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Data from 105 RA patients and 102 age- and gender-matched healthy controls were collected in the retrospective study. Disease activity score in 28 joints based on C-reactive protein (DAS28-CRP) was used to divide RA patients into low activity group (DAS28-CRP\u2009\u2264\u20092.7) and active group (DAS28-CRP\u2009&gt;\u20092.7). Receiver operating characteristic (ROC) curve was applied to determine area under the curve (AUC). The association between plasma FIB, <jats:sc>d<\/jats:sc>-dimer, and FDP and DAS28-CRP was evaluated by spearman correlation. Logistical regression analysis was used to identify the independent variables associated with RA disease activity. RA patients showed higher levels of plasma FIB, <jats:sc>d<\/jats:sc>-dimer, and FDP than the controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Plasma FIB, <jats:sc>d<\/jats:sc>-dimer, and FDP were also increased in active groups of RA patients than those in inactive groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). ROC curve analyses revealed that the AUC of <jats:sc>d<\/jats:sc>-dimer was higher than erythrocyte sedimentation rate (ESR) and rheumatoid factor (RF), and that of FDP was higher than RF in RA patients. In addition, the optimal cut-off value of plasma FIB, <jats:sc>d<\/jats:sc>-dimer, and FDP for RA diagnosis was 286\u00a0mg\/dL, 470\u00a0\u03bcg\/L, and 1.45\u00a0mg\/L, respectively. Spearman analysis showed that plasma FIB, <jats:sc>d<\/jats:sc>-dimer, and FDP were positively related with DAS28-CRP (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) in RA patients. Logistical regression analysis showed that <jats:sc>d<\/jats:sc>-dimer (odds ratio 2.862, 95% confidence interval 1.851\u20135.426, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) was an independent variable associated with RA disease activity. FIB, <jats:sc>d<\/jats:sc>-dimer, and FDP were increased in RA patients and positively correlated with the disease activity of RA. <jats:sc>d<\/jats:sc>-dimer may act as a novel inflammatory indice for indicating disease activity in RA patients.<\/jats:p>","DOI":"10.1038\/s41598-021-96349-w","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T10:30:05Z","timestamp":1629369005000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Plasma fibrinogen, d-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis"],"prefix":"10.1038","volume":"11","author":[{"given":"Li","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanying","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoliang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeshi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"key":"96349_CR1","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1056\/NEJMra1004965","volume":"365","author":"IB McInnes","year":"2011","unstructured":"McInnes, I. 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