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Female Wistar rats were randomized to receive either sham (control) or 1\u00a0h of WAS for ten consecutive days before the\u00a0evaluation of nocturnal urination pattern in metabolic cages. T<jats:sub>1<\/jats:sub> mapping of urinary bladder wall at 9.4\u00a0T was performed pre- and post- instillation of 4\u00a0mM Gadobutrol in a mixture with 5\u00a0mM Ferumoxytol. Subsequently, either T<jats:sub>1<\/jats:sub> mapping was repeated after brief intravesical PS exposure or the animals were sacrificed for histology and analyzing the\u00a0mucosal levels of mRNA. Compared to the control group, WAS exposure decreased the single void urine volume and shortened the post-contrast T<jats:sub>1<\/jats:sub> relaxation time of mucosa- used to compute relatively higher ingress of instilled Gadobutrol. Compromised permeability in WAS group was corroborated by the urothelial denudation, edema and ZO-1 downregulation. PS exposure doubled the baseline ingress of Gadobutrol in both groups. 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