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Sixty-six female and 43 male participants aged 44\u201367 were recruited. On radiography, joint-space narrowing, osteophytes and Kellgren\u2013Lawrence (KL) grade were evaluated. Based on radiography, 54 subjects (the study group) were diagnosed with radiographic OA (KL-grade \u2265\u20092) while the remaining 55 subjects (KL-grade &lt;\u20092) formed the control group. AE and KI were recorded with a custom-made prototype and compared with radiographic findings using area-under-curve (AUC) and independent T-test. Predictive logistic regression models were constructed using leave-one-out cross validation. In females, the parameters reflecting consistency of the AE patterns during specific tasks, KI, BMI and age had a significant statistical difference between the OA and control groups (p\u2009=\u20090.001\u20130.036). The selected AE signals, KI, age and BMI were used to construct a predictive model for radiographic OA with AUC of 90.3% (95% CI 83.5\u201397.2%) which showed a statistical improvement of the reference model based on age and BMI, with AUC of 84.2% (95% CI 74.8\u201393.6%). In males, the predictive model failed to improve the reference model. AE and KI provide complementary information to detect radiographic knee OA in females.<\/jats:p>","DOI":"10.1038\/s41598-021-98945-2","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T11:02:54Z","timestamp":1633086174000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Acoustic emissions and kinematic instability of the osteoarthritic knee joint: comparison with radiographic findings"],"prefix":"10.1038","volume":"11","author":[{"given":"Mika T.","family":"Nevalainen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Veikkola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Thevenot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksei","family":"Tiulpin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka","family":"Hirvasniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko","family":"Niinim\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simo S.","family":"Saarakkala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"key":"98945_CR1","doi-asserted-by":"publisher","first-page":"9332","DOI":"10.1073\/pnas.1703856114","volume":"114","author":"IJ Wallace","year":"2017","unstructured":"Wallace, I. 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AT: shareholder of Inmodi Oy and Ailean Technologies Oy. All the other authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19558"}}