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To date, however, no studies have objectively measured the effects of anti-adhesion agents on cervical adhesion symptoms. This study evaluated the effects of an anti-adhesion agent on cervical adhesions after thyroid surgery, as determined using a system that measures the extent of marker movement objectively. One hundred patients were randomized in a 1:1 ratio to undergo thyroid surgery with or without the anti-adhesion agent Collabarrier. Using specially manufactured recording equipment, the position of the marker on neck skin was measured before surgery, and 2\u00a0weeks, 3\u00a0months, and 9\u00a0months after surgery. Relative change in marker distance, calculated by subtracting the marker position before surgery from the marker positions 2\u00a0weeks, 3\u00a0months, and 9\u00a0months after surgery, differed significantly in the groups of patients who underwent thyroid surgery with and without the anti-adhesion agent (P\u2009&lt;\u20090.05). A novel measuring system can objectively evaluate the effectiveness of a thyroid anti-adhesion agent. The anti-adhesion agent used significantly reduced adhesions compared with the control group. The trial is registered at\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cris.nih.go.kr\">www.cris.nih.go.kr<\/jats:ext-link>\n                    (KCT0005745; date of registration, 08\/01\/2021).\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-97919-8","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T06:25:59Z","timestamp":1633587959000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of an anti-adhesion agent on vision-based assessment of cervical adhesions after thyroid surgery: randomized, placebo-controlled trial"],"prefix":"10.1038","volume":"11","author":[{"given":"Hyeong Won","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongheon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keunchul","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Jun","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Chan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"97919_CR1","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1053\/j.sult.2011.12.005","volume":"33","author":"BA Policeni","year":"2012","unstructured":"Policeni, B. 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