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Ten-week-old male Wistar rats were randomly assigned into four groups (n\u2009=\u20096\/group): Control, acetate and obese with or without acetate groups received vehicle (distilled water; <jats:italic>po<\/jats:italic>), acetate (200\u00a0mg\/kg, <jats:italic>po<\/jats:italic>) and 40% HFD with or without acetate respectively. The treatments lasted for 12\u00a0weeks. Obese animals showed increase in body weight, visceral fat mass, insulin and triglyceride-glucose index and a reduction in insulin sensitivity. In addition, obese animals also showed increase in plasma\/hypothalamic and adipose pyruvate dehydrogenase kinase-4, lactate-pyruvate ratio, malondialdehyde, \u03b3-glutamyl transferase, and a decrease in glucose-6-phosphate dehydrogenase, glutathione, nitric oxide and PPAR-\u03b3. HFD also elevated plasma\/hypothalamic lipid and decreased adipose lipid profile, increased hypothalamic and adipose tumor necrosis factor-\u03b1, interleukin-6 and histone deacetylase (HDAC), and elevated plasma\/adipose leptin. These alterations were reversed by concomitant administration of acetate. The present results demonstrate that obesity is characterized by BAMED, which is accompanied by altered HDAC\/PPAR-\u03b3. The results in addition suggest that acetate, an HDAC inhibitor rescues BAMED with consequent normalization of body weight and visceral fat mass by modulation of PPAR-\u03b3 and suppression of oxidative stress.<\/jats:p>","DOI":"10.1038\/s41598-021-98605-5","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T10:57:49Z","timestamp":1632394669000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Acetate rescues defective brain-adipose metabolic network in obese Wistar rats by modulation of peroxisome proliferator-activated receptor-\u03b3"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8229-9688","authenticated-orcid":false,"given":"Kehinde Samuel","family":"Olaniyi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morounkeji Nicole","family":"Owolabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chukwubueze Lucky","family":"Atuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toluwani Bosede","family":"Agunbiade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolanle Yemisi","family":"Alabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"key":"98605_CR1","unstructured":"World Health Organization. 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