{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:44:00Z","timestamp":1793727840218,"version":"4.6.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Region Stockholm","award":["Clinical post-doctoral appointment"],"award-info":[{"award-number":["Clinical post-doctoral appointment"]}]},{"DOI":"10.13039\/100009604","name":"Jochnick Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009604","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Stockholm County Council","award":["ALF 20181157"],"award-info":[{"award-number":["ALF 20181157"]}]},{"DOI":"10.13039\/501100018713","name":"CIMED","doi-asserted-by":"crossref","award":["20180889"],"award-info":[{"award-number":["20180889"]}],"id":[{"id":"10.13039\/501100018713","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish Cancer Society","award":["170690"],"award-info":[{"award-number":["170690"]}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neutrophil extracellular traps (NETs) are web-like structures consisting of DNA, histones and granule proteins, released from neutrophils in thrombus formation, inflammation, and cancer. We asked if plasma levels of the NET markers myeloperoxidase (MPO)-DNA and citrullinated histone H3 (H3Cit)-DNA, are elevated in liver cirrhosis and hepatocellular carcinoma (HCC) and if the levels correlate with clinical parameters. MPO-DNA, H3Cit-DNA, and thrombin\u2013antithrombin (TAT) complex, as a marker of coagulation activity, were measured using ELISA in plasma from 82 patients with HCC, 95 patients with cirrhosis and 50 healthy controls. Correlations were made to clinical parameters and laboratory data and patients were followed for a median of 22.5\u00a0months regarding thrombosis development. H3Cit-DNA was significantly (p\u2009&lt;\u20090.01) elevated in plasma from cirrhosis (66.4\u00a0ng\/mL) and HCC (63.8\u00a0ng\/mL) patients compared to healthy controls (31.8\u00a0ng\/mL). TAT levels showed similar pattern (3.1, 3.7, and 0.0\u00a0\u00b5g\/mL respectively, p\u2009&lt;\u20090.01). MPO-DNA was significantly (p\u2009&lt;\u20090.01) elevated in cirrhosis patients (0.53 O.D.) as compared to controls (0.33 O.D.). Levels of MPO-DNA and H3Cit-DNA correlated positively with Child\u2013Pugh and MELD score. TAT was increased in all Child\u2013Pugh and MELD groups. In multivariable logistic regression, Child B and C liver cirrhosis were independent predictors of elevated H3Cit-DNA in plasma. Levels of MPO-DNA and H3Cit-DNA were similar in patients with or without history of thrombosis, or thrombus formation during follow-up. In conclusion,\u00a0plasma markers of NET formation are elevated in liver cirrhosis and correlate to the degree of liver dysfunction in patients with liver cirrhosis and\/or HCC. The presence of HCC did not further increase the plasma levels of NET markers as compared to patients with cirrhosis only.<\/jats:p>","DOI":"10.1038\/s41598-021-97233-3","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T06:06:24Z","timestamp":1631167584000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Neutrophil extracellular traps in patients with liver cirrhosis and hepatocellular carcinoma"],"prefix":"10.1038","volume":"11","author":[{"given":"Robin","family":"Zenlander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Havervall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennie","family":"Engstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"\u00c5gren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Th\u00e5lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"St\u00e5l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"97233_CR1","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s00441-017-2780-z","volume":"371","author":"G Christoffersson","year":"2018","unstructured":"Christoffersson, G. & Phillipson, M. The neutrophil: One cell on many missions or many cells with different agendas?. Cell Tissue Res. 371, 415\u2013423. https:\/\/doi.org\/10.1007\/s00441-017-2780-z (2018).","journal-title":"Cell Tissue Res."},{"key":"97233_CR2","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","volume":"303","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann, V. et al. Neutrophil extracellular traps kill bacteria. Science (New York, NY) 303, 1532\u20131535. https:\/\/doi.org\/10.1126\/science.1092385 (2004).","journal-title":"Science (New York, NY)"},{"key":"97233_CR3","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1161\/atvbaha.119.312463","volume":"39","author":"C Th\u00e5lin","year":"2019","unstructured":"Th\u00e5lin, C., Hisada, Y., Lundstr\u00f6m, S., Mackman, N. & Wall\u00e9n, H. Neutrophil extracellular traps: Villains and targets in arterial, venous, and cancer-associated thrombosis. Arterioscler. Thromb. Vasc. Biol. 39, 1724\u20131738. https:\/\/doi.org\/10.1161\/atvbaha.119.312463 (2019).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"97233_CR4","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1007\/s12026-017-8905-3","volume":"65","author":"C Th\u00e5lin","year":"2017","unstructured":"Th\u00e5lin, C. et al. Validation of an enzyme-linked immunosorbent assay for the quantification of citrullinated histone H3 as a marker for neutrophil extracellular traps in human plasma. Immunol. Res. 65, 706\u2013712. https:\/\/doi.org\/10.1007\/s12026-017-8905-3 (2017).","journal-title":"Immunol. Res."},{"key":"97233_CR5","doi-asserted-by":"publisher","first-page":"15880","DOI":"10.1073\/pnas.1005743107","volume":"107","author":"TA Fuchs","year":"2010","unstructured":"Fuchs, T. A. et al. Extracellular DNA traps promote thrombosis. Proc. Natl. Acad. Sci. USA 107, 15880\u201315885. https:\/\/doi.org\/10.1073\/pnas.1005743107 (2010).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"97233_CR6","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1002\/hep.29914","volume":"68","author":"DJ van der Windt","year":"2018","unstructured":"van der Windt, D. J. et al. Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis. Hepatology 68, 1347\u20131360. https:\/\/doi.org\/10.1002\/hep.29914 (2018).","journal-title":"Hepatology"},{"key":"97233_CR7","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao4227","author":"J Albrengues","year":"2018","unstructured":"Albrengues, J. et al. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science (New York, NY). https:\/\/doi.org\/10.1126\/science.aao4227 (2018).","journal-title":"Science (New York, NY)."},{"key":"97233_CR8","doi-asserted-by":"publisher","first-page":"e1098803","DOI":"10.1080\/2162402X.2015.1098803","volume":"5","author":"J Cedervall","year":"2016","unstructured":"Cedervall, J., Dimberg, A. & Olsson, A. K. Tumor-induced neutrophil extracellular traps-drivers of systemic inflammation and vascular dysfunction. Oncoimmunology 5, e1098803. https:\/\/doi.org\/10.1080\/2162402X.2015.1098803 (2016).","journal-title":"Oncoimmunology"},{"key":"97233_CR9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13045-019-0836-0","volume":"13","author":"LY Yang","year":"2020","unstructured":"Yang, L. Y. et al. Increased neutrophil extracellular traps promote metastasis potential of hepatocellular carcinoma via provoking tumorous inflammatory response. J. Hematol. Oncol. 13, 3. https:\/\/doi.org\/10.1186\/s13045-019-0836-0 (2020).","journal-title":"J. Hematol. Oncol."},{"key":"97233_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2020.06.012","author":"CT Kaltenmeier","year":"2020","unstructured":"Kaltenmeier, C. T. et al. Neutrophil extracellular traps as a novel biomarker to predict recurrence-free and overall survival in patients with primary hepatic malignancies. HPB (Oxford) https:\/\/doi.org\/10.1016\/j.hpb.2020.06.012 (2020).","journal-title":"HPB (Oxford)"},{"key":"97233_CR11","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1002\/hep.31646","volume":"73","author":"PG Northup","year":"2021","unstructured":"Northup, P. G. et al. Vascular liver disorders, portal vein thrombosis, and procedural bleeding in patients with liver Disease: 2020 Practice Guidance by the American Association for the Study of Liver Diseases. Hepatology (Baltimore, MD) 73, 366\u2013413. https:\/\/doi.org\/10.1002\/hep.31646 (2021).","journal-title":"Hepatology (Baltimore, MD)"},{"key":"97233_CR12","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1002\/hep.31201","volume":"71","author":"MG Zermatten","year":"2020","unstructured":"Zermatten, M. G. et al. Hemostatic alterations in patients with cirrhosis: From primary hemostasis to fibrinolysis. Hepatology (Baltimore, MD) 71, 2135\u20132148. https:\/\/doi.org\/10.1002\/hep.31201 (2020).","journal-title":"Hepatology (Baltimore, MD)"},{"key":"97233_CR13","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/S1665-2681(19)31312-2","volume":"12","author":"J Muci\u00f1o-Bermejo","year":"2013","unstructured":"Muci\u00f1o-Bermejo, J., Carrillo-Esper, R., Uribe, M. & M\u00e9ndez-S\u00e1nchez, N. Coagulation abnormalities in the cirrhotic patient. Ann. Hepatol. 12, 713\u2013724 (2013).","journal-title":"Ann. Hepatol."},{"key":"97233_CR14","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26282","author":"EL Ryon","year":"2020","unstructured":"Ryon, E. L. et al. Surgical management of hepatocellular carcinoma patients with portal vein thrombosis: The United States Safety Net and Academic Center Collaborative Analysis. J. Surg. Oncol. https:\/\/doi.org\/10.1002\/jso.26282 (2020).","journal-title":"J. Surg. Oncol."},{"key":"97233_CR15","doi-asserted-by":"publisher","first-page":"101835","DOI":"10.1016\/j.canep.2020.101835","volume":"69","author":"B Sigurdsson","year":"2020","unstructured":"Sigurdsson, B. et al. A nationwide study on hepatocellular carcinoma. Cancer Epidemiol. 69, 101835. https:\/\/doi.org\/10.1016\/j.canep.2020.101835 (2020).","journal-title":"Cancer Epidemiol."},{"key":"97233_CR16","first-page":"1238","volume":"21","author":"IR Wanless","year":"1995","unstructured":"Wanless, I. R. et al. Hepatic and portal vein thrombosis in cirrhosis: Possible role in development of parenchymal extinction and portal hypertension. Hepatology (Baltimore, MD) 21, 1238\u20131247 (1995).","journal-title":"Hepatology (Baltimore, MD)"},{"key":"97233_CR17","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s11239-010-0460-x","volume":"30","author":"G Lippi","year":"2010","unstructured":"Lippi, G., Cervellin, G., Franchini, M. & Favaloro, E. J. Biochemical markers for the diagnosis of venous thromboembolism: The past, present and future. J. Thromb. Thrombolysis 30, 459\u2013471. https:\/\/doi.org\/10.1007\/s11239-010-0460-x (2010).","journal-title":"J. Thromb. Thrombolysis"},{"key":"97233_CR18","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1002\/ajh.2830380203","volume":"38","author":"K Deguchi","year":"1991","unstructured":"Deguchi, K. et al. Dynamic fluctuations in blood of thrombin\/antithrombin III complex (TAT). Am. J. Hematol. 38, 86\u201389. https:\/\/doi.org\/10.1002\/ajh.2830380203 (1991).","journal-title":"Am. J. Hematol."},{"key":"97233_CR19","doi-asserted-by":"publisher","first-page":"107602962098266","DOI":"10.1177\/1076029620982666","volume":"26","author":"W Ren","year":"2020","unstructured":"Ren, W. et al. Evaluation of coagulation, fibrinolysis and endothelial biomarkers in cirrhotic patients with or without portal venous thrombosis. Clin. Appl. Thrombosis Hemostasis 26, 1076029620982666. https:\/\/doi.org\/10.1177\/1076029620982666 (2020).","journal-title":"Clin. Appl. Thrombosis Hemostasis"},{"key":"97233_CR20","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","volume":"69","author":"European Association for the Study of the, L","year":"2018","unstructured":"European Association for the Study of the, L. EASL clinical practice guidelines: Management of hepatocellular carcinoma. J. Hepatol. 69, 182\u2013236. https:\/\/doi.org\/10.1016\/j.jhep.2018.03.019 (2018).","journal-title":"J. Hepatol."},{"key":"97233_CR21","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1007\/s11894-014-0372-6","volume":"16","author":"A Bonder","year":"2014","unstructured":"Bonder, A. & Afdhal, N. Utilization of FibroScan in clinical practice. Curr. Gastroenterol. Rep. 16, 372. https:\/\/doi.org\/10.1007\/s11894-014-0372-6 (2014).","journal-title":"Curr. Gastroenterol. Rep."},{"key":"97233_CR22","doi-asserted-by":"publisher","first-page":"5074","DOI":"10.1038\/s41598-021-84476-3","volume":"11","author":"A Rosell","year":"2021","unstructured":"Rosell, A. et al. Prognostic value of circulating markers of neutrophil activation, neutrophil extracellular traps, coagulation and fibrinolysis in patients with terminal cancer. Sci. Rep. 11, 5074. https:\/\/doi.org\/10.1038\/s41598-021-84476-3 (2021).","journal-title":"Sci. Rep."},{"key":"97233_CR23","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15003","author":"C Th\u00e5lin","year":"2020","unstructured":"Th\u00e5lin, C. et al. Quantification of citrullinated histones: Development of an improved assay to reliably quantify nucleosomal H3Cit in human plasma. J. Thrombosis Haemostas. https:\/\/doi.org\/10.1111\/jth.15003 (2020).","journal-title":"J. Thrombosis Haemostas."},{"key":"97233_CR24","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nm.1959","volume":"15","author":"K Kessenbrock","year":"2009","unstructured":"Kessenbrock, K. et al. Netting neutrophils in autoimmune small-vessel vasculitis. Nat. Med. 15, 623\u2013625. https:\/\/doi.org\/10.1038\/nm.1959 (2009).","journal-title":"Nat. Med."},{"key":"97233_CR25","doi-asserted-by":"publisher","first-page":"13076","DOI":"10.1073\/pnas.1200419109","volume":"109","author":"M Demers","year":"2012","unstructured":"Demers, M. et al. Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis. Proc. Natl. Acad. Sci. USA 109, 13076\u201313081. https:\/\/doi.org\/10.1073\/pnas.1200419109 (2012).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"97233_CR26","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3324\/haematol.2019.217083","volume":"105","author":"Y Hisada","year":"2020","unstructured":"Hisada, Y. et al. Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors. Haematologica 105, 218\u2013225. https:\/\/doi.org\/10.3324\/haematol.2019.217083 (2020).","journal-title":"Haematologica"},{"key":"97233_CR27","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1111\/jth.12571","volume":"12","author":"AS Savchenko","year":"2014","unstructured":"Savchenko, A. S. et al. Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development. J. Thrombosis Haemostasis 12, 860\u2013870. https:\/\/doi.org\/10.1111\/jth.12571 (2014).","journal-title":"J. Thrombosis Haemostasis"},{"key":"97233_CR28","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1016\/j.jhep.2015.07.004","volume":"63","author":"M Bernardi","year":"2015","unstructured":"Bernardi, M., Moreau, R., Angeli, P., Schnabl, B. & Arroyo, V. Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis. J. Hepatol. 63, 1272\u20131284. https:\/\/doi.org\/10.1016\/j.jhep.2015.07.004 (2015).","journal-title":"J. Hepatol."},{"key":"97233_CR29","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jhepr.2019.06.002","volume":"1","author":"A Blasi","year":"2019","unstructured":"Blasi, A. et al. Plasma levels of circulating DNA are associated with outcome, but not with activation of coagulation in decompensated cirrhosis and ACLF. JHEP Rep. Innov. Hepatol. 1, 179\u2013187. https:\/\/doi.org\/10.1016\/j.jhepr.2019.06.002 (2019).","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"97233_CR30","doi-asserted-by":"publisher","first-page":"e12714","DOI":"10.1111\/sji.12714","volume":"88","author":"JM Agraz-Cibri\u00e1n","year":"2018","unstructured":"Agraz-Cibri\u00e1n, J. M. et al. Impaired neutrophil extracellular traps and inflammatory responses in the peritoneal fluid of patients with liver cirrhosis. Scand. J. Immunol. 88, e12714. https:\/\/doi.org\/10.1111\/sji.12714 (2018).","journal-title":"Scand. J. Immunol."},{"key":"97233_CR31","doi-asserted-by":"publisher","first-page":"512","DOI":"10.3855\/jidc.7165","volume":"10","author":"JM Agraz-Cibrian","year":"2016","unstructured":"Agraz-Cibrian, J. M., Segura-Ortega, J. E., Delgado-Rizo, V. & Fafutis-Morris, M. Alterations in neutrophil extracellular traps is associated with the degree of decompensation of liver cirrhosis. J. Infect. Dev. Ctries. 10, 512\u2013517. https:\/\/doi.org\/10.3855\/jidc.7165 (2016).","journal-title":"J. Infect. Dev. Ctries."},{"key":"97233_CR32","doi-asserted-by":"publisher","first-page":"597648","DOI":"10.3389\/fendo.2020.597648","volume":"11","author":"C Luci","year":"2020","unstructured":"Luci, C., Bourinet, M., Leclere, P. S., Anty, R. & Gual, P. Chronic inflammation in non-alcoholic steatohepatitis: Molecular mechanisms and therapeutic strategies. Front Endocrinol. (Lausanne) 11, 597648. https:\/\/doi.org\/10.3389\/fendo.2020.597648 (2020).","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"97233_CR33","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.cgh.2015.07.019","volume":"14","author":"S Mittal","year":"2016","unstructured":"Mittal, S. et al. Hepatocellular carcinoma in the absence of cirrhosis in United States veterans is associated with nonalcoholic fatty liver disease. Clin. Gastroenterol. Hepatol. 14, 124\u2013131. https:\/\/doi.org\/10.1016\/j.cgh.2015.07.019 (2016).","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"97233_CR34","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jhep.2015.07.040","volume":"64","author":"European Association for the Study of the Liver","year":"2016","unstructured":"European Association for the Study of the Liver. Electronic address, e. e. e. EASL Clinical Practice Guidelines: Vascular diseases of the liver. J. Hepatol. 64, 179\u2013202. https:\/\/doi.org\/10.1016\/j.jhep.2015.07.040 (2016).","journal-title":"J. Hepatol."},{"key":"97233_CR35","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/lt.21941","volume":"16","author":"MJ Englesbe","year":"2010","unstructured":"Englesbe, M. J. et al. Portal vein thrombosis and survival in patients with cirrhosis. Liver Transplant. 16, 83\u201390. https:\/\/doi.org\/10.1002\/lt.21941 (2010).","journal-title":"Liver Transplant."},{"key":"97233_CR36","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1053\/j.gastro.2012.07.018","volume":"143","author":"E Villa","year":"2012","unstructured":"Villa, E. et al. Enoxaparin prevents portal vein thrombosis and liver decompensation in patients with advanced cirrhosis. Gastroenterology 143, 1253-1260.e1254. https:\/\/doi.org\/10.1053\/j.gastro.2012.07.018 (2012).","journal-title":"Gastroenterology"},{"key":"97233_CR37","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.phrs.2016.08.008","volume":"123","author":"AA Manfredi","year":"2017","unstructured":"Manfredi, A. A., Rovere-Querini, P., D\u2019Angelo, A. & Maugeri, N. Low molecular weight heparins prevent the induction of autophagy of activated neutrophils and the formation of neutrophil extracellular traps. Pharmacol. Res. 123, 146\u2013156. https:\/\/doi.org\/10.1016\/j.phrs.2016.08.008 (2017).","journal-title":"Pharmacol. Res."},{"key":"97233_CR38","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.dld.2016.12.019","volume":"49","author":"A Zanetto","year":"2017","unstructured":"Zanetto, A. et al. Thromboelastometry hypercoagulable profiles and portal vein thrombosis in cirrhotic patients with hepatocellular carcinoma. Digest. Liver Disease 49, 440\u2013445. https:\/\/doi.org\/10.1016\/j.dld.2016.12.019 (2017).","journal-title":"Digest. Liver Disease"},{"key":"97233_CR39","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.thromres.2016.05.021","volume":"143","author":"E Campello","year":"2016","unstructured":"Campello, E. et al. Hypercoagulability detected by circulating microparticles in patients with hepatocellular carcinoma and cirrhosis. Thromb. Res. 143, 118\u2013121. https:\/\/doi.org\/10.1016\/j.thromres.2016.05.021 (2016).","journal-title":"Thromb. Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-97233-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-97233-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-97233-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T10:24:42Z","timestamp":1670063082000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-97233-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,9]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["97233"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-97233-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,9]]},"assertion":[{"value":"8 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18025"}}