{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:51:23Z","timestamp":1740163883141,"version":"3.37.3"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770516","81770516","81770516"],"award-info":[{"award-number":["81770516","81770516","81770516"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Natural Science Foundation of Fujian Province","award":["2019J01449"],"award-info":[{"award-number":["2019J01449"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the effect of duodenal-jejunal bypass (DJB) surgery on postoperative blood glucose in type 2 diabetic rats, and further explore possible mechanisms for the effect of surgical treatment of type 2 diabetes. Forty rats with type 2 diabetes were randomly assigned to 4 groups (n\u2009=\u200910 rats per group), which subsequently underwent DJB, new biliopancreatic diversion (NBPD) or duodenal-jejunal exclusion (DJE) surgery or a sham operation (SHAM). Fasting glucose, 2-h postprandial glucose and blood lipids were measured, and the mRNA in liver and intestinal tissue for bile acid receptor (FXR), as well as the FXR protein expression in the liver tissues were determined. Postprandial blood glucose and fasting TG and FFA in the DJB and NBPD groups were significantly lower than those in the SHAM group and preoperative (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) at 8\u00a0weeks postoperation. Liver FXR protein was expressed at significantly higher in the DJB and NBPD groups than in the other two (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and the intestinal FXR mRNA in the DJE group were highest. DJB up-regulates the expression of bile acid receptors in the liver and down-regulates those receptors in the intestinal tract via biliopancreatic diversion. This process reduces TG levels, and subsequently any lipotoxicity to islet cells to produce a hypoglycemic effect.<\/jats:p>","DOI":"10.1038\/s41598-021-98714-1","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T11:04:18Z","timestamp":1635937458000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hypoglycemic mechanism of intestinal bypass surgery in type 2 diabetic rats"],"prefix":"10.1038","volume":"11","author":[{"given":"Siqi","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MingChang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ShanGeng","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"98714_CR1","doi-asserted-by":"publisher","unstructured":"Association AD. 6. Obesity management for the treatment of type 2 diabetes. Diabetes Care 39, S47. https:\/\/doi.org\/10.2337\/dc16-S009 (2016).","DOI":"10.2337\/dc16-S009"},{"key":"98714_CR2","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1007\/s11695-016-2320-z","volume":"11","author":"S Weng","year":"2016","unstructured":"Weng, S. et al. Influence of new modified biliopancreatic diversion on blood glucose in GK rats for a long period. World Chin. J. Digestol. 11, 1658\u20131663. https:\/\/doi.org\/10.1007\/s11695-016-2320-z (2016).","journal-title":"World Chin. J. Digestol."},{"key":"98714_CR3","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1007\/s11695-017-2599-4","volume":"27","author":"SG Weng","year":"2017","unstructured":"Weng, S. G. et al. Effects of duodenal-jejunal exclusion and new bilio-pancreatic diversion on blood glucose in rats with type 2 diabetes mellitus. Obes. Surg. 27, 2067\u20132072. https:\/\/doi.org\/10.1007\/s11695-017-2599-4 (2017).","journal-title":"Obes. Surg."},{"key":"98714_CR4","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/s11695-016-2320-z","volume":"27","author":"S Weng","year":"2017","unstructured":"Weng, S. et al. Influence of new modified biliopancreatic diversion on blood glucose and lipids in GK rats. Obes. Surg. 27, 657\u2013664. https:\/\/doi.org\/10.1007\/s11695-016-2320-z (2017).","journal-title":"Obes. Surg."},{"key":"98714_CR5","doi-asserted-by":"publisher","first-page":"2664","DOI":"10.1194\/jlr.M700330-JLR200","volume":"48","author":"I Kim","year":"2007","unstructured":"Kim, I. et al. Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J. Lip. Res. 48, 2664\u20132672. https:\/\/doi.org\/10.1194\/jlr.M700330-JLR200 (2007).","journal-title":"J. Lip. 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