{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:26:58Z","timestamp":1768588018674,"version":"3.49.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Catheter ablation is an important non-pharmacological intervention for atrial fibrillation (AF), but its effect on the incidence of asymptomatic cerebral emboli and long-term effects on cognitive function remain unknown. We prospectively enrolled 101 patients who underwent AF ablation. Brain magnetic resonance imaging (MRI) (72 patients) and neuropsychological assessments (66 patients) were performed 1\u20133\u00a0days (baseline) and 6\u00a0months after ablation. Immediately after ablation, diffusion-weighted MRI and 3-dimensional double inversion recovery (3D-DIR) detected embolic microinfarctions in 63 patients (87.5%) and 62 patients (86.1%), respectively. After 6\u00a0months, DIR lesions disappeared in 41 patients. Microbleeds (MBs) increased by 17%, and 65% of the de novo MBs were exactly at the same location as the microinfarctions. Average Mini-Mental State Examination scores improved from 27.9\u2009\u00b1\u20092.4 to 28.5\u2009\u00b1\u20091.7 (<jats:italic>p<\/jats:italic>\u2009=\u20090.037), and detailed neuropsychological assessment scores showed improvement in memory, constructional, and frontal lobe functions. Ejection fraction, left atrial volume index and brain natriuretic peptide level improved from baseline to 3\u20136\u00a0months after ablation. Despite incidental microemboli, cognitive function was preserved 6\u00a0months after ablation.<\/jats:p>","DOI":"10.1038\/s41598-021-98484-w","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T10:57:49Z","timestamp":1632394669000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation"],"prefix":"10.1038","volume":"11","author":[{"given":"Natsuko","family":"Kato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Muraga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Shindo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Ii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Shiga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-ichi","family":"Tabei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Fukuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Kagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eitaro","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Umino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Sakuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Tomimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"key":"98484_CR1","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1016\/S0140-6736(05)67889-0","volume":"366","author":"CP Ferri","year":"2005","unstructured":"Ferri, C. P. et al. Global prevalence of dementia: A Delphi consensus study. Lancet 366, 2112\u20132117 (2005).","journal-title":"Lancet"},{"key":"98484_CR2","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1212\/01.wnl.0000341271.90478.8e","volume":"72","author":"A Viswanathan","year":"2009","unstructured":"Viswanathan, A., Rocca, W. A. & Tzourio, C. Vascular risk factors and dementia: How to move forward?. Neurology 72, 368\u2013374 (2009).","journal-title":"Neurology"},{"key":"98484_CR3","doi-asserted-by":"publisher","first-page":"427","DOI":"10.3233\/JAD-160527","volume":"54","author":"M Vijayan","year":"2016","unstructured":"Vijayan, M. & Reddy, P. H. Stroke, vascular dementia, and Alzheimer\u2019s disease: Molecular links. J. Alzheimers Dis. 54, 427\u2013443 (2016).","journal-title":"J. Alzheimers Dis."},{"key":"98484_CR4","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1161\/01.STR.0000166053.83476.4a","volume":"36","author":"C Marini","year":"2005","unstructured":"Marini, C. et al. Contribution of atrial fibrillation to incidence and outcome of ischemic stroke: results from a population-based study. Stroke 36, 1115\u20131119 (2005).","journal-title":"Stroke"},{"key":"98484_CR5","doi-asserted-by":"publisher","first-page":"338","DOI":"10.7326\/0003-4819-158-5-201303050-00007","volume":"158","author":"S Kalantarian","year":"2013","unstructured":"Kalantarian, S., Stern, T. A., Mansour, M. & Ruskin, J. N. Cognitive impairment associated with atrial fibrillation: a meta-analysis. Ann. Intern. Med. 158, 338\u2013346 (2013).","journal-title":"Ann. Intern. Med."},{"key":"98484_CR6","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/j.hrthm.2012.07.026","volume":"9","author":"P Santangeli","year":"2012","unstructured":"Santangeli, P. et al. Atrial fibrillation and the risk of incident dementia: A meta-analysis. Heart Rhythm 9, 1761\u20131768 (2012).","journal-title":"Heart Rhythm"},{"key":"98484_CR7","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1159\/000342195","volume":"34","author":"F Cacciatore","year":"2012","unstructured":"Cacciatore, F. et al. Role of ventricular rate response on dementia in cognitively impaired elderly subjects with atrial fibrillation: A 10-year study. Dement. Geriatr. Cogn. Disord. 34, 143\u2013148 (2012).","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"98484_CR8","doi-asserted-by":"crossref","first-page":"e007301","DOI":"10.1161\/JAHA.117.007301","volume":"7","author":"LY Chen","year":"2018","unstructured":"Chen, L. Y. et al. Association of atrial fibrillation with cognitive decline and dementia over 20 years: The ARIC-NCS (Atherosclerosis Risk in Communities Neurocognitive Study). J. Am. Heart Assoc. 7, e007301 (2018).","journal-title":"J. Am. Heart Assoc."},{"key":"98484_CR9","doi-asserted-by":"publisher","first-page":"e1732","DOI":"10.1212\/WNL.0000000000006456","volume":"91","author":"M Ding","year":"2018","unstructured":"Ding, M. et al. Atrial fibrillation, antithrombotic treatment, and cognitive aging: A population-based study. Neurology 91, e1732\u2013e1740 (2018).","journal-title":"Neurology"},{"key":"98484_CR10","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1001\/archinte.1995.00430050045005","volume":"155","author":"WM Feinberg","year":"1995","unstructured":"Feinberg, W. M., Blackshear, J. L., Laupacis, A., Kronmal, R. & Hart, R. G. Prevalence, age distribution, and gender of patients with atrial fibrillation. Analysis and implications. Arch. Intern. Med. 155, 469\u2013473 (1995).","journal-title":"Arch. Intern. Med."},{"key":"98484_CR11","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1111\/j.1540-8167.2011.02035.x","volume":"22","author":"TJ Bunch","year":"2011","unstructured":"Bunch, T. J. et al. Patients treated with catheter ablation for atrial fibrillation have long-term rates of death, stroke, and dementia similar to patients without atrial fibrillation. J. Cardiovasc. Electrophysiol. 22, 839\u2013845 (2011).","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"98484_CR12","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1093\/eurheartj\/ehx579","volume":"39","author":"L Friberg","year":"2018","unstructured":"Friberg, L. & Rosenqvist, M. Less dementia with oral anticoagulation in atrial fibrillation. Eur. Heart J. 39, 453\u2013460 (2018).","journal-title":"Eur. Heart J."},{"key":"98484_CR13","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1212\/WNL.0b013e31820f2e38","volume":"76","author":"CS Kwok","year":"2011","unstructured":"Kwok, C. S., Loke, Y. K., Hale, R., Potter, J. F. & Myint, P. K. Atrial fibrillation and incidence of dementia: A systematic review and meta-analysis. Neurology 76, 914\u2013922 (2011).","journal-title":"Neurology"},{"key":"98484_CR14","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1016\/j.cjca.2017.09.024","volume":"33","author":"L Rivard","year":"2017","unstructured":"Rivard, L. & Khairy, P. Mechanisms, clinical significance, and prevention of cognitive impairment in patients with atrial fibrillation. Can. J. Cardiol. 33, 1556\u20131564 (2017).","journal-title":"Can. J. Cardiol."},{"key":"98484_CR15","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/S1474-4422(19)30079-1","volume":"18","author":"JM Wardlaw","year":"2019","unstructured":"Wardlaw, J. M., Smith, C. & Dichgans, M. Small vessel disease: Mechanisms and clinical implications. Lancet Neurol. 18, 684\u2013696 (2019).","journal-title":"Lancet Neurol."},{"key":"98484_CR16","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1161\/STROKEAHA.12.679381","volume":"44","author":"H Stefansdottir","year":"2013","unstructured":"Stefansdottir, H. et al. Atrial fibrillation is associated with reduced brain volume and cognitive function independent of cerebral infarcts. Stroke 44, 1020\u20131025 (2013).","journal-title":"Stroke"},{"key":"98484_CR17","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1016\/j.jacc.2005.07.040","volume":"46","author":"MK Chung","year":"2005","unstructured":"Chung, M. K. et al. Functional status in rate-versus rhythm-control strategies for atrial fibrillation: Results of the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Functional Status Substudy. J. Am. Coll. Cardiol. 46, 1891\u20131899 (2005).","journal-title":"J. Am. Coll. Cardiol."},{"key":"98484_CR18","doi-asserted-by":"publisher","first-page":"100386","DOI":"10.1016\/j.cpcardiol.2018.07.001","volume":"44","author":"V Chinta","year":"2019","unstructured":"Chinta, V. et al. Atrial fibrillation and deterioration in cognitive function. Curr. Probl. Cardiol. 44, 100386 (2019).","journal-title":"Curr. Probl. Cardiol."},{"key":"98484_CR19","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/pace.12336","volume":"37","author":"FM Merchant","year":"2014","unstructured":"Merchant, F. M. & Delurgio, D. B. Catheter ablation of atrial fibrillation and risk of asymptomatic cerebral embolism. Pacing Clin. Electrophysiol. 37, 389\u2013397 (2014).","journal-title":"Pacing Clin. Electrophysiol."},{"key":"98484_CR20","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1007\/s00392-014-0777-0","volume":"104","author":"S Kochhauser","year":"2015","unstructured":"Kochhauser, S. et al. Neuropsychological impact of cerebral microemboli in ablation of atrial fibrillation. Clin. Res. Cardiol. 104, 234\u2013240 (2015).","journal-title":"Clin. Res. Cardiol."},{"key":"98484_CR21","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00380-019-01475-1","volume":"35","author":"Y Kagawa","year":"2020","unstructured":"Kagawa, Y., Fujii, E., Fujita, S. & Ito, M. Association between left atrial reverse remodeling and maintenance of sinus rhythm after catheter ablation of persistent atrial fibrillation. Heart Vessels 35, 239\u2013245 (2020).","journal-title":"Heart Vessels"},{"key":"98484_CR22","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1552-6569.2012.00722.x","volume":"23","author":"Y Ii","year":"2013","unstructured":"Ii, Y. et al. In vivo detection of cortical microinfarcts on ultrahigh-field MRI. J. Neuroimaging 23, 28\u201332 (2013).","journal-title":"J. Neuroimaging"},{"key":"98484_CR23","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1007\/s00415-019-09350-9","volume":"266","author":"Y Ii","year":"2019","unstructured":"Ii, Y. et al. Cortical microinfarcts in patients with multiple lobar microbleeds on 3 T MRI. J. Neurol. 266, 1887\u20131896 (2019).","journal-title":"J. Neurol."},{"key":"98484_CR24","first-page":"93","volume-title":"The Mental Status Examination in Neurology","author":"RL Strub","year":"2000","unstructured":"Strub, R. L. & Black, F. W. The Mental Status Examination in Neurology 4th edn, 93\u2013115 (FA Davis Company, 2000).","edition":"4"},{"key":"98484_CR25","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1159\/000449245","volume":"6","author":"M Satoh","year":"2016","unstructured":"Satoh, M. et al. Improved Necker cube drawing-based assessment battery for constructional apraxia: The Mie Constructional Apraxia Scale (MCAS). Dement. Geriatr. Cogn. Dis. Extra. 6, 424\u2013436 (2016).","journal-title":"Dement. Geriatr. Cogn. Dis. Extra."},{"key":"98484_CR26","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3233\/JAD-161217","volume":"57","author":"M Satoh","year":"2017","unstructured":"Satoh, M. et al. Physical exercise with music maintains activities of daily living in patients with dementia: Mihama-Kiho Project Part 21. J. Alzheimers Dis. 57, 85\u201396 (2017).","journal-title":"J. Alzheimers Dis."},{"key":"98484_CR27","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.jacc.2018.10.077","volume":"73","author":"HC Diener","year":"2019","unstructured":"Diener, H. C., Hart, R. G., Koudstaal, P. J., Lane, D. A. & Lip, G. Y. H. Atrial fibrillation and cognitive function: JACC review topic of the week. J. Am. Coll. Cardiol. 73, 612\u2013619 (2019).","journal-title":"J. Am. Coll. Cardiol."},{"key":"98484_CR28","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/S0197-4580(00)00111-1","volume":"21","author":"JC de la Torre","year":"2000","unstructured":"de la Torre, J. C. Critically attained threshold of cerebral hypoperfusion: The CATCH hypothesis of Alzheimer\u2019s pathogenesis. Neurobiol. Aging. 21, 331\u2013342 (2000).","journal-title":"Neurobiol. Aging."},{"key":"98484_CR29","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1161\/01.STR.22.5.609","volume":"22","author":"J Kawamura","year":"1991","unstructured":"Kawamura, J., Meyer, J. S., Terayama, Y. & Weathers, S. Leukoaraiosis correlates with cerebral hypoperfusion in vascular dementia. Stroke 22, 609\u2013614 (1991).","journal-title":"Stroke"},{"key":"98484_CR30","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1111\/jce.13261","volume":"28","author":"S Aldrugh","year":"2017","unstructured":"Aldrugh, S., Sardana, M., Henninger, N., Saczynski, J. S. & McManus, D. D. Atrial fibrillation, cognition and dementia: A review. J. Cardiovasc. Electrophysiol. 28, 958\u2013965 (2017).","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"98484_CR31","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1093\/europace\/eux220","volume":"20","author":"M Gardarsdottir","year":"2018","unstructured":"Gardarsdottir, M. et al. Atrial fibrillation is associated with decreased total cerebral blood flow and brain perfusion. Europace 20, 1252\u20131258 (2018).","journal-title":"Europace"},{"key":"98484_CR32","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/jcbfm.1989.62","volume":"9","author":"P Petersen","year":"1989","unstructured":"Petersen, P., Kastrup, J., Videbaek, R. & Boysen, G. Cerebral blood flow before and after cardioversion of atrial fibrillation. J. Cereb. Blood Flow Metab. 9, 422\u2013425 (1989).","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"98484_CR33","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1177\/0271678X16641128","volume":"37","author":"M Wirth","year":"2017","unstructured":"Wirth, M. et al. Divergent regional patterns of cerebral hypoperfusion and gray matter atrophy in mild cognitive impairment patients. J. Cereb. Blood Flow Metab. 37, 814\u2013824 (2017).","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"98484_CR34","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1749-6632.2002.tb04794.x","volume":"977","author":"L White","year":"2002","unstructured":"White, L. et al. Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants. Ann. N. Y. Acad. Sci. 977, 9\u201323 (2002).","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"98484_CR35","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1161\/01.STR.0000110791.51378.4E","volume":"35","author":"E Kovari","year":"2004","unstructured":"Kovari, E. et al. Cortical microinfarcts and demyelination significantly affect cognition in brain aging. Stroke 35, 410\u2013414 (2004).","journal-title":"Stroke"},{"key":"98484_CR36","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1212\/01.wnl.0000257094.10655.9a","volume":"68","author":"E Kovari","year":"2007","unstructured":"Kovari, E. et al. Cortical microinfarcts and demyelination affect cognition in cases at high risk for dementia. Neurology 68, 927\u2013931 (2007).","journal-title":"Neurology"},{"key":"98484_CR37","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3389\/fnins.2019.00018","volume":"13","author":"R Silva","year":"2019","unstructured":"Silva, R., Miranda, C. M., Liu, T., Tse, G. & Roever, L. Atrial fibrillation and risk of dementia: Epidemiology, mechanisms, and effect of anticoagulation. Front. Neurosci. 13, 18 (2019).","journal-title":"Front. Neurosci."},{"key":"98484_CR38","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3233\/JAD-151008","volume":"53","author":"Y Ueda","year":"2016","unstructured":"Ueda, Y. et al. Neuropsychological features of microbleeds and cortical microinfarct detected by high resolution magnetic resonance imaging. J. Alzheimers Dis. 53, 315\u2013325 (2016).","journal-title":"J. Alzheimers Dis."},{"key":"98484_CR39","first-page":"560","volume":"26","author":"H Nakamura","year":"2005","unstructured":"Nakamura, H. et al. Effect of thin-section diffusion-weighted MR imaging on stroke diagnosis. AJNR Am. J. Neuroradiol. 26, 560\u2013565 (2005).","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"98484_CR40","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1161\/STROKEAHA.114.008194","volume":"46","author":"M Bergui","year":"2015","unstructured":"Bergui, M. et al. Selective vulnerability of cortical border zone to microembolic infarct. Stroke 46, 1864\u20131869 (2015).","journal-title":"Stroke"},{"key":"98484_CR41","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1001\/jamaneurol.2019.5106","volume":"77","author":"A Ter Telgte","year":"2020","unstructured":"Ter Telgte, A. et al. Temporal dynamics of cortical microinfarcts in cerebral small vessel disease. JAMA Neurol. 77, 643\u2013647 (2020).","journal-title":"JAMA Neurol."},{"key":"98484_CR42","doi-asserted-by":"publisher","first-page":"e018160","DOI":"10.1136\/bmjopen-2017-018160","volume":"8","author":"I Havsteen","year":"2018","unstructured":"Havsteen, I. et al. Small cortical grey matter lesions show no persistent infarction in transient ischaemic attack? A prospective cohort study. BMJ Open 8, e018160 (2018).","journal-title":"BMJ Open"},{"key":"98484_CR43","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1111\/ene.12608","volume":"22","author":"S Horstmann","year":"2015","unstructured":"Horstmann, S. et al. Prevalence of atrial fibrillation and association of previous antithrombotic treatment in patients with cerebral microbleeds. Eur. J. Neurol. 22, 1355\u20131362 (2015).","journal-title":"Eur. J. Neurol."},{"key":"98484_CR44","doi-asserted-by":"publisher","first-page":"e30","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.12.050","volume":"28","author":"A Ito","year":"2019","unstructured":"Ito, A. et al. Small cortical infarcts transformed to lobar cerebral microbleeds: A case series. J. Stroke Cerebrovasc. Dis. 28, e30\u2013e32 (2019).","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"98484_CR45","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1177\/0271678X19835565","volume":"40","author":"S Hilal","year":"2020","unstructured":"Hilal, S. et al. Cortical cerebral microinfarcts predict cognitive decline in memory clinic patients. J. Cereb. Blood Flow Metab. 40, 44\u201353 (2020).","journal-title":"J. Cereb. Blood Flow Metab."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-98484-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-98484-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-98484-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T15:57:27Z","timestamp":1670083047000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-98484-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,23]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["98484"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-98484-w","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,23]]},"assertion":[{"value":"16 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18995"}}