{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,12,4]],"date-time":"2022-12-04T05:54:26Z","timestamp":1670133266320},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rising morbidity amongst hospitalized patients. Whilst clinical protocols for the management of individual DRESS cases have been well established, determination of potential prevention of these cases by utilizing novel \u201cavoidability\u201d tools has remained unexplored. This retrospective study reviewed records of patients who presented to the emergency department of Weill Cornell Medicine-affiliated Hamad General Hospital, Doha Qatar with suspected DRESS syndrome. These cases were independently adjudicated (utilizing the RegiSCAR, and JSCAR tools) as DRESS-drug pairs by a team of two clinical pharmacists and two General Physicians. They were then rated for potential avoidability with the Liverpool adverse drug reactions avoidability tool (LAAT) by the same team of raters. A total of 16 patients satisfied RegiSCAR criteria for DRESS syndrome. The mean age of the study population was 41.5\u00a0years (SD\u2009\u00b1\u200913.3). The study population was predominantly male (n\u2009=\u200912; [75%]). The median latent period from drug ingestion to clinical presentation was 14\u00a0days (interquartile range [IQR] 6.5, 29). The median RegiSCAR and J-SCAR scores were 6 (IQR 5, 6.8), 5 (IQR 4, 5.8) respectively. Utilizing the LAAT, about 60% of the DRESS syndrome-drug pairs were rated as \u201cavoidable\u201d (\u201cprobable\u201d or \u201cdefinite\u201d). The overall Krippendorf\u2019s alpha with the LAAT was 0.81 (SE 0.10, CI 0.59\u20131.00); with an intraclass correlation coefficient (ICC) of 0.90 (CI 0.77, 0.96.). In a randomly selected cohort of DRESS syndrome-drug pairs, a significant proportion was potentially avoidable (\u201cpossibly\u201d and \u201cdefinitely\u201d) utilizing the LAAT. This will need validation by larger sample-sized prospective studies utilizing the updated LAAT proposed by this study.<\/jats:p>","DOI":"10.1038\/s41598-021-97381-6","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T10:06:24Z","timestamp":1631181984000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An investigation into the avoidability of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome"],"prefix":"10.1038","volume":"11","author":[{"given":"Mohammed Ibn-Mas\u2019ud","family":"Danjuma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina Mohammad Ahmad","family":"Naseralallah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bodoor","family":"AbouJabal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouhand Faisal","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim Y.","family":"Abubeker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Layla Abdul","family":"Jabbar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelnaser","family":"Elzouki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"issue":"5","key":"97381_CR1","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1111\/bjd.12501","volume":"169","author":"SH Kardaun","year":"2013","unstructured":"Kardaun, S. H. et al. Drug reaction with eosinophilia and systemic symptoms (DRESS): An original multisystem adverse drug reaction. Results from the prospective RegiSCAR study. Br. J. Dermatol. 169(5), 1071\u20131080 (2013).","journal-title":"Br. J. Dermatol."},{"key":"97381_CR2","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1111\/j.1365-2133.2007.07807.x","volume":"156","author":"T Shiohara","year":"2007","unstructured":"Shiohara, T., Iijima, M., Ikezawa, Z. & Hashimoto, K. The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations. Br. J. Dermatol. Engl. 156, 1083\u20131084 (2007).","journal-title":"Br. J. Dermatol. Engl."},{"issue":"2","key":"97381_CR3","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.jaip.2018.08.013","volume":"7","author":"AR Wolfson","year":"2019","unstructured":"Wolfson, A. R. et al. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome identified in the electronic health record allergy module. J. Allergy Clin. Immunol. Pract. 7(2), 633\u2013640 (2019).","journal-title":"J. Allergy Clin. Immunol. Pract."},{"issue":"2","key":"97381_CR4","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/bcp.13096","volume":"83","author":"E Ram\u00edrez","year":"2017","unstructured":"Ram\u00edrez, E. et al. Eosinophilic drug reactions detected by a prospective pharmacovigilance programme in a tertiary hospital. Br. J. Clin. Pharmacol. 83(2), 400\u2013415 (2017).","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"7","key":"97381_CR5","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.amjmed.2011.01.017","volume":"124","author":"P Cacoub","year":"2011","unstructured":"Cacoub, P. et al. The DRESS syndrome: A literature review. Am. J. Med. 124(7), 588\u2013597 (2011).","journal-title":"Am. J. 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