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An augmented acute ventilatory response to hypoxia, being a marker of PCh oversensitivity, was also\u00a0identified as a marker of poor prognosis in HF. However, not much is known about the tonic (chronic) influence of PCh on cardio-respiratory parameters.\u00a0In our study\u00a030 HF patients and 30 healthy individuals were exposed to 100% oxygen for 1\u00a0min during which minute ventilation and hemodynamic parameters were non-invasively recorded. Systemic vascular resistance (SVR) and mean arterial pressure (MAP) responses to acute hyperoxia differed substantially between HF and control. In HF hyperoxia caused a significant drop in SVR in early stages with subsequent normalization, while increase in SVR was observed in controls. MAP increased in controls, but remained unchanged in HF. Bilateral carotid bodies excision performed in two HF subjects changed the response to hyperoxia towards the course seen in healthy individuals. These differences may be explained by the domination of early vascular reaction to hyperoxia in HF by vasodilation due to the inhibition of augmented tonic activity of PCh.\u00a0Otherwise, in healthy subjects the vasoconstrictive action of oxygen remains unopposed. The magnitude of SVR change during acute hyperoxia may be used as a novel method for tonic PCh activity assessment.<\/jats:p>","DOI":"10.1038\/s41598-021-99159-2","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T10:04:42Z","timestamp":1634810682000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Acute hyperoxia reveals tonic influence of peripheral chemoreceptors on systemic vascular resistance in heart failure patients"],"prefix":"10.1038","volume":"11","author":[{"given":"Stanislaw","family":"Tubek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Niewinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartlomiej","family":"Paleczny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Langner-Hetmanczuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldemar","family":"Banasiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"99159_CR1","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1093\/eurheartj\/ehv087","volume":"36","author":"JS Floras","year":"2015","unstructured":"Floras, J. 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PN has received research support from Coridea and Cibiem. BP none declared. AL none declared. WB none declared. PP has received research support from Coridea and Cibiem and served as a consultant to Cibiem.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20823"}}