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In this study, we employed an integrative approach to reveal the landscape of the human immune responses to<jats:italic>Candida<\/jats:italic>spp<jats:italic>.<\/jats:italic>through meta-analysis of microarray, bulk, and single-cell RNA sequencing (scRNA-seq) data for the blood transcriptome. We identified across these different studies a consistent interconnected network interplay of signaling molecules involved in both Toll-like receptor (TLR) and interferon (IFN) signaling cascades that is activated in response to different<jats:italic>Candida<\/jats:italic>species (<jats:italic>C. albicans<\/jats:italic>,<jats:italic>C. auris<\/jats:italic>,<jats:italic>C. glabrata<\/jats:italic>,<jats:italic>C. parapsilosis<\/jats:italic>, and<jats:italic>C. tropicalis<\/jats:italic>). Among these molecules are several types I IFN, indicating an overlap with antiviral immune responses. scRNA-seq data confirmed that genes commonly identified by the three transcriptomic methods show cell type-specific expression patterns in various innate and adaptive immune cells. These findings shed new light on the anti-<jats:italic>Candida<\/jats:italic>immune response, providing putative molecular pathways for therapeutic intervention.<\/jats:p>","DOI":"10.1038\/s41598-021-99838-0","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T17:43:34Z","timestamp":1634147014000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The network interplay of interferon and Toll-like receptor signaling pathways in the anti-Candida immune response"],"prefix":"10.1038","volume":"11","author":[{"given":"Ranieri Coelho","family":"Salgado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennyson Leandro M.","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre H. 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