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Distinct clusters of microbiomes and AMR determinants were observed at D.8 when<jats:italic>Prevotella<\/jats:italic>(20.9%) was the major genus, whereas at D.\u2009\u2212\u20093\u2013D.3,<jats:italic>Alistipes<\/jats:italic>(6.9\u201312.7%) and<jats:italic>Bacteroides<\/jats:italic>(5.2\u20138.5%) were the major genera.<jats:italic>Lactobacillus<\/jats:italic>and<jats:italic>Escherichia<\/jats:italic>were notably observed at D.\u2009\u2212\u20093 (1.2%) and D.\u2009\u2212\u20093\u2013D.3 (0.2\u20130.4%), respectively. For AMR, a distinct cluster of AMR determinants was observed at D.8, mainly conferring resistance to macrolide\u2013lincosamide\u2013streptogramin (<jats:italic>mef<\/jats:italic>A), \u03b2-lactam (<jats:italic>cfx<\/jats:italic>A6 and<jats:italic>aci<\/jats:italic>1) and phenicol (<jats:italic>rlm<\/jats:italic>N). In contrast, at D.\u2009\u2212\u20093\u2013D.3, a high abundance of determinants with aminoglycoside (AMG) (<jats:italic>sat<\/jats:italic>,<jats:italic>aac<\/jats:italic>(6')<jats:italic>-aph<\/jats:italic>(2''),<jats:italic>aad<\/jats:italic>A and<jats:italic>acr<\/jats:italic>F), \u03b2-lactam (<jats:italic>fus<\/jats:italic>-1,<jats:italic>cep<\/jats:italic>A and<jats:italic>mrd<\/jats:italic>A), multidrug resistance (MDR) (<jats:italic>gad<\/jats:italic>W,<jats:italic>mdt<\/jats:italic>E<jats:italic>, emr<\/jats:italic>A,<jats:italic>evg<\/jats:italic>S<jats:italic>, tol<\/jats:italic>C and<jats:italic>mdt<\/jats:italic>B), phenicol (<jats:italic>cat<\/jats:italic>B4 and<jats:italic>cml<\/jats:italic>A4), and sulfonamide patterns (<jats:italic>sul<\/jats:italic>3) was observed. Canonical correlation analysis (CCA) plot associated<jats:italic>Escherichia coli<\/jats:italic>with<jats:italic>aac<\/jats:italic>(6')<jats:italic>-aph<\/jats:italic>(2''),<jats:italic>emr<\/jats:italic>A,<jats:italic>mdt<\/jats:italic>B,<jats:italic>cat<\/jats:italic>B4 and<jats:italic>cml<\/jats:italic>A4 at D.\u2009\u2212\u20093, D.0 and\/or D.3 whereas at D.8 associations between<jats:italic>Prevotella<\/jats:italic>and<jats:italic>mef<\/jats:italic>A,<jats:italic>cfx<\/jats:italic>A6 and<jats:italic>aci<\/jats:italic>1 were identified. The weaning age and diet factor played an important role in the microbial community composition.<\/jats:p>","DOI":"10.1038\/s41598-021-97586-9","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T10:02:45Z","timestamp":1631268165000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Dynamics of the fecal microbiome and antimicrobial resistome in commercial piglets during the weaning period"],"prefix":"10.1038","volume":"11","author":[{"given":"Prapat","family":"Suriyaphol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy Ka Ho","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathamon","family":"Yimpring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paiboon","family":"Tunsagool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuttichai","family":"Mhuantong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rungtip","family":"Chuanchuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Bessarab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan B. 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