{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:50:36Z","timestamp":1787730636775,"version":"build-2784847793"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K07CA160718"],"award-info":[{"award-number":["K07CA160718"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>MOTS-c is a mitochondrial derived peptide with exercise mimetic activity that elicits beneficial effects on metabolism and exercise capacity. Furthermore, MOTS-c effects in humans are affected by race, potentially via ethnic-specific mtDNA variations. Women treated for breast cancer are at an increased risk for cardiovascular disease, diabetes and obesity, due to side effects of cancer-treatments. We conducted a secondary analysis of the effects of a 16-week aerobic and resistance exercise intervention on MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors (BCS). BCS (Stage I\u2013III) were randomized to exercise or standard care. The intervention promoted aerobic and resistance exercise for 16\u00a0weeks. MOTS-c was analyzed in fasting plasma using an in-house ELISA. Within and between group differences were assessed by paired t-test and repeated measures ANOVA. Pearson\u2019s correlation was computed to assess the association between MOTS-c and metabolic biomarkers at baseline and post-exercise. Twenty-five Hispanic-BCS and 24 non-Hispanic White BCS were included. Hispanic BCS were younger, of greater adiposity, had higher stage cancers, and had worse metabolic profiles at baseline compared to non-Hispanic White BCS (p\u2009&lt;\u20090.001). Post-exercise, MOTS-c levels significantly increased when compared to baseline and the usual care group among non-Hispanic White BCS (p\u2009&lt;\u20090.01) but not among Hispanic breast cancer survivors (p\u2009&gt;\u20090.01). Post-exercise levels of MOTS-c among non-Hispanic White BCS were significantly associated with reductions in fat mass, body weight, HOMA-IR, CRP, and an increase in lean mass (p\u2009&lt;\u20090.01). A 16-week aerobic and resistance intervention increased MOTS-c levels among non-Hispanic White BCS.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial registration:<\/jats:bold>\n                    This trial is registered on ClinicalTrials.gov: NCT01140282 as of June 9, 2010.\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01140282\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01140282<\/jats:ext-link>\n                    .\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-96419-z","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T06:30:05Z","timestamp":1629354605000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors"],"prefix":"10.1038","volume":"11","clinical-trial-number":[{"clinical-trial-number":"nct01140282","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Christina M.","family":"Dieli-Conwright","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Sami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K.","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxiang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kumagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Jeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinchas","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"key":"96419_CR1","doi-asserted-by":"publisher","first-page":"109075","DOI":"10.1016\/j.biopha.2019.109075","volume":"117","author":"Y Yang","year":"2019","unstructured":"Yang, Y. et al. The role of mitochondria-derived peptides in cardiovascular disease: recent updates. Biomed. Pharmacother. 117, 109075 (2019).","journal-title":"Biomed. Pharmacother."},{"key":"96419_CR2","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.freeradbiomed.2016.05.015","volume":"100","author":"C Lee","year":"2016","unstructured":"Lee, C., Kim, K. H. & Cohen, P. MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic. Biol. Med. 100, 182\u2013187 (2016).","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"96419_CR3","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.cmet.2015.02.009","volume":"21","author":"C Lee","year":"2015","unstructured":"Lee, C. et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 21(3), 443\u2013454 (2015).","journal-title":"Cell Metab."},{"key":"96419_CR4","first-page":"1692","volume":"13","author":"H Zempo","year":"2021","unstructured":"Zempo, H. et al. A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c. BioRxiv 13, 1692 (2021).","journal-title":"BioRxiv"},{"issue":"9","key":"96419_CR5","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1097\/GME.0000000000001348","volume":"26","author":"D de Araujo Brito Buttros","year":"2019","unstructured":"de Araujo Brito Buttros, D. et al. High risk for cardiovascular disease in postmenopausal breast cancer survivors. Menopause 26(9), 1024\u20131030 (2019).","journal-title":"Menopause"},{"issue":"6","key":"96419_CR6","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1249\/JSR.0b013e3181c22324","volume":"8","author":"KM Mustian","year":"2009","unstructured":"Mustian, K. M. et al. Exercise for the management of side effects and quality of life among cancer survivors. Curr. Sports Med. Rep. 8(6), 325 (2009).","journal-title":"Curr. Sports Med. Rep."},{"issue":"2","key":"96419_CR7","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1097\/00005082-200603000-00012","volume":"21","author":"C Keller","year":"2006","unstructured":"Keller, C. & Fleury, J. Factors related to physical activity in Hispanic women. J. Cardiovasc. Nurs. 21(2), 142\u2013145 (2006).","journal-title":"J. Cardiovasc. Nurs."},{"issue":"9","key":"96419_CR8","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1200\/JCO.2017.75.7526","volume":"36","author":"CM Dieli-Conwright","year":"2018","unstructured":"Dieli-Conwright, C. M. et al. Effects of aerobic and resistance exercise on metabolic syndrome, sarcopenic obesity, and circulating biomarkers in overweight or obese survivors of breast cancer: A randomized controlled trial. J. Clin. 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