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This meta-analysis was performed to evaluate whether apparent diffusion coefficient (ADC) from diffusion-weighted imaging (DWI) can predict treatment response of patients with nasopharyngeal carcinoma. A systematic search of PubMed-MEDLINE and Embase was performed to identify relevant original articles until July 22, 2021. We included studies which performed DWI for predicting locoregional treatment response in nasopharyngeal carcinoma treated with neoadjuvant chemotherapy, definitive chemoradiation, or radiation therapy. Hazard ratios were meta-analytically pooled using a random-effects model for the pooled estimates of overall survival, local relapse-free survival, distant metastasis-free survival and their 95% CIs. ADC showed a pooled sensitivity of 87% (95% CI 72\u201394%) and specificity of 70% (95% CI 56\u201380%) for predicting treatment response. Significant between-study heterogeneity was observed for both pooled sensitivity (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200968.5%) and specificity (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200992.2%) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The pooled hazard ratios of low pretreatment ADC for assessing overall survival, local relapse-free survival, and distant metastasis-free survival were 1.42 (95% CI 1.09\u20131.85), 2.31 (95% CI 1.42\u20133.74), and 1.35 (95% CI 1.05\u20131.74), respectively. In patients with nasopharyngeal carcinoma, pretreatment ADC demonstrated good predictive performance for treatment response.<\/jats:p>","DOI":"10.1038\/s41598-021-98508-5","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T10:57:49Z","timestamp":1632394669000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Diffusion-weighted MRI for predicting treatment response in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis"],"prefix":"10.1038","volume":"11","author":[{"given":"Min Kyoung","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangsean","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So-Lyung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"key":"98508_CR1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","volume":"394","author":"Y-P Chen","year":"2019","unstructured":"Chen, Y.-P. et al. 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