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Indeed, the strongest predictor of cardiovascular risk comes from night measurements. The aim of this study was to demonstrate that a wearable device (the Aktiia Bracelet) can accurately estimate BP in the most common body positions of daily life and thus become a candidate solution for the BP phenotyping of patients. We recruited 91 patients with BP ranging from low to hypertensive levels and compared BP values from the Aktiia Bracelet against auscultatory reference values for 4\u00a0weeks according to an extended ISO 81060-2 protocol. After initializing\u00a0on day one,\u00a0the observed means and standard deviations of differences for systolic BP were of 0.46\u2009\u00b1\u20097.75\u00a0mmHg in the sitting position,\u2009\u2212\u20092.44\u2009\u00b1\u200910.15\u00a0mmHg in the lying,\u2009\u2212\u20093.02\u2009\u00b1\u20096.10\u00a0mmHg in the sitting with the device on the lap, and\u2009\u2212\u20090.62\u2009\u00b1\u200912.51\u00a0mmHg in the standing position. Differences for diastolic BP readings were respectively of 0.39\u2009\u00b1\u20096.86\u00a0mmHg,\u2009\u2212\u20091.93\u2009\u00b1\u20097.65\u00a0mmHg,\u2009\u2212\u20094.22\u2009\u00b1\u20096.56\u00a0mmHg and\u2009\u2212\u20094.85\u2009\u00b1\u20099.11\u00a0mmHg. This study demonstrates that a wearable device can accurately estimate BP in the most common body positions compared to auscultation, although precision varies across positions. While wearable persistent BP monitors have the potential to facilitate the identification of individual BP phenotypes at scale, their prognostic value for cardiovascular events and its association with target organ damage will need cross-sectional and longitudinal studies. Deploying this technology at a community level may be also useful to drive public health interventions against the epidemy of hypertension.<\/jats:p>","DOI":"10.1038\/s41598-021-99294-w","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T10:04:50Z","timestamp":1634637890000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Validation of the optical Aktiia bracelet in different body positions for the persistent monitoring of blood pressure"],"prefix":"10.1038","volume":"11","author":[{"given":"Josep","family":"Sola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Vybornova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibylle","family":"Fallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erietta","family":"Polychronopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene","family":"Wurzner-Ghajarzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregoire","family":"Wuerzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"issue":"6","key":"99294_CR1","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1161\/HYPERTENSIONAHA.120.15026","volume":"75","author":"T Unger","year":"2020","unstructured":"Unger, T. et al. 2020 International Society of Hypertension global hypertension practice guidelines. 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G.W. serves as a consultant for Aktiia SA. All other authors report no potential conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20644"}}