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Five different treatment methods, that combine medication therapy with mild hyperthermia by MRI contrast (<jats:inline-formula><jats:alternatives><jats:tex-math>$$\\gamma -{Fe}_{2}{O}_{3}$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mrow>\n                    <mml:mi>\u03b3<\/mml:mi>\n                    <mml:mo>-<\/mml:mo>\n                    <mml:msub>\n                      <mml:mrow>\n                        <mml:mi>Fe<\/mml:mi>\n                      <\/mml:mrow>\n                      <mml:mn>2<\/mml:mn>\n                    <\/mml:msub>\n                    <mml:msub>\n                      <mml:mi>O<\/mml:mi>\n                      <mml:mn>3<\/mml:mn>\n                    <\/mml:msub>\n                  <\/mml:mrow>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula>) and thermal ablation via HIFU, are investigated in detail. A comparison between classical chemotherapy and thermochemistry shows that temperature can improve the therapeutic outcome by stimulating biological properties. On the other hand, the intravascular release of ThermoDox increases the concentration of free drug by 2.6 times compared to classical chemotherapy. The transport of drug in interstitium relies mainly on the diffusion mechanism to be able to penetrate deeper and reach the cancer cells in the inner regions of the tumor. Due to the low drug penetration into the tumor center, thermal ablation has been used for necrosis of the central areas before thermochemotherapy and ThermoDox therapy. Perfusion of the region around the necrotic zone is found to be damaged, while cells in the region are alive and not affected by medication therapy; so, there is a risk of tumor recurrence. Therefore, it is recommended that ablation be performed after the medication therapy. Our model describes a comprehensive assessment of MR-HIFU technology, taking into account many effective details, which can be a reliable guide towards the optimal use of drug delivery systems.<\/jats:p>","DOI":"10.1038\/s41598-021-98554-z","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T11:02:54Z","timestamp":1633086174000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors"],"prefix":"10.1038","volume":"11","author":[{"given":"Mohammad","family":"Souri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madjid","family":"Soltani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshad","family":"Moradi Kashkooli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"key":"98554_CR1","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.7150\/thno.14960","volume":"6","author":"WJ Lokerse","year":"2016","unstructured":"Lokerse, W. 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