{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T21:55:17Z","timestamp":1776462917105,"version":"3.51.2"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ultrasound-guided axillary brachial plexus block is increasingly used in preschool-age patients. However, the minimum effective volume of local anaesthetics has not been determined. With ethical committee approval and written informed consent from the guardians of all paediatric patients, we studied 27 consecutive patients aged 3 to 6\u00a0years who were scheduled for hand surgery. After general anaesthesia, eligible patients received a set volume of ultrasound-guided axillary brachial plexus block. We determined the volume of 0.2% ropivacaine for consecutive patients from the preceding patient\u2019s outcome. The initial volume was 0.4\u00a0ml\/kg. The testing interval was set at 0.05\u00a0ml\/kg, and the lowest volume was 0.1\u00a0ml\/kg. The following conditions were defined as a successful block: no heart rate changes, body movement, or ventilatory disorders during the operation; no use of fentanyl in the PACU; and a postoperative sensory block score\u2009&lt;\u20093. The sequences of positive and negative blocks in consecutive patients were recorded. Using probit regression analysis, the 50% effective volume was 0.185\u00a0ml\/kg (95% CI 0.123\u20130.234), and the 95% effective volume was 0.280\u00a0ml\/kg (95% CI 0.232\u20130.593). EV50 and EV95 values of 0.2% ropivacaine for ultrasound-guided axillary brachial plexus block were 0.185\u00a0ml\/kg and 0.280\u00a0ml\/kg, respectively.<\/jats:p>","DOI":"10.1038\/s41598-021-96582-3","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T10:02:51Z","timestamp":1629453771000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Minimum effective volume of 0.2% ropivacaine for ultrasound-guided axillary brachial plexus block in preschool-age children"],"prefix":"10.1038","volume":"11","author":[{"given":"Liang","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangmei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"96582_CR1","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/AAP.0b013e3181fa1190","volume":"35","author":"SH Renes","year":"2010","unstructured":"Renes, S. H., van Geffen, G. J., Rettig, H. C., Gielen, M. J. & Scheffer, G. J. Minimum effective volume of local anesthetic for shoulder analgesia by ultrasound-guided block at root C7 with assessment of pulmonary function. Reg. Anesth. Pain Med. 35, 529\u2013534 (2010).","journal-title":"Reg. Anesth. Pain Med."},{"key":"96582_CR2","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1213\/ANE.0b013e3181eb6372","volume":"111","author":"M Ponrouch","year":"2010","unstructured":"Ponrouch, M. et al. Estimation and pharmacodynamic consequences of the minimum effective anesthetic volume for median and ulnar nerve blocks: a randomized, double-blind, controlled comparison between ultrasound and nerve stimulation guidance. Anesth. Analg. 111, 1059\u20131064 (2010).","journal-title":"Anesth. Analg."},{"key":"96582_CR3","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1097\/AAP.0b013e3181d22fe0","volume":"35","author":"MN Joseph","year":"2010","unstructured":"Joseph, M. N. et al. 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