outcome parameters. TroponinT measurements were analyzed in 105 patients. TroponinT values at admission were associated with outcome assessed by GOS in a univariate analysis. TroponinT was not predictive of vasospasm or delayed cerebral ischemia, but an association with pulmonary and cardiac complications was observed. After adjustment for age, history of arterial hypertension and World Federation of Neurosurgical Societies (WFNS) grade, TroponinT levels at admission were not independently associated with worse outcome (GOS 1\u20133) or death at 3\u00a0months. In summary,\u00a0TroponinT levels at admission are associated with 3\u00a0months-GOS but have limited ability to independently predict outcome after SAH.<\/jats:p>","DOI":"10.1038\/s41598-021-95717-w","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T10:10:36Z","timestamp":1628503836000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of Troponin T levels and functional outcome 3\u00a0months after subarachnoid hemorrhage"],"prefix":"10.1038","volume":"11","author":[{"given":"Aida","family":"Anetsberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Jungwirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Blobner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Ringel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabell","family":"Bernlochner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Heim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Bogdanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Wostrack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Grae\u00dfner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Baumgart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Gempt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"key":"95717_CR1","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1097\/01.CCM.0000201903.46435.35","volume":"3","author":"KE Wartenberg","year":"2006","unstructured":"Wartenberg, K. E. et al. Impact of medical complications on outcome after subarachnoid hemorrhage. Crit. Care Med. 3, 617\u2013623 (2006).","journal-title":"Crit. Care Med."},{"key":"95717_CR2","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/S0140-6736(07)60153-6","volume":"369","author":"J Van Gijn","year":"2007","unstructured":"Van Gijn, J., Kerr, R. S. & Rinkel, G. J. Subarachnoid haemorrhage. Lancet 369, 306\u2013318 (2007).","journal-title":"Lancet"},{"key":"95717_CR3","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1161\/CIRCULATIONAHA.105.533620","volume":"112","author":"AM Naidech","year":"2005","unstructured":"Naidech, A. M. et al. Cardiac troponin elevation, cardiovascular morbidity, and outcome after subarachnoid hemorrhage. Circulation 112, 2851\u20132856 (2005).","journal-title":"Circulation"},{"key":"95717_CR4","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.clineuro.2012.09.006","volume":"115","author":"KJ Kilbourn","year":"2013","unstructured":"Kilbourn, K. J., Levy, S., Staff, I., Kureshi, I. & McCullough, L. Clinical characteristics and outcomes of neurogenic stress cadiomyopathy in aneurysmal subarachnoid hemorrhage. Clin. Neurol. Neurosurg. 115, 909\u2013914 (2013).","journal-title":"Clin. Neurol. Neurosurg."},{"key":"95717_CR5","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1007\/s12028-018-0558-0","volume":"29","author":"E Norberg","year":"2018","unstructured":"Norberg, E., Odenstedt-Herges, H., Rydenhag, B. & Oras, J. Impact of acute cardiac complications after subarachnoid hemorrhage on long-term mortality and cardiovascular events. Neurocrit. Care. 29, 404\u2013412 (2018).","journal-title":"Neurocrit. Care."},{"key":"95717_CR6","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1007\/s12028-019-00734-3","volume":"32","author":"M Megjhani","year":"2020","unstructured":"Megjhani, M. et al. Heart rate variability as a biomarker of neurocardiogenic injury after subarachnoid hemorrhage. Neurocrit. Care. 32, 162\u2013171 (2020).","journal-title":"Neurocrit. Care."},{"key":"95717_CR7","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1212\/WNL.0000000000000057","volume":"82","author":"I van der Bilt","year":"2014","unstructured":"van der Bilt, I. et al. Cardiac dysfunction after aneurysmal subarachnoid hemorrhage: relationship with outcome. Neurology 82, 351\u2013358 (2014).","journal-title":"Neurology"},{"key":"95717_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13054-015-1181-5","volume":"20","author":"J Oras","year":"2016","unstructured":"Oras, J. et al. Elevated high-sensitive troponin T on admission is an indicator of poor long-term outcome in patients with subarachnoid haemorrhage: a prospective observational study. Crit. Care 20, 11 (2016).","journal-title":"Crit. Care"},{"key":"95717_CR9","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1161\/STROKEAHA.120.029279","volume":"51","author":"A Anetsberger","year":"2020","unstructured":"Anetsberger, A. et al. Impact of goal-directed therapy on delayed ischemia after aneurysmal subarachnoid hemorrhage: randomized controlled trial. Stroke 51, 2287\u20132296 (2020).","journal-title":"Stroke"},{"key":"95717_CR10","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1161\/STR.0b013e3182587839","volume":"43","author":"ES Connolly","year":"2012","unstructured":"Connolly, E. S. et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage. Stroke 43, 1711\u20131737 (2012).","journal-title":"Stroke"},{"key":"95717_CR11","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/S0140-6736(75)92830-5","volume":"1","author":"B Jennett","year":"1975","unstructured":"Jennett, B. & Bond, M. Assessment of outcome after severe brain damage. Lancet 1, 480\u2013484 (1975).","journal-title":"Lancet"},{"key":"95717_CR12","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3171\/jns.1968.28.1.0014","volume":"28","author":"WE Hunt","year":"1968","unstructured":"Hunt, W. E. & Hess, R. M. Surgical risk as related to time of intervention in the repair of intracranial aneurysms. J. Neurosurg. 28, 14\u201320 (1968).","journal-title":"J. Neurosurg."},{"key":"95717_CR13","first-page":"985","volume":"68","author":"C Drake","year":"1988","unstructured":"Drake, C. Report of world federation of neurological surgeons committee on a universal subarachnoid hemorrhage grading scale. J. Neurosurg. 68, 985\u2013986 (1988).","journal-title":"J. Neurosurg."},{"key":"95717_CR14","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1227\/01.NEU.0000218821.34014.1B","volume":"59","author":"JA Frontera","year":"2006","unstructured":"Frontera, J. A. et al. Prediction of symptomatic vasospasm after subarachnoid hemorrhage: the modified fisher scale. Neurosurgery 59, 21\u201327 (2006).","journal-title":"Neurosurgery"},{"key":"95717_CR15","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1161\/CIR.0b013e31826e1058","volume":"126","author":"K Thygesen","year":"2012","unstructured":"Thygesen, K. et al. Third universal definition of myocardial infarction. Circulation 126, 2020\u20132533 (2012).","journal-title":"Circulation"},{"key":"95717_CR16","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1161\/01.STR.23.5.674","volume":"23","author":"DG Grosset","year":"1992","unstructured":"Grosset, D. G., Straiton, J., du Trevou, M. & Bullock, R. Prediction of symptomatic vasospasm after subarachnoid hemorrhage by rapidly increasing transcranial Doppler velocity and cerebral blood flow changes. Stroke 23, 674\u2013679 (1992).","journal-title":"Stroke"},{"key":"95717_CR17","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1161\/STROKEAHA.107.484360","volume":"38","author":"AJ Rosengart","year":"2007","unstructured":"Rosengart, A. J., Schultheiss, K. E., Tolentino, J. & Macdonald, R. L. Prognostic factors for outcome in patients with aneurysmal subarachnoid hemorrhage. Stroke 38, 2315\u20132321 (2007).","journal-title":"Stroke"},{"key":"95717_CR18","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1161\/STROKEAHA.110.589275","volume":"41","author":"MD Vergouwen","year":"2010","unstructured":"Vergouwen, M. D. et al. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke 41, 2391\u20132395 (2010).","journal-title":"Stroke"},{"key":"95717_CR19","doi-asserted-by":"publisher","first-page":"j5745","DOI":"10.1136\/bmj.j5745","volume":"360","author":"BNR Jaja","year":"2018","unstructured":"Jaja, B. N. R. et al. Development and validation of outcome prediction models for aneurysmal subarachnoid haemorrhage: the SAHIT multinational cohort study. BMJ 360, j5745 (2018).","journal-title":"BMJ"},{"key":"95717_CR20","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s12028-011-9598-4","volume":"15","author":"N Bruder","year":"2011","unstructured":"Bruder, N., Rabinstein, A. & Participants in the International Multi-Disciplinary Consensus Conference on the Critical Care Management of Subarachnoid Hemorrhage. Cardiovascular and pulmonary complications of aneurysmal subarachnoid hemorrhage. Neurocrit. Care 15, 257\u2013269 (2011).","journal-title":"Neurocrit. Care"},{"key":"95717_CR21","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1007\/s12028-011-9592-x","volume":"17","author":"JG Zaroff","year":"2012","unstructured":"Zaroff, J. G. et al. Cardiovascular predictors of long-term outcomes after non-traumatic subarachnoid hemorrhage. Neurocrit. Care 17, 374\u2013381 (2012).","journal-title":"Neurocrit. Care"},{"key":"95717_CR22","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1385\/NCC:5:2:102","volume":"5","author":"S Yarlagadda","year":"2006","unstructured":"Yarlagadda, S. et al. Cardiovascular predictors of in-patient mortality after subarachnoid hemorrhage. Neurocrit. Care 5, 102\u2013107 (2006).","journal-title":"Neurocrit. Care"},{"key":"95717_CR23","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1212\/01.wnl.0000342471.07290.07","volume":"72","author":"IA van der Bilt","year":"2009","unstructured":"van der Bilt, I. A. et al. Impact of cardiac complications on outcome after aneurysmal subarachnoid hemorrhage: a meta-analysis. Neurology 72, 635\u2013642 (2009).","journal-title":"Neurology"},{"key":"95717_CR24","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.1161\/CIRCULATIONAHA.105.558239","volume":"112","author":"NM Banki","year":"2005","unstructured":"Banki, N. M. et al. Acute neurocardiogenic injury after subarachnoid hemorrhage. Circulation 112, 3314\u20133319 (2005).","journal-title":"Circulation"},{"key":"95717_CR25","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1080\/02699052.2019.1641742","volume":"33","author":"P Guette","year":"2019","unstructured":"Guette, P. et al. Prognostic value of high-sensitivity troponin T in aneurysmal subarachnoid hemorrhage: a prospective observational study. Brain Inj. 33, 1372\u20131378 (2019).","journal-title":"Brain Inj."},{"key":"95717_CR26","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s12028-014-0105-6","volume":"23","author":"KM Duello","year":"2015","unstructured":"Duello, K. M., Nagel, J. P., Thomas, C. S., Blackshear, J. L. & Freeman, W. D. Relationship of troponin T and age- and sex-adjusted BNP elevation following subarachnoid hemorrhage with 30-day mortality. Neurocrit. Care 23, 59\u201365 (2015).","journal-title":"Neurocrit. Care"},{"key":"95717_CR27","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/S0735-1097(00)00857-3","volume":"36","author":"N Parekh","year":"2000","unstructured":"Parekh, N. et al. Cardiac troponin I predicts myocardial dysfunction in aneurysmal subarachnoid hemorrhage. J. Am. Coll. Cardiol. 36, 1328\u20131335 (2000).","journal-title":"J. Am. Coll. Cardiol."},{"key":"95717_CR28","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s12028-009-9223-y","volume":"11","author":"AM Naidech","year":"2009","unstructured":"Naidech, A. M. et al. Cardiac troponin I and acute lung injury after subarachnoid hemorrhage. Neurocrit. Care 11, 177\u2013182 (2009).","journal-title":"Neurocrit. Care"},{"key":"95717_CR29","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1093\/eurheartj\/ehv320","volume":"37","author":"M Roffi","year":"2016","unstructured":"Roffi, M. et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur. Heart J. 37, 267\u2013315 (2016).","journal-title":"Eur. Heart J."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-95717-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-95717-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-95717-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T12:28:17Z","timestamp":1670070497000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-95717-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,9]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["95717"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-95717-w","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,9]]},"assertion":[{"value":"7 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"JG: Consulting: BrainLab, Funded Research: Zeiss; MB: grants and personal fees from MSD, personal fees from Gr\u00fcnenthal, and personal fees from GE Healthcare outside the submitted work; BM: Honoraria: Brainlab, Relievant, DepuySynthes, Icotec, Medtronic, Spineart, Ulrich Medical; Consulting\/Advisory Board: Relievant, DepuySynthes, Icotec, Medtronic, Spineart; Funded research: Brainlab, Relievant, Icotec, Medtronic, Ulrich Medical, Royalties\/Patent: Spineart; all other authors declared no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16154"}}