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The presumed pathogenesis of idiopathic SSNHL includes circulatory disorders (e.g., cochlear infarction). We tested the hypothesis that patients with SSNHL who are at high stroke risk will have a lower rate of VS compared to those with low stroke risk. The rationale is that the primary cause of SSNHL in patients with high stroke risk might be a circulatory disturbance. We conducted a retrospective study in six hospitals. Our sampling of SSNHL patients included those diagnosed with idiopathic SSNHL and VS-associated SSNHL. SSNHL patients who had a head MRI were stratified by severity of hearing loss and evaluated for differences in the detection rate of VS between the high-scoring CHADS<jats:sub>2<\/jats:sub> (CHADS<jats:sub>2<\/jats:sub>-H-), an index of stroke risk, and low-scoring CHADS<jats:sub>2<\/jats:sub> (CHADS<jats:sub>2<\/jats:sub>-L-) groups. We identified 916 patients who met the inclusion criteria. For severe hearing loss, the CHADS<jats:sub>2<\/jats:sub>-H group had a significantly lower rate of VS than the CHADS<jats:sub>2<\/jats:sub>-L group (OR 0 [95% CI 0.00\u20130.612]; <jats:italic>P<\/jats:italic>\u2009=\u20090.007). These results indirectly support the hypothesis that a primary cause of severe idiopathic SSNHL in those at high risk of stroke might be a circulatory disorder.<\/jats:p>","DOI":"10.1038\/s41598-021-99731-w","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T13:24:52Z","timestamp":1634045092000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Severe sudden sensorineural hearing loss related to risk of stroke and atherosclerosis"],"prefix":"10.1038","volume":"11","author":[{"given":"Nobuyoshi","family":"Tsuzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Wasano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Oishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Hentona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Shimanuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Hiraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichi","family":"Shinden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"99731_CR1","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1097\/MAO.0000000000000222","volume":"34","author":"TH Alexander","year":"2013","unstructured":"Alexander, T. 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