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However, long-term effects of this nutritional approach are still debated, and it has been demonstrated that cerebral growth depends on protein intake in early life. A negative impact of early high energy intake by parenteral nutrition (PN) has been reported for patients in critically ill conditions, observed in intensive care unit. We aimed at evaluating the impact of energy intake on cerebral growth in preterm neonates early in life. We included preterm newborns with gestational age\u2009&lt;\u200932\u00a0weeks or birth weight (BW)\u2009&lt;\u20091500\u00a0g. Measurement of cerebral structures was performed by cranial Ultrasonography (cUS) between 3 and 7\u00a0days of life (DOL, T0) and at 28 DOL (T1). We evaluated the relation between energy intake and cerebral growth in the first 28 DOL. We observed in 109 preterm newborns a significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) negative correlation between energy intake received by PN and right caudate head growth (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212 0.243*) and a positive correlation between total energy intake and transverse cerebellum diameter (<jats:italic>r<\/jats:italic>\u2009=\u20090.254*). Multivariate analysis showed that energy intake administered by enteral nutrition (EN), independently increased growth of left caudate head (\u03b2\u2009=\u20090.227*) and height cerebellar vermis (\u03b2\u2009=\u20090.415*), while PN independently affected growth of both right and left caudate head (\u03b2\u2009=\u2009\u2212 0.164* and \u03b2\u2009=\u2009\u2212 0.228*, respectively) and cerebellum transverse diameter (\u03b2\u2009=\u2009\u2212 0.849*). The route of energy administration may exert different effects on cerebral growth in early life. High energy intake administered through EN seems to be positively correlated to cerebral growth; conversely, PN energy intake results in a poorer cerebral growth evaluated with cUS.<\/jats:p>","DOI":"10.1038\/s41598-021-98088-4","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T10:03:34Z","timestamp":1631786614000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effects of early energy intake on neonatal cerebral growth of preterm newborn: an observational study"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2481-0692","authenticated-orcid":false,"given":"Giovanni","family":"Boscarino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1316-4130","authenticated-orcid":false,"given":"Maria","family":"Di Chiara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Cellitti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"De Nardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8659-4652","authenticated-orcid":false,"given":"Maria Giulia","family":"Conti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9042-8120","authenticated-orcid":false,"given":"Pasquale","family":"Parisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8455-796X","authenticated-orcid":false,"given":"Alberto","family":"Spalice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Di Mario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Ronchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Pangallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-2876","authenticated-orcid":false,"given":"Gianluca","family":"Terrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"key":"98088_CR1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fnut.2017.00020","volume":"4","author":"RK Kumar","year":"2017","unstructured":"Kumar, R. 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