{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:07:28Z","timestamp":1793704048041,"version":"4.5.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Defense Science and Engineering Graduate Fellowship"},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH2010855"],"award-info":[{"award-number":["W81XWH2010855"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"WayVector Sponsored Research Agreement"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sensorineural hearing loss (SNHL) is one of the most profound public health concerns of the modern era, affecting 466 million people today, and projected to affect 900 million by the year 2050. Advances in both diagnostics and therapeutics for SNHL have been impeded by the human cochlea\u2019s inaccessibility for in vivo imaging, resulting from its extremely small size, convoluted coiled configuration, fragility, and deep encasement in dense bone. Here, we develop and demonstrate the ability of a sub-millimeter-diameter, flexible endoscopic probe interfaced with a micro-optical coherence tomography (\u03bcOCT) imaging system to enable micron-scale imaging of the inner ear\u2019s sensory epithelium in cadaveric human inner ears.<\/jats:p>","DOI":"10.1038\/s41598-021-95991-8","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T10:06:24Z","timestamp":1631181984000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter"],"prefix":"10.1038","volume":"11","author":[{"given":"Janani S.","family":"Iyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biwei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina M.","family":"Stankovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo J.","family":"Tearney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"95991_CR1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.heares.2019.03.003","volume":"377","author":"SG Kujawa","year":"2019","unstructured":"Kujawa, S. G. & Liberman, M. C. Translating animal models to human therapeutics in noise-induced and age-related hearing loss. Hear. Res. 377, 44\u201352. https:\/\/doi.org\/10.1016\/j.heares.2019.03.003 (2019).","journal-title":"Hear. Res."},{"key":"95991_CR2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a033548","author":"CJ Kros","year":"2019","unstructured":"Kros, C. J. & Steyger, P. S. Aminoglycoside- and cisplatin-induced ototoxicity: Mechanisms and otoprotective strategies. Cold Spring Harb. Perspect. Med. https:\/\/doi.org\/10.1101\/cshperspect.a033548 (2019).","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"95991_CR3","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1097\/MAO.0b013e318184f492","volume":"29","author":"CC Finley","year":"2008","unstructured":"Finley, C. C. et al. Role of electrode placement as a contributor to variability in cochlear implant outcomes. Otol. 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His financial\/fiduciary interest was reviewed and is managed by the Massachusetts General Hospital and Partners HealthCare in accordance with their conflict of interest policies. KMS, GJT, and JSI and are inventors on \u00b5OCT patents related to this work (US patent 20190029570). BY has no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17932"}}