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Skeels seeds have been shown to have diverse beneficial medical value due to their unique active components. This study analysed the composition of essential oils (EOs) of <jats:italic>C. lansium<\/jats:italic> seeds and investigated their potential antifungal effects against <jats:italic>Candida<\/jats:italic> strains<jats:italic>.<\/jats:italic> A total of forty-six components were identified in all samples by gas chromatography-mass spectrometry (GC\u2013MS). The main components were sabinene, <jats:italic>\u03b2<\/jats:italic>-phellandrene and 4-terpineol. Thirteen EOs of <jats:italic>C. lansium<\/jats:italic> seeds were classified into three clusters based on their components. Cluster analysis showed that the difference between the tropics and subtropics was the greatest. These EOs and the three main chemicals showed different antifungal activities against five <jats:italic>Candida<\/jats:italic> species (<jats:italic>C. albicans<\/jats:italic>, <jats:italic>C. tropicalis<\/jats:italic>, <jats:italic>C. glabrata<\/jats:italic>, <jats:italic>C. krusei<\/jats:italic> and <jats:italic>C. parapsilosis<\/jats:italic>). The antifungal activity against <jats:italic>C. glabrata<\/jats:italic> and <jats:italic>C. krusei<\/jats:italic> was higher than that against other <jats:italic>Candida<\/jats:italic> strains. EOs of <jats:italic>C. lansium<\/jats:italic> seeds displayed noteworthy antifungal activity against both sensitive and fluconazole-resistant strains, with inhibition zone diameters in the range of 9.4\u201323.4\u00a0mm. Comprehensive analysis illustrated the importance of sabinene, <jats:italic>\u03b2<\/jats:italic>-phellandrene and 4-terpineol to antifungal activity, and there may be some synergistic effects with other components. These results represent the first report about the correlation between the chemical composition of EOs of <jats:italic>C. lansium<\/jats:italic> seeds and antifungal activity. Taken together, the results obtained provide scientific evidence for the traditional use of <jats:italic>C. lansium<\/jats:italic> seeds waste.<\/jats:p>","DOI":"10.1038\/s41598-021-99188-x","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T17:14:08Z","timestamp":1633367648000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The influence of the chemical composition of essential oils of Clausena lansium seeds on the growth of Candida strains"],"prefix":"10.1038","volume":"11","author":[{"given":"Yinzheng","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanxiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huixin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowen","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"99188_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.05.016","author":"L Olivier-Gougenheim","year":"2021","unstructured":"Olivier-Gougenheim, L. et al. 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