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In this secondary data analysis from a prospective study evaluating epidural regimens, we investigated the potential associations between depressive symptomatology, anxiety, and pain catastrophizing with perceived stress during labor. Healthy nulliparous adult women with term singleton pregnancies requesting for epidural analgesia in early labor were included. Assessments were administered after epidural analgesia and adequate pain relief were achieved. Perceived stress (Perceived Stress Scale, PSS, high PSS\u2009\u2265\u200916), depressive symptomatology (Edinburgh Postnatal Depression Scale, EPDS, high EPDS\u2009\u2265\u200910), and pain catastrophizing (Pain Catastrophizing Scale, PCS, high total PCS\u2009\u2265\u200925) were assessed as categorical variables. Additionally, anxiety (State-trait Anxiety Inventory, STAI), PCS total and its subscales (rumination, magnification and helplessness) were analyzed as continuous variables. Univariate and multivariable logistic regression models were used to identify factors associated with high PSS. Of 801 women included, 411 (51.9%) had high PSS. High EPDS (OR 2.16, 95%CI 1.36\u20133.44), increasing trait anxiety (OR 1.17, 95%CI 1.14\u20131.20), and increasing pain magnification (OR 1.12, 95%CI 1.05\u20131.19) were independently associated with high PSS. Depressive symptomatology, trait anxiety, and pain magnification were associated with perceived stress during labor, providing impetus for future research aimed at detecting and alleviating stress and its psychological or pain association factors.<\/jats:p>","DOI":"10.1038\/s41598-021-96620-0","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T10:02:51Z","timestamp":1629453771000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Perceived stress during labor and its association with depressive symptomatology, anxiety, and pain catastrophizing"],"prefix":"10.1038","volume":"11","author":[{"given":"Hon Sen","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Agarthesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin Wen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehena","family":"Sultana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze-Ern","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ban Leong","family":"Sng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"96620_CR1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1207\/S15327558IJBM0801_04","volume":"8","author":"S Alehagen","year":"2001","unstructured":"Alehagen, S., Wijma, K., Lundberg, U., Melin, B. & Wijma, B. 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