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A total of 505 CBCT scans were evaluated, including a total of 2790 maxillary anterior teeth. The patients\u2019 demographic data, including age and sex, were recorded. The presence of DI and the related characteristics including bilateral occurrence; DI type according to Oehlers classification; and presence of periapical radiolucency, open apex, and\/or nearby impacted teeth were analyzed. The associations between DI and the other factors were analyzed using the chi-square and fisher exact tests. DI was detected in 7.3% of the patients and 1.6% of the teeth examined. Most of the DI-affected teeth were maxillary lateral incisors (76.1%), followed by mesiodens (19.6%) and maxillary central incisors (4.3%), while no DI was observed in the maxillary canines. Bilateral DI was found in 24.3% of the affected patients. Oehlers type I DI was the most frequent (80%). Periapical radiolucencies, open apices, and nearby impacted teeth were observed in 10.9%, 4.3%, and 30% of the invaginated teeth, respectively. DI was significantly associated with tooth type (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) but not with sex (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Although most of the DI cases are limited to the crown, CBCT imaging is essential for DI evaluation and management.<\/jats:p>","DOI":"10.1038\/s41598-021-99258-0","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T13:52:53Z","timestamp":1633441973000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Assessment of dens invaginatus and its characteristics in maxillary anterior teeth using cone-beam computed tomography"],"prefix":"10.1038","volume":"11","author":[{"given":"Manal","family":"Alkadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahaf","family":"Almohareb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soad","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Mehanny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raed","family":"Alsadhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"99258_CR1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1365-2591.1997.tb00679.x","volume":"30","author":"M H\u00fclsmann","year":"1997","unstructured":"H\u00fclsmann, M. 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