{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:19:38Z","timestamp":1754396378825},"reference-count":163,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The roles of endothelial nitric oxide synthase (eNOS) in the ventilatory responses during and after a hypercapnic gas challenge (HCC, 5% CO<jats:sub>2<\/jats:sub>, 21% O<jats:sub>2<\/jats:sub>, 74% N<jats:sub>2<\/jats:sub>) were assessed in freely-moving female and male wild-type (WT) C57BL6 mice and eNOS knock-out (eNOS-\/-) mice of C57BL6 background using whole body plethysmography. HCC elicited an array of ventilatory responses that were similar in male and female WT mice, such as increases in breathing frequency (with falls in inspiratory and expiratory times), and increases in tidal volume, minute ventilation, peak inspiratory and expiratory flows, and inspiratory and expiratory drives. eNOS-\/- male mice had smaller increases in minute ventilation, peak inspiratory flow and inspiratory drive, and smaller decreases in inspiratory time than WT males. Ventilatory responses in female eNOS-\/- mice were similar to those in female WT mice. The ventilatory excitatory phase upon return to room-air was similar in both male and female WT mice. However, the post-HCC increases in frequency of breathing (with\u00a0decreases in inspiratory times), and increases in tidal volume, minute ventilation, inspiratory drive (i.e., tidal volume\/inspiratory time) and expiratory drive (i.e., tidal volume\/expiratory time), and peak inspiratory and expiratory flows in male eNOS-\/- mice were smaller than in male WT mice. In contrast, the post-HCC responses in female eNOS-\/- mice were equal to those of the female WT mice. These findings provide the first evidence that the loss of eNOS affects the ventilatory responses during and after HCC in male C57BL6 mice, whereas female C57BL6 mice can compensate for the loss of eNOS, at least in respect to triggering ventilatory responses to HCC.\n<\/jats:p>","DOI":"10.1038\/s41598-021-99922-5","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T19:27:17Z","timestamp":1634585237000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ventilatory responses during and following hypercapnic gas challenge are impaired in male but not female endothelial NOS knock-out mice"],"prefix":"10.1038","volume":"11","author":[{"given":"Paulina M.","family":"Getsy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sripriya","family":"Sundararajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter J.","family":"May","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham C.","family":"von Schill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dylan K.","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa A.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"key":"99922_CR1","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1002\/cphy.c140040","volume":"6","author":"RJ Wilson","year":"2016","unstructured":"Wilson, R. J. & Teppema, L. J. Integration of central and peripheral respiratory chemoreflexes. Compr. Physiol. 6, 1005\u20131041 (2016).","journal-title":"Compr. Physiol."},{"key":"99922_CR2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1242\/jeb.100.1.23","volume":"100","author":"RG O'Regan","year":"1982","unstructured":"O\u2019Regan, R. G. & Majcherczyk, S. Role of peripheral chemoreceptors and central chemosensitivity in the regulation of respiration and circulation. J. Exp. Biol. 100, 23\u201340 (1982).","journal-title":"J. Exp. Biol."},{"issue":"108","key":"99922_CR3","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1152\/japplphysiol.01059.2009","volume":"1985","author":"HV Forster","year":"2010","unstructured":"Forster, H. V. & Smith, C. A. Contributions of central and peripheral chemoreceptors to the ventilatory response to CO2\/H+. J. Appl. Physiol. 1985(108), 989\u2013994 (2010).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR4","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.pbiomolbio.2005.07.001","volume":"91","author":"S Lahiri","year":"2006","unstructured":"Lahiri, S. et al. Oxygen sensing in the body. Prog. Biophys. Mol. Biol. 91, 249\u2013286 (2006).","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"99922_CR5","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1016\/S1357-2725(03)00050-5","volume":"35","author":"S Lahiri","year":"2003","unstructured":"Lahiri, S. & Forster, R. E. 2nd. CO2\/H+ sensing: Peripheral and central chemoreception. Int. J. Biochem. Cell. Biol. 35, 1413\u20131435 (2003).","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"99922_CR6","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.wneu.2019.04.064","volume":"127","author":"S Kikuta","year":"2019","unstructured":"Kikuta, S., Iwanaga, J., Kusukawa, J. & Tubbs, R. S. Carotid sinus nerve: A comprehensive review of its anatomy, variations, pathology, and clinical applications. World Neurosurg. 127, 370\u2013374 (2019).","journal-title":"World Neurosurg."},{"key":"99922_CR7","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1152\/physrev.00012.2009","volume":"90","author":"LJ Teppema","year":"2010","unstructured":"Teppema, L. J. & Dahan, A. The ventilatory response to hypoxia in mammals: Mechanisms, measurement, and analysis. Physiol. Rev. 90, 675\u2013754 (2010).","journal-title":"Physiol. Rev."},{"key":"99922_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00238411","volume":"144","author":"C Peers","year":"1995","unstructured":"Peers, C. & Buckler, K. J. Transduction of chemostimuli by the type I carotid body cell. J. Memb. Biol. 144, 1\u20139 (1995).","journal-title":"J. Memb. Biol."},{"key":"99922_CR9","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1139\/y2012-054","volume":"90","author":"A Tse","year":"2012","unstructured":"Tse, A., Yan, L., Lee, A. K. & Tse, F. W. Autocrine and paracrine actions of ATP in rat carotid body. Can. J. Physiol. Pharmacol. 90, 705\u2013711 (2012).","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"99922_CR10","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1152\/jappl.1984.57.4.931","volume":"57","author":"C Eyzaguirre","year":"1984","unstructured":"Eyzaguirre, C. & Zapata, P. Perspectives in carotid body research. J. Appl. Physiol. 57, 931\u2013957 (1984).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR11","doi-asserted-by":"publisher","first-page":"22872295","DOI":"10.1152\/jappl.2000.88.6.2287","volume":"88","author":"NR Prabhakar","year":"2000","unstructured":"Prabhakar, N. R. Oxygen sensing by the carotid body chemoreceptors. J. Appl. Physiol. 88, 22872295 (2000).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR12","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1152\/physrev.1994.74.4.829","volume":"74","author":"C Gonzalez","year":"1994","unstructured":"Gonzalez, C., Almaraz, L., Obeso, A. & Rigual, R. Carotid body chemoreceptors: From natural stimuli to sensory discharges. Physiol. Rev. 74, 829\u2013898 (1994).","journal-title":"Physiol. Rev."},{"key":"99922_CR13","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1002\/cphy.c100069","volume":"2","author":"P Kumar","year":"2012","unstructured":"Kumar, P. & Prabhakar, N. R. Peripheral chemoreceptors: Function and plasticity of the carotid body. Compr. Physiol. 2, 141\u2013219 (2012).","journal-title":"Compr. Physiol."},{"key":"99922_CR14","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3389\/fphys.2018.00225","volume":"9","author":"EM Leonard","year":"2018","unstructured":"Leonard, E. M., Salman, S. & Nurse, C. A. Sensory processing and integration at the carotid body tripartite synapse: Neurotransmitter functions and effects of chronic hypoxia. Front. Physiol. 9, 225 (2018).","journal-title":"Front. Physiol."},{"key":"99922_CR15","doi-asserted-by":"publisher","first-page":"341","DOI":"10.4067\/S0716-97602005000400005","volume":"38","author":"C Eyzaguirre","year":"2005","unstructured":"Eyzaguirre, C. Chemical and electric transmission in the carotid body chemoreceptor complex. Biol. Res. 38, 341\u2013345 (2005).","journal-title":"Biol. Res."},{"key":"99922_CR16","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1113\/expphysiol.2005.031922","volume":"91","author":"NR Prabhakar","year":"2006","unstructured":"Prabhakar, N. R. O2 sensing at the mammalian carotid body: Why multiple O2 sensors and multiple transmitters?. Exp. Physiol. 91, 17\u201323 (2006).","journal-title":"Exp. Physiol."},{"key":"99922_CR17","doi-asserted-by":"publisher","first-page":"913","DOI":"10.3389\/fphar.2017.00913","volume":"8","author":"SV Conde","year":"2017","unstructured":"Conde, S. V., Monteiro, E. C. & Sacramento, J. F. Purines and carotid body: New roles in pathological conditions. Front. Pharmacol. 8, 913 (2017).","journal-title":"Front. Pharmacol."},{"key":"99922_CR18","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.brainresrev.2004.05.007","volume":"47","author":"R Iturriaga","year":"2004","unstructured":"Iturriaga, R. & Alcayaga, J. Neurotransmission in the carotid body: Transmitters and modulators between glomus cells and petrosal ganglion nerve terminals. Brain Res. Brain Res. Rev. 47, 46\u201353 (2004).","journal-title":"Brain Res. Brain Res. Rev."},{"key":"99922_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.autneu.2005.04.008","volume":"120","author":"CA Nurse","year":"2005","unstructured":"Nurse, C. A. Neurotransmission and neuromodulation in the chemosensory carotid body. Auton. Neurosci. 120, 1\u20139 (2005).","journal-title":"Auton. Neurosci."},{"key":"99922_CR20","doi-asserted-by":"crossref","unstructured":"Prabhakar, N.R., Peng, Y.J. & Nanduri, J. Recent advances in understanding the physiology of hypoxic sensing by the carotid body. F1000Res. 7, pii, F1000 Faculty Rev-1900. (2018).","DOI":"10.12688\/f1000research.16247.1"},{"key":"99922_CR21","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00441-018-2807-0","volume":"372","author":"NR Prabhakar","year":"2018","unstructured":"Prabhakar, N. R., Peng, Y. J., Yuan, G. & Nanduri, J. Reactive oxygen radicals and gaseous transmitters in carotid body activation by intermittent hypoxia. Cell Tissue Res. 372, 427\u2013431 (2018).","journal-title":"Cell Tissue Res."},{"key":"99922_CR22","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4067\/S0716-97602001000200019","volume":"34","author":"R Iturriaga","year":"2001","unstructured":"Iturriaga, R. Nitric oxide and carotid body chemoreception. Biol. Res. 34, 135\u2013139 (2001).","journal-title":"Biol. Res."},{"key":"99922_CR23","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.semcdb.2012.09.006","volume":"24","author":"CA Nurse","year":"2013","unstructured":"Nurse, C. A. & Piskuric, N. A. Signal processing at mammalian carotid body chemoreceptors. Semin. Cell Dev. Biol. 24, 22\u201330 (2013).","journal-title":"Semin. Cell Dev. Biol."},{"key":"99922_CR24","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.resp.2005.04.017","volume":"149","author":"A Bairam","year":"2005","unstructured":"Bairam, A. & Carroll, J. L. Neurotransmitters in carotid body development. Respir. Physiol. Neurobiol. 149, 217\u2013232 (2005).","journal-title":"Respir. Physiol. Neurobiol."},{"key":"99922_CR25","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1113\/expphysiol.2009.049312","volume":"95","author":"CA Nurse","year":"2010","unstructured":"Nurse, C. A. Neurotransmitter and neuromodulatory mechanisms at peripheral arterial chemoreceptors. Exp. Physiol. 95, 657\u2013667 (2010).","journal-title":"Exp. Physiol."},{"key":"99922_CR26","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1113\/jphysiol.2003.052415","volume":"553","author":"HJ Timmers","year":"2003","unstructured":"Timmers, H. J., Wieling, W., Karemaker, J. M. & Lenders, J. W. Denervation of carotid baro- and chemoreceptors in humans. J. Physiol. 553, 3\u201311 (2003).","journal-title":"J. Physiol."},{"key":"99922_CR27","first-page":"843","volume":"46","author":"JW Bellville","year":"1979","unstructured":"Bellville, J. W. et al. Central and peripheral chemoreflex loop gain in normal and carotid body-resected subjects. J. Appl. Physiol. Respir. Environ. Exerc. Physiol. 46, 843\u2013853 (1979).","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"key":"99922_CR28","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1113\/jphysiol.2003.042259","volume":"549","author":"M Fatemian","year":"2003","unstructured":"Fatemian, M. et al. The respiratory response to carbon dioxide in humans with unilateral and bilateral resections of the carotid bodies. J. Physiol. 549, 965\u2013973 (2003).","journal-title":"J. Physiol."},{"key":"99922_CR29","doi-asserted-by":"publisher","first-page":"e239","DOI":"10.1371\/journal.pmed.0040239","volume":"4","author":"A Dahan","year":"2007","unstructured":"Dahan, A., Nieuwenhuijs, D. & Teppema, L. Plasticity of central chemoreceptors: Effect of bilateral carotid body resection on central CO2 sensitivity. PLoS Med. 4, e239 (2007).","journal-title":"PLoS Med."},{"key":"99922_CR30","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1056\/NEJM197111112852002","volume":"285","author":"R Lugliani","year":"1971","unstructured":"Lugliani, R., Whipp, B. J., Seard, C. & Wasserman, K. Effect of bilateral carotid-body resection on ventilatory control at rest and during exercise in man. N. Engl. J. Med. 285, 1105\u20131111 (1971).","journal-title":"N. Engl. J. Med."},{"key":"99922_CR31","doi-asserted-by":"publisher","first-page":"917","DOI":"10.2170\/jjphysiol.38.917","volume":"38","author":"Y Honda","year":"1988","unstructured":"Honda, Y., Hashizume, I., Kimura, H. & Severinghuas, J. W. Bilateral carotid body resection in man enhances hypoxic tachycardia. Jpn. J. Physiol. 38, 917\u2013928 (1988).","journal-title":"Jpn. J. Physiol."},{"key":"99922_CR32","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/978-1-4615-2966-8_50","volume":"337","author":"Y Honda","year":"1993","unstructured":"Honda, Y. & Tanaka, M. Respiratory and cardiovascular activities in carotid body resected humans. Adv. Exp. Med. Biol. 337, 359\u2013364 (1993).","journal-title":"Adv. Exp. Med. Biol."},{"key":"99922_CR33","first-page":"871","volume":"45","author":"GD Swanson","year":"1978","unstructured":"Swanson, G. D. et al. Effect of hypercapnia on hypoxic ventilatory drive in carotid body-resected man. J. Appl. Physiol. Respir. Environ. Exerc. Physiol. 45, 871\u2013877 (1978).","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"key":"99922_CR34","doi-asserted-by":"publisher","first-page":"535","DOI":"10.2170\/jjphysiol.35.535","volume":"35","author":"Y Honda","year":"1985","unstructured":"Honda, Y. Role of carotid chemoreceptors in control of breathing at rest and in exercise: Studies on human subjects with bilateral carotid body resection. Jpn. J. Physiol. 35, 535\u2013544 (1985).","journal-title":"Jpn. J. Physiol."},{"key":"99922_CR35","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1113\/jphysiol.2005.093328","volume":"568","author":"J Soliz","year":"2005","unstructured":"Soliz, J. et al. Erythropoietin regulates hypoxic ventilation in mice by interacting with brainstem and carotid bodies. J. Physiol. 568, 559\u2013571 (2005).","journal-title":"J. Physiol."},{"key":"99922_CR36","doi-asserted-by":"publisher","first-page":"R1511","DOI":"10.1152\/ajpregu.00205.2010","volume":"299","author":"M Gassmann","year":"2010","unstructured":"Gassmann, M., Pfistner, C., Doan, V. D., Vogel, J. & Soliz, J. Impaired ventilatory acclimatization to hypoxia in female mice overexpressing erythropoietin: Unexpected deleterious effect of estradiol in carotid bodies. Am. J. Physiol. Regul. Integr. Comp. Physiol. 299, R1511\u2013R1520 (2010).","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"116","key":"99922_CR37","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1152\/japplphysiol.01050.2013","volume":"1985","author":"B Gaston","year":"2014","unstructured":"Gaston, B. et al. Essential role of hemoglobin beta-93-cysteine in post-hypoxia facilitation of breathing in conscious mice. J. Appl. Physiol. 1985(116), 1290\u20131299 (2014).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR38","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1469-445X.1999.tb00071.x","volume":"84","author":"M Kongo","year":"1999","unstructured":"Kongo, M., Yamamoto, R., Kobayashi, M. & Nosaka, S. Hypoxia inhibits baroreflex vagal bradycardia via a central action in anaesthetized rats. Exp. Physiol. 84, 47\u201356 (1999).","journal-title":"Exp. Physiol."},{"key":"99922_CR39","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1097\/ALN.0000000000000844","volume":"123","author":"FJ Golder","year":"2005","unstructured":"Golder, F. J. et al. Identification and characterization of GAL-021 as a novel breathing control modulator. Anesthesiology 123, 1093\u20131104 (2005).","journal-title":"Anesthesiology"},{"key":"99922_CR40","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/BF00615516","volume":"396","author":"F Hayashi","year":"1983","unstructured":"Hayashi, F., Yoshida, A., Fukuda, Y. & Honda, Y. The ventilatory response to hypoxia in the anesthetized rat. Pflugers Arch. 396, 121\u2013127 (1983).","journal-title":"Pflugers Arch."},{"issue":"101","key":"99922_CR41","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1152\/japplphysiol.00100.2006","volume":"1985","author":"FJ Jacono","year":"2006","unstructured":"Jacono, F. J. et al. Acute lung injury augments hypoxic ventilatory response in the absence of systemic hypoxemia. J. Appl. Physiol. 1985(101), 1795\u20131802 (2006).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR42","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/0014-4886(83)90287-X","volume":"80","author":"AT Ryan","year":"1983","unstructured":"Ryan, A. T., Ward, D. A. & Megirian, D. Sleep-waking patterns of intact and carotid sinus nerve-transected rats during hypoxic-CO2 breathing. Exp. Neurol. 80, 337\u2013348 (1983).","journal-title":"Exp. Neurol."},{"key":"99922_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/sleep\/5.1.1","volume":"5","author":"AT Ryan","year":"1982","unstructured":"Ryan, A. T. & Megirian, D. Sleep-wake patterns of intact and carotid sinus nerve sectioned rats during hypoxia. Sleep 5, 1\u201310 (1982).","journal-title":"Sleep"},{"key":"99922_CR44","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ejphar.2018.07.018","volume":"834","author":"SM Baby","year":"2018","unstructured":"Baby, S. M. et al. Bilateral carotid sinus nerve transection exacerbates morphine-induced respiratory depression. Eur. J. Pharmacol. 834, 17\u201329 (2018).","journal-title":"Eur. J. Pharmacol."},{"key":"99922_CR45","first-page":"344","volume":"42","author":"HN Sapru","year":"1977","unstructured":"Sapru, H. N. & Krieger, A. J. Carotid and aortic chemoreceptor function in the rat. J. Appl. Physiol. Respir. Environ. Exerc. Physiol. 42, 344\u2013348 (1977).","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"key":"99922_CR46","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/0034-5687(84)90096-3","volume":"57","author":"SR Chiocchio","year":"1984","unstructured":"Chiocchio, S. R., Hilton, S. M., Tramezzani, J. H. & Willshaw, P. Loss of peripheral chemoreflexes to hypoxia after carotid body removal in the rat. Respir. Physiol. 57, 235\u2013246 (1984).","journal-title":"Respir. Physiol."},{"key":"99922_CR47","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1111\/j.1469-7793.2000.t01-4-00493.x","volume":"522","author":"JC Roux","year":"2000","unstructured":"Roux, J. C., Peyronnet, J., Pascual, O., Dalmaz, Y. & Pequignot, J. M. Ventilatory and central neurochemical reorganisation of O2 chemoreflex after carotid sinus nerve transection in rat. J. Physiol. 522, 493\u2013501 (2000).","journal-title":"J. Physiol."},{"key":"99922_CR48","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1113\/jphysiol.1985.sp015631","volume":"361","author":"RL Martin-Body","year":"1985","unstructured":"Martin-Body, R. L., Robson, G. J. & Sinclair, J. D. Respiratory effects of sectioning the carotid sinus glossopharyngeal and abdominal vagal nerves in the awake rat. J. Physiol. 361, 35\u201345 (1985).","journal-title":"J. Physiol."},{"key":"99922_CR49","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1113\/jphysiol.1986.sp016272","volume":"380","author":"RL Martin-Body","year":"1986","unstructured":"Martin-Body, R. L., Robson, G. J. & Sinclair, J. D. Restoration of hypoxic respiratory responses in the awake rat after carotid body denervation by sinus nerve section. J. Physiol. 380, 61\u201373 (1986).","journal-title":"J. Physiol."},{"key":"99922_CR50","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1113\/jphysiol.1988.sp017402","volume":"407","author":"RL Martin-Body","year":"1988","unstructured":"Martin-Body, R. L. Brain transections demonstrate the central origin of hypoxic ventilatory depression in carotid body-denervated rats. J. Physiol. 407, 41\u201352 (1988).","journal-title":"J. Physiol."},{"key":"99922_CR51","first-page":"L767","volume":"274","author":"JV Weil","year":"1998","unstructured":"Weil, J. V. et al. Strain-associated differences in hypoxic chemosensitivity of the carotid body in rats. Am. J. Physiol. 274, L767\u2013L774 (1998).","journal-title":"Am. J. Physiol."},{"issue":"97","key":"99922_CR52","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1152\/japplphysiol.00025.2004","volume":"1985","author":"M Izumizaki","year":"2004","unstructured":"Izumizaki, M., Pokorski, M. & Homma, I. Role of the carotid bodies in chemosensory ventilatory responses in the anesthetized mouse. J. Appl. Physiol. 1985(97), 1401\u20131407 (2004).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR53","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1113\/jphysiol.1990.sp018142","volume":"426","author":"MF Czyzyk-Krzeska","year":"1990","unstructured":"Czyzyk-Krzeska, M. F. & Trzebski, A. Respiratory-related discharge pattern of sympathetic nerve activity in the spontaneously hypertensive rat. J. Physiol. 426, 355\u2013368 (1990).","journal-title":"J. Physiol."},{"key":"99922_CR54","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1152\/jappl.2001.91.1.328","volume":"91","author":"JR Rodman","year":"2001","unstructured":"Rodman, J. R., Curran, A. K., Henderson, K. S., Dempsey, J. A. & Smith, C. A. Carotid body denervation in dogs: Eupnea and the ventilatory response to hyperoxic hypercapnia. J. Appl. Physiol. 91, 328\u2013335 (2001).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR55","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1113\/jphysiol.2010.187211","volume":"588","author":"GM Blain","year":"2010","unstructured":"Blain, G. M., Smith, C. A., Henderson, K. S. & Dempsey, J. A. Peripheral chemoreceptors determine the respiratory sensitivity of central chemoreceptors to CO2. J. Physiol. 588, 2455\u20132471 (2010).","journal-title":"J. Physiol."},{"key":"99922_CR56","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/0034-5687(73)90062-5","volume":"17","author":"P Bouverot","year":"1973","unstructured":"Bouverot, P., Candas, V. & Libert, J. P. Role of the arterial chemoreceptors in ventilatory adaptation to hypoxia of awake dogs and rabbits. Respir. Physiol. 17, 209\u2013219 (1973).","journal-title":"Respir. Physiol."},{"key":"99922_CR57","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/978-1-4615-2966-8_20","volume":"337","author":"RE Forster","year":"1993","unstructured":"Forster, R. E. 2nd Carbonic anhydrase and the carotid body. Adv. Exp. Med. Biol. 337, 137\u2013147 (1993).","journal-title":"Adv. Exp. Med. Biol."},{"key":"99922_CR58","first-page":"319","volume":"26","author":"R Iturriaga","year":"1993","unstructured":"Iturriaga, R. Carotid body chemoreception: The importance of CO2-HCO3- and carbonic anhydrase. Biol. Res. 26, 319\u2013329 (1993).","journal-title":"Biol. Res."},{"key":"99922_CR59","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0301-0082(99)00008-8","volume":"59","author":"E Nattie","year":"1999","unstructured":"Nattie, E. CO2, brainstem chemoreceptors and breathing. Prog. Neurobiol. 59, 299\u2013331 (1999).","journal-title":"Prog. Neurobiol."},{"issue":"105","key":"99922_CR60","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1152\/japplphysiol.90452.2008","volume":"1985","author":"PG Guyenet","year":"2008","unstructured":"Guyenet, P. G. The 2008 carl Ludwig lecture: Retrotrapezoid nucleus, CO2 homeostasis, and breathing automaticity. J. Appl. Physiol. 1985(105), 404\u2013416 (2008).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR61","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1113\/jphysiol.2008.150870","volume":"586","author":"PG Guyenet","year":"2008","unstructured":"Guyenet, P. G., Stornetta, R. L. & Bayliss, D. A. Retrotrapezoid nucleus and central chemoreception. J. Physiol. 586, 2043\u20132048 (2008).","journal-title":"J. Physiol."},{"key":"99922_CR62","doi-asserted-by":"publisher","first-page":"3883","DOI":"10.1002\/cne.22435","volume":"518","author":"PG Guyenet","year":"2010","unstructured":"Guyenet, P. G., Stornetta, R. L. & Bayliss, D. A. Central respiratory chemoreception. J. Comp. Neurol. 518, 3883\u20133906 (2010).","journal-title":"J. Comp. Neurol."},{"key":"99922_CR63","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/978-94-007-4584-1_16","volume":"758","author":"PG Guyenet","year":"2012","unstructured":"Guyenet, P. G., Stornetta, R. L., Abbott, S. B., Depuy, S. D. & Kanbar, R. The retrotrapezoid nucleus and breathing. Adv. Exp. Med. Biol. 758, 115\u2013122 (2012).","journal-title":"Adv. Exp. Med. Biol."},{"key":"99922_CR64","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/j.neuron.2015.08.001","volume":"87","author":"PG Guyenet","year":"2015","unstructured":"Guyenet, P. G. & Bayliss, D. A. Neural control of breathing and CO2 homeostasis. Neuron 87, 946\u2013961 (2015).","journal-title":"Neuron"},{"key":"99922_CR65","doi-asserted-by":"publisher","first-page":"C1493","DOI":"10.1152\/ajpcell.00282.2004","volume":"287","author":"RW Putnam","year":"2004","unstructured":"Putnam, R. W., Filosa, J. A. & Ritucci, N. A. Cellular mechanisms involved in CO2 and acid signaling in chemosensitive neurons. Am. J. Physiol. Cell Physiol. 287, C1493\u2013C1526 (2004).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"99922_CR66","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1152\/physrev.00003.2019","volume":"100","author":"EP Cummins","year":"2020","unstructured":"Cummins, E. P., Strowitzki, M. J. & Taylor, C. T. Mechanisms and consequences of oxygen and carbon dioxide sensing in mammals. Physiol. Rev. 100, 463\u2013488 (2020).","journal-title":"Physiol. Rev."},{"key":"99922_CR67","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1165\/rcmb.2013-0359OC","volume":"52","author":"LA Palmer","year":"2015","unstructured":"Palmer, L. A. et al. Hypoxia-induced changes in protein s-nitrosylation in female mouse brainstem. Am. J. Respir. Cell Mol. Biol. 52, 37\u201345 (2015).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"99922_CR68","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.resp.2012.11.010","volume":"185","author":"LA Palmer","year":"2013","unstructured":"Palmer, L. A. et al. Hypoxia-induced ventilatory responses in conscious mice: Gender differences in ventilatory roll-off and facilitation. Respir. Physiol. Neurobiol. 185, 497\u2013505 (2013).","journal-title":"Respir. Physiol. Neurobiol."},{"key":"99922_CR69","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.resp.2012.11.009","volume":"185","author":"LA Palmer","year":"2013","unstructured":"Palmer, L. A. et al. Ventilatory responses during and following exposure to a hypoxic challenge in conscious mice deficient or null in S-nitrosoglutathione reductase. Respir. Physiol. Neurobiol. 185, 571\u2013658 (2013).","journal-title":"Respir. Physiol. Neurobiol."},{"key":"99922_CR70","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/978-1-4939-7665-2_13","volume":"1742","author":"P Ortega-S\u00e1enz","year":"2018","unstructured":"Ortega-S\u00e1enz, P., Caballero, C., Gao, L. & L\u00f3pez-Barneo, J. Testing acute oxygen sensing in genetically modified mice: Plethysmography and amperometry. Methods Mol. Biol. 1742, 139\u2013153 (2018).","journal-title":"Methods Mol. Biol."},{"key":"99922_CR71","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/0-306-46825-5_55","volume":"475","author":"DD Kline","year":"2000","unstructured":"Kline, D. D. & Prabhakar, N. R. Peripheral chemosensitivity in mutant mice deficient in nitric oxide synthase. Adv. Exp. Med. Biol. 475, 571\u2013579 (2000).","journal-title":"Adv. Exp. Med. Biol."},{"key":"99922_CR72","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1523\/JNEUROSCI.4556-04.2005","volume":"25","author":"DD Kline","year":"2005","unstructured":"Kline, D. D. et al. Kv1.1 deletion augments the afferent hypoxic chemosensory pathway and respiration. J. Neurosci. 25, 3389\u20133399 (2005).","journal-title":"J. Neurosci."},{"key":"99922_CR73","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.resp.2014.09.006","volume":"204","author":"PM Getsy","year":"2014","unstructured":"Getsy, P. M. et al. Enhanced non-eupneic breathing following hypoxic, hypercapnic or hypoxic-hypercapnic gas challenges in conscious mice. Respir. Physiol. Neurobiol. 204, 147\u2013159 (2014).","journal-title":"Respir. Physiol. Neurobiol."},{"key":"99922_CR74","doi-asserted-by":"publisher","first-page":"e009236","DOI":"10.1161\/JAHA.118.009236","volume":"7","author":"Y Gao","year":"2018","unstructured":"Gao, Y., Stuart, D., Takahishi, T. & Kohan, D. E. Nephron-specific disruption of nitric oxide synthase 3 causes hypertension and impaired salt excretion. J. Am. Heart Assoc. 7, e009236 (2018).","journal-title":"J. Am. Heart Assoc."},{"key":"99922_CR75","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/978-3-319-91137-3_14","volume":"1071","author":"YJ Peng","year":"2018","unstructured":"Peng, Y. J., Zhang, X., Nanduri, J. & Prabhakar, N. R. Therapeutic targeting of the carotid body for treating sleep apnea in a pre-clinical mouse model. Adv. Exp. Med. Biol. 1071, 109\u2013114 (2018).","journal-title":"Adv. Exp. Med. Biol."},{"key":"99922_CR76","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1113\/jphysiol.2004.062281","volume":"557","author":"MT P\u00e9rez-Garc\u00eda","year":"2004","unstructured":"P\u00e9rez-Garc\u00eda, M. T., Colinas, O., Miguel-Velado, E., Moreno-Dom\u00ednguez, A. & L\u00f3pez-L\u00f3pez, J. R. Characterization of the Kv channels of mouse carotid body chemoreceptor cells and their role in oxygen sensing. J. Physiol. 557, 457\u2013471 (2004).","journal-title":"J. Physiol."},{"key":"99922_CR77","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/978-3-319-18440-1_37","volume":"860","author":"LE Pichard","year":"2015","unstructured":"Pichard, L. E. et al. Role of BK channels in murine carotid body neural responses in vivo. Adv. Exp. Med. Biol. 860, 325\u2013333 (2015).","journal-title":"Adv. Exp. Med. Biol."},{"key":"99922_CR78","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1007\/0-306-46825-5_69","volume":"475","author":"L He","year":"2000","unstructured":"He, L., Chen, J., Dinger, B. & Fidone, S. Characteristics of carotid body chemosensitivity in the mouse. Baseline studies for future experiments with knockout animals. Adv. Exp. Med. Biol. 475, 697\u2013704 (2000).","journal-title":"Adv. Exp. Med. Biol."},{"key":"99922_CR79","doi-asserted-by":"publisher","first-page":"C27","DOI":"10.1152\/ajpcell.2002.282.1.C27","volume":"282","author":"L He","year":"2002","unstructured":"He, L. et al. Characteristics of carotid body chemosensitivity in NADPH oxidase-deficient mice. Am. J. Physiol. Cell Physiol. 282, C27\u2013C33 (2002).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"99922_CR80","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-1-4419-9280-2_5","volume":"536","author":"L He","year":"2003","unstructured":"He, L. et al. Carotid body chemoreceptor activity in mice deficient in selected subunits of NADPH oxidase. Adv. Exp. Med. Biol. 536, 41\u201346 (2003).","journal-title":"Adv. Exp. Med. Biol."},{"key":"99922_CR81","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.resp.2017.08.009","volume":"246","author":"J Wang","year":"2017","unstructured":"Wang, J., Hogan, J. O., Wang, R., White, C. & Kim, D. Role of cystathionine-\u03b3-lyase in hypoxia-induced changes in TASK activity, intracellular [Ca2+] and ventilation in mice. Respir. Physiol. Neurobiol. 246, 98\u2013106 (2017).","journal-title":"Respir. Physiol. Neurobiol."},{"key":"99922_CR82","doi-asserted-by":"crossref","unstructured":"Eldridge, F.L. & Millhom, D.E. Oscillation, gating, and memory in the respiratory control system. In: The Respiratory System; Control of Breathing. Cherniack, N.S. & Widdicombe, J.G. (eds), American Physiological Society, Bethesda (1986).","DOI":"10.1002\/cphy.cp030203"},{"key":"99922_CR83","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0034-5687(98)00026-7","volume":"112","author":"FL Powell","year":"1998","unstructured":"Powell, F. L., Milsom, W. K. & Mitchell, G. S. Time domains of the hypoxic ventilatory response. Respir. Physiol. 112, 123\u2013134 (1998).","journal-title":"Respir. Physiol."},{"key":"99922_CR84","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/978-1-4615-1375-9_33","volume":"499","author":"DD Kline","year":"2001","unstructured":"Kline, D. D. & Prabhakar, N. R. Role of nitric oxide in short-term potentiation and long-term facilitation: Involvement of NO in breathing stability. Adv. Exp. Med. Biol. 499, 215\u2013219 (2001).","journal-title":"Adv. Exp. Med. Biol."},{"key":"99922_CR85","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1113\/jphysiol.2001.014571","volume":"539","author":"DD Kline","year":"2002","unstructured":"Kline, D. D., Overholt, J. L. & Prabhakar, N. R. Mutant mice deficient in NOS-1 exhibit attenuated long-term facilitation and short-term potentiation in breathing. J. Physiol. 539, 309\u2013315 (2002).","journal-title":"J. Physiol."},{"key":"99922_CR86","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1152\/japplphysiol.00904.2001","volume":"92","author":"CG Tankersley","year":"2002","unstructured":"Tankersley, C. G., Irizarry, R., Flanders, S. & Rabold, R. Circadian rhythm variation in activity, body temperature, and heart rate between C3H\/HeJ and C57BL\/6J inbred strains. J. Appl. Physiol. 92, 870\u2013877 (2002).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR87","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1152\/physiolgenomics.00197.2003","volume":"20","author":"MJ Campen","year":"2004","unstructured":"Campen, M. J. et al. Phenotypic variation in cardiovascular responses to acute hypoxic and hypercapnic exposure in mice. Physiol. Genom. 20, 15\u201320 (2004).","journal-title":"Physiol. Genom."},{"key":"99922_CR88","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1152\/japplphysiol.00039.2005","volume":"99","author":"MJ Campen","year":"2005","unstructured":"Campen, M. J., Tagaito, Y., Jenkins, T. P., Balbir, A. & O\u2019Donnell, C. P. Heart rate variability responses to hypoxic and hypercapnic exposures in different mouse strains. J. Appl. Physiol. 99, 807\u2013813 (2005).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR89","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3389\/fphys.2013.00355","volume":"4","author":"SG Tewari","year":"2013","unstructured":"Tewari, S. G. et al. Analysis of cardiovascular dynamics in pulmonary hypertensive C57BL6\/J mice. Front. Physiol. 4, 355 (2013).","journal-title":"Front. Physiol."},{"key":"99922_CR90","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.1152\/jappl.2001.91.6.2758","volume":"91","author":"Y Tagaito","year":"2001","unstructured":"Tagaito, Y. et al. A model of sleep-disordered breathing in the C57BL\/6J mouse. J. Appl. Physiol. 91, 2758\u20132766 (2001).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR91","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1152\/japplphysiol.00069.2008","volume":"105","author":"M Yamauchi","year":"2008","unstructured":"Yamauchi, M., Dostal, J., Kimura, H. & Strohl, K. P. Effects of buspirone on posthypoxic ventilatory behavior in the C57BL\/6J and A\/J mouse strains. J. Appl. Physiol. 105, 518\u2013526 (2008).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR92","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.resp.2008.05.003","volume":"162","author":"M Yamauchi","year":"2008","unstructured":"Yamauchi, M. et al. Post-sigh breathing behavior and spontaneous pauses in the C57BL\/6J (B6) mouse. Respir. Physiol. Neurobiol. 162, 117\u2013125 (2008).","journal-title":"Respir. Physiol. Neurobiol."},{"key":"99922_CR93","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/978-0-387-73693-8_13","volume":"605","author":"M Yamauchi","year":"2008","unstructured":"Yamauchi, M., Dostal, J. & Strohl, K. P. Post-hypoxic unstable breathing in the C57BL\/6J mouse: Effects of acetazolamide. Adv. Exper. Med. Biol. 605, 75\u201379 (2008).","journal-title":"Adv. Exper. Med. Biol."},{"key":"99922_CR94","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/978-1-4419-5692-7_62","volume":"669","author":"M Yamauchi","year":"2010","unstructured":"Yamauchi, M., Kimura, H. & Strohl, K. P. Mouse models of apnea: Strain differences in apnea expression and its pharmacologic and genetic modification. Adv. Exper. Med. Biol. 669, 303\u2013307 (2010).","journal-title":"Adv. Exper. Med. Biol."},{"key":"99922_CR95","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0034-5687(00)00132-8","volume":"121","author":"F Han","year":"2000","unstructured":"Han, F. & Strohl, K. P. Inheritance of ventilatory behavior in rodent models. Respir. Physiol. 121, 247\u2013256 (2000).","journal-title":"Respir. Physiol."},{"key":"99922_CR96","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1152\/jappl.2001.91.5.1962","volume":"91","author":"F Han","year":"2001","unstructured":"Han, F., Subramanian, S., Dick, T. E., Dreshaj, I. A. & Strohl, K. P. Ventilatory behavior after hypoxia in C57BL\/6J and A\/J mice. J. Appl. Physiol. 91, 1962\u20131970 (2001).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR97","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1152\/japplphysiol.00785.2001","volume":"92","author":"F Han","year":"2002","unstructured":"Han, F., Subramanian, S., Price, E. R., Nadeau, J. & Strohl, K. P. Periodic breathing in the mouse. J. Appl. Physiol. 92, 1133\u20131140 (2002).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR98","doi-asserted-by":"crossref","first-page":"R1371","DOI":"10.1152\/ajpcell.1994.267.5.C1371","volume":"267","author":"CG Tankersley","year":"1994","unstructured":"Tankersley, C. G., Fitzgerald, R. S. & Kleeberger, S. R. Differential control of ventilation among inbred strains of mice. Am. J. Physiol. 267, R1371\u2013R1377 (1994).","journal-title":"Am. J. Physiol."},{"key":"99922_CR99","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1152\/jappl.2000.88.6.2310","volume":"88","author":"CG Tankersley","year":"2000","unstructured":"Tankersley, C. G., Elston, R. C. & Schnell, A. H. Genetic determinants of acute hypoxic ventilation: patterns of inheritance in mice. J. Appl. Physiol. 88, 2310\u20132318 (2000).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR100","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1152\/jappl.2001.90.4.1615","volume":"90","author":"CG Tankersley","year":"2001","unstructured":"Tankersley, C. G. Selected contribution: variation in acute hypoxic ventilatory response is linked to mouse chromosome 9. J. Appl. Physiol. 90, 1615\u20131622 (2001).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR101","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S1569-9048(03)00035-1","volume":"135","author":"CG Tankersley","year":"2003","unstructured":"Tankersley, C. G. Genetic aspects of breathing: On interactions between hypercapnia and hypoxia. Respir. Physiol. Neurobiol. 135, 167\u2013178 (2003).","journal-title":"Respir. Physiol. Neurobiol."},{"key":"99922_CR102","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.resp.2012.05.001","volume":"183","author":"MW Moore","year":"2012","unstructured":"Moore, M. W. et al. Two weeks of buspirone protects against posthypoxic ventilatory pauses in the C57BL\/6J mouse strain. Respir. Physiol. Neurobiol. 183, 35\u201340 (2012).","journal-title":"Respir. Physiol. Neurobiol."},{"key":"99922_CR103","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.resp.2014.03.014","volume":"200","author":"MW Moore","year":"2014","unstructured":"Moore, M. W. et al. Effects of orexin 2 receptor activation on apnea in the C57BL\/6J mouse. Respir. Physiol. Neurobiol. 200, 118\u2013125 (2014).","journal-title":"Respir. Physiol. Neurobiol."},{"key":"99922_CR104","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1080\/01902140600586458","volume":"31","author":"H Groeben","year":"2005","unstructured":"Groeben, H., Meier, S., Tankersley, C. G., Mitzner, W. & Brown, R. H. Heritable and pharmacological influences on pauses and apneas in inbred mice during anesthesia and emergence. Exper. Lung Res. 31, 839\u2013853 (2005).","journal-title":"Exper. Lung Res."},{"key":"99922_CR105","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1152\/japplphysiol.00166.2003","volume":"95","author":"ER Price","year":"2003","unstructured":"Price, E. R., Han, F., Dick, T. E. & Strohl, K. P. 7-nitroindazole and posthypoxic ventilatory behavior in the A\/J and C57BL\/6J mouse strains. J. Appl. Physiol. 95, 1097\u20131104 (2003).","journal-title":"J. Appl. Physiol."},{"issue":"103","key":"99922_CR106","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1152\/japplphysiol.01287.2006","volume":"1985","author":"M Yamauchi","year":"2007","unstructured":"Yamauchi, M., Dostal, J. & Strohl, K. P. Acetazolamide protects against posthypoxic unstable breathing in the C57BL\/6J mouse. J. Appl. Physiol. 1985(103), 1263\u20131268 (2007).","journal-title":"J. Appl. Physiol."},{"issue":"113","key":"99922_CR107","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1152\/japplphysiol.01394.2011","volume":"1985","author":"CB Gillombardo","year":"2012","unstructured":"Gillombardo, C. B. et al. Identification of novel mouse genes conferring posthypoxic pauses. J. Appl. Physiol. 1985(113), 167\u2013174 (2012).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR108","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.resp.2011.04.021","volume":"177","author":"S Chai","year":"2011","unstructured":"Chai, S., Gillombardo, C. B., Donovan, L. & Strohl, K. P. Morphological differences of the carotid body among C57\/BL6 (B6), A\/J, and CSS B6A1 mouse strains. Respir. Physiol. Neurobiol. 177, 265\u2013272 (2011).","journal-title":"Respir. Physiol. Neurobiol."},{"key":"99922_CR109","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1152\/japplphysiol.00739.2002","volume":"9","author":"S Yamaguchi","year":"2003","unstructured":"Yamaguchi, S. et al. Structural and functional differences of the carotid body between DBA\/2J and A\/J strains of mice. J. Appl. Physiol. 9, 1536\u20131542 (2003).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR110","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/0-387-31311-7_16","volume":"580","author":"S Yamaguchi","year":"2006","unstructured":"Yamaguchi, S. et al. Genetic influence on carotid body structure in DBA\/2J and A\/J strains of mice. Adv. Exper. Med. Biol. 580, 105\u2013109 (2006).","journal-title":"Adv. Exper. Med. Biol."},{"key":"99922_CR111","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/j.1469-7793.1998.273bi.x","volume":"511","author":"DD Kline","year":"1998","unstructured":"Kline, D. D., Yang, T., Huang, P. L. & Prabhakar, N. R. Altered respiratory responses to hypoxia in mutant mice deficient in neuronal nitric oxide synthase. J. Physiol. 511, 273\u2013287 (1998).","journal-title":"J. Physiol."},{"issue":"88","key":"99922_CR112","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1152\/jappl.2000.88.4.1496","volume":"1985","author":"DD Kline","year":"2000","unstructured":"Kline, D. D., Yang, T., Premkumar, D. R., Thomas, A. J. & Prabhakar, N. R. Blunted respiratory responses to hypoxia in mutant mice deficient in nitric oxide synthase-3. J. Appl. Physiol. 1985(88), 1496\u20131508 (2000).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR113","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1046\/j.1523-1755.1998.00913.x","volume":"53","author":"H Ling","year":"1998","unstructured":"Ling, H. et al. Effect of hypoxia on proximal tubules isolated from nitric oxide synthase knockout mice. Kidney Int. 53, 1642\u20131646 (1998).","journal-title":"Kidney Int."},{"key":"99922_CR114","doi-asserted-by":"publisher","first-page":"590541","DOI":"10.1155\/2014\/590541","volume":"2014","author":"T Takahashi","year":"2014","unstructured":"Takahashi, T. & Harris, R. C. Role of endothelial nitric oxide synthase in diabetic nephropathy: Lessons from diabetic eNOS knockout mice. J. Diabetes Res. 2014, 590541 (2014).","journal-title":"J. Diabetes Res."},{"key":"99922_CR115","doi-asserted-by":"publisher","first-page":"13176","DOI":"10.1073\/pnas.93.23.13176","volume":"93","author":"EG Shesely","year":"1996","unstructured":"Shesely, E. G. et al. Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. USA 93, 13176\u201313181 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"99922_CR116","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1161\/01.HYP.33.6.1359","volume":"33","author":"HM Stauss","year":"1999","unstructured":"Stauss, H. M., G\u00f6decke, A., Mrowka, R., Schrader, J. & Persson, P. B. Enhanced blood pressure variability in eNOS knockout mice. Hypertension 33, 1359\u20131363 (1999).","journal-title":"Hypertension"},{"key":"99922_CR117","doi-asserted-by":"publisher","first-page":"7111","DOI":"10.1038\/s41598-017-07768-7","volume":"7","author":"C Manicam","year":"2017","unstructured":"Manicam, C. et al. Compensatory vasodilator mechanisms in the ophthalmic artery of endothelial nitric oxide synthase gene knockout mice. Sci. Rep. 7, 7111 (2017).","journal-title":"Sci. Rep."},{"key":"99922_CR118","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1002\/mrm.26870","volume":"79","author":"SX Cui","year":"2018","unstructured":"Cui, S. X. & Epstein, F. H. MRI assessment of coronary microvascular endothelial nitric oxide synthase function using myocardial T1 mapping. Magn. Reson. Med. 79, 2246\u20132253 (2018).","journal-title":"Magn. Reson. Med."},{"key":"99922_CR119","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1097\/PHM.0000000000000904","volume":"97","author":"S Li","year":"2018","unstructured":"Li, S. et al. Impaired cognitive performance in endothelial nitric oxide synthase knockout mice after ischemic stroke: A pilot study. Am. J. Phys. Med. Rehabil. 97, 492\u2013499 (2018).","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"99922_CR120","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41598-017-18260-7","volume":"8","author":"Y Oe","year":"2018","unstructured":"Oe, Y. et al. Hepatic dysfunction and thrombocytopenia induced by excess sFlt1 in mice lacking endothelial nitric oxide synthase. Sci. Rep. 8, 102 (2018).","journal-title":"Sci. Rep."},{"key":"99922_CR121","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1152\/japplphysiol.01042.2002","volume":"94","author":"W Kozak","year":"2003","unstructured":"Kozak, W. & Kozak, A. Genetic models in applied physiology. Differential role of nitric oxide synthase isoforms in fever of different etiologies: Studies using Nos gene-deficient mice. J. Appl. Physiol. 94, 2534\u20132544 (2003).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR122","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/377239a0","volume":"377","author":"PL Huang","year":"1995","unstructured":"Huang, P. L. et al. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 377, 239\u2013242 (1995).","journal-title":"Nature"},{"key":"99922_CR123","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1097\/00004647-199609000-00023","volume":"16","author":"Z Huang","year":"1996","unstructured":"Huang, Z. et al. Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine. J. Cereb. Blood. Flow Metab. 16, 981\u2013987 (1996).","journal-title":"J. Cereb. Blood. Flow Metab."},{"key":"99922_CR124","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1590\/S0100-879X1999001100005","volume":"32","author":"PL Huang","year":"1999","unstructured":"Huang, P. L. Neuronal and endothelial nitric oxide synthase gene knockout mice. Braz. J. Med. Biol. Res. 32, 1353\u20131359 (1999).","journal-title":"Braz. J. Med. Biol. Res."},{"key":"99922_CR125","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1172\/JCI0214066","volume":"109","author":"JB Hodgin","year":"2002","unstructured":"Hodgin, J. B., Knowles, J. W., Kim, H. S., Smithies, O. & Maeda, N. Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice. J. Clin. Invest. 109, 541\u2013548 (2002).","journal-title":"J. Clin. Invest."},{"key":"99922_CR126","first-page":"H1717","volume":"271","author":"J Ma","year":"1996","unstructured":"Ma, J. et al. L-NNA-sensitive regional cerebral blood flow augmentation during hypercapnia in type III NOS mutant mice. Am. J. Physiol. 271, H1717\u2013H1719 (1996).","journal-title":"Am. J. Physiol."},{"key":"99922_CR127","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.resp.2008.06.006","volume":"164","author":"M Behan","year":"2008","unstructured":"Behan, M. & Wenninger, J. M. Sex steroidal hormones and respiratory control. Respir. Physiol. Neurobiol. 164, 213\u2013221 (2008).","journal-title":"Respir. Physiol. Neurobiol."},{"key":"99922_CR128","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1097\/00000542-199804000-00009","volume":"88","author":"A Dahan","year":"1998","unstructured":"Dahan, A., Sarton, E., Teppema, L. & Olievier, C. Sex-related differences in the influence of morphine on ventilatory control in humans. Anesthesiology 88, 903\u2013913 (1998).","journal-title":"Anesthesiology"},{"key":"99922_CR129","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1152\/japplphysiol.90802.2008","volume":"106","author":"JM Wenninger","year":"2009","unstructured":"Wenninger, J. M., Olson, E. B. Jr., Cotter, C. J., Thomas, C. F. & Behan, M. Hypoxic and hypercapnic ventilatory responses in aging male vs. aging female rats. J. Appl. Physiol. 106, 1522\u20131528 (2009).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR130","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00335-005-0112-1","volume":"17","author":"LC Solberg","year":"2006","unstructured":"Solberg, L. C. et al. A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice. Mamm. Genome 17, 129\u2013146 (2006).","journal-title":"Mamm. Genome"},{"key":"99922_CR131","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.nbd.2017.01.008","volume":"101","author":"SM Villiere","year":"2017","unstructured":"Villiere, S. M. et al. Seizure-associated central apnea in a rat model: Evidence for resetting the respiratory rhythm and activation of the diving reflex. Neurobiol. Dis. 101, 8\u201315 (2017).","journal-title":"Neurobiol. Dis."},{"key":"99922_CR132","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/0034-5687(78)90103-2","volume":"32","author":"MA Epstein","year":"1978","unstructured":"Epstein, M. A. & Epstein, R. A. A theoretical analysis of the barometric method for measurement of tidal volume. Respir. Physiol. 32, 105\u2013120 (1978).","journal-title":"Respir. Physiol."},{"key":"99922_CR133","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/01.RES.47.1.1","volume":"47","author":"S Wallenstein","year":"1980","unstructured":"Wallenstein, S., Zucker, C. L. & Fleiss, J. C. Some statistical methods useful in circulation research. Circ. Res. 47, 1\u20139 (1980).","journal-title":"Circ. Res."},{"key":"99922_CR134","first-page":"752","volume-title":"Statistical Principles of Experimental Design","author":"BJ Winer","year":"1971","unstructured":"Winer, B. J. Statistical Principles of Experimental Design 752\u2013809 (McGraw-Hill, 1971)."},{"key":"99922_CR135","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1083\/jcb.200611141","volume":"177","author":"G Cumming","year":"2007","unstructured":"Cumming, G., Fidler, F., David, L. & Vaux, D. L. Error bars in experimental biology. J. Cell. Biol. 177, 7\u201311 (2007).","journal-title":"J. Cell. Biol."},{"key":"99922_CR136","doi-asserted-by":"crossref","unstructured":"Getsy, P.M., Sundararajan, S., May, W.J., von Schill, G., McLaughlin, D.K., Palmer, L.A. & Lewis, S.J. Short-term facilitation of breathing upon cessation of hypoxic challenge is impaired in male but not female endothelial NOS knock-out mice. Sci. Rep. in revision (2021).","DOI":"10.1038\/s41598-021-97322-3"},{"key":"99922_CR137","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/s41366-019-0330-3","volume":"44","author":"L Zhao","year":"2020","unstructured":"Zhao, L. et al. Even a low dose of tamoxifen profoundly induces adipose tissue browning in female mice. Int. J. Obes. (Lond) 44, 226\u2013234 (2020).","journal-title":"Int. J. Obes. (Lond)"},{"key":"99922_CR138","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s11357-010-9164-6","volume":"33","author":"M Sanchez-Alavez","year":"2011","unstructured":"Sanchez-Alavez, M., Alboni, S. & Conti, B. Sex- and age-specific differences in core body temperature of C57Bl\/6 mice. Age (Dordr) 33, 89\u201399 (2011).","journal-title":"Age (Dordr)"},{"key":"99922_CR139","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1126\/science.1079368","volume":"299","author":"E Nisoli","year":"2003","unstructured":"Nisoli, E. et al. Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide. Science 299, 896\u2013899 (2003).","journal-title":"Science"},{"key":"99922_CR140","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1080\/07420520600827111","volume":"23","author":"M Arraj","year":"2006","unstructured":"Arraj, M. & Lemmer, B. Circadian rhythms in heart rate, motility, and body temperature of wild-type C57 and eNOS knock-out mice under light-dark, free-run, and after time zone transition. Chronobiol. Int. 23, 795\u2013812 (2006).","journal-title":"Chronobiol. Int."},{"key":"99922_CR141","doi-asserted-by":"publisher","first-page":"0192724","DOI":"10.1371\/journal.pone.0192724","volume":"13","author":"ND Detweiler","year":"2018","unstructured":"Detweiler, N. D., Vigil, K. G., Resta, T. C., Walker, B. R. & Jernigan, N. L. Role of acid-sensing ion channels in hypoxia- and hypercapnia-induced ventilatory responses. PLoS ONE 13, 0192724 (2018).","journal-title":"PLoS ONE"},{"key":"99922_CR142","doi-asserted-by":"publisher","first-page":"R190","DOI":"10.1152\/ajpregu.00065.2019","volume":"317","author":"CE Giannakopoulou","year":"2019","unstructured":"Giannakopoulou, C. E. et al. Regulation of breathing pattern by IL-10. Am. J. Physiol. Regul. Integr. Comp. Physiol. 317, R190\u2013R202 (2019).","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"99922_CR143","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.resp.2019.03.002","volume":"263","author":"Y Hirata","year":"2019","unstructured":"Hirata, Y., Suzuki, Y., Tominaga, M. & Oku, Y. TRPM8 channel is involved in the ventilatory response to CO2 mediating hypercapnic Ca2+ responses. Respir. Physiol. Neurobiol. 263, 20\u201325 (2019).","journal-title":"Respir. Physiol. Neurobiol."},{"key":"99922_CR144","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1002\/jemt.10193","volume":"59","author":"H Ichikawa","year":"2002","unstructured":"Ichikawa, H. Innervation of the carotid body: Immunohistochemical, denervation, and retrograde tracing studies. Microsc. Res. Tech. 59, 188\u2013195 (2002).","journal-title":"Microsc. Res. Tech."},{"key":"99922_CR145","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/978-1-4615-2572-1_33","volume":"360","author":"PA Grimes","year":"1994","unstructured":"Grimes, P. A., Lahiri, S., Stone, R., Mokashi, A. & Chug, D. Nitric oxide synthase occurs in neurons and nerve fibers of the carotid body. Adv. Exp. Med. Biol. 360, 221\u2013224 (1994).","journal-title":"Adv. Exp. Med. Biol."},{"key":"99922_CR146","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/cne.903360308","volume":"336","author":"ZZ Wang","year":"1993","unstructured":"Wang, Z. Z., Bredt, D. S., Fidone, S. J. & Stensaas, L. J. Neurons synthesizing nitric oxide innervate the mammalian carotid body. J. Comp. Neurol. 336, 419\u2013432 (1993).","journal-title":"J. Comp. Neurol."},{"key":"99922_CR147","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/0306-4522(94)90221-6","volume":"60","author":"ZZ Wang","year":"1994","unstructured":"Wang, Z. Z., Stensaas, L. J., Bredt, D. S., Dinger, B. & Fidone, S. J. Localization and actions of nitric oxide in the cat carotid body. Neuroscience 60, 275\u2013286 (1994).","journal-title":"Neuroscience"},{"key":"99922_CR148","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.aanat.2005.03.006","volume":"187","author":"MC Dvorakova","year":"2005","unstructured":"Dvorakova, M. C. & Kummer, W. Immunohistochemical evidence for species-specific coexistence of catecholamines, serotonin, acetylcholine and nitric oxide in glomus cells of rat and guinea pig aortic bodies. Ann Anat. 187, 323\u2013331 (2005).","journal-title":"Ann Anat."},{"key":"99922_CR149","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00441-006-0178-4","volume":"325","author":"Y Yamamoto","year":"2006","unstructured":"Yamamoto, Y., K\u00f6nig, P., Henrich, M., Dedio, J. & Kummer, W. Hypoxia induces production of nitric oxide and reactive oxygen species in glomus cells of rat carotid body. Cell Tissue Res. 325, 3\u201311 (2006).","journal-title":"Cell Tissue Res."},{"key":"99922_CR150","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.acthis.2016.09.007","volume":"118","author":"DY Atanasova","year":"2016","unstructured":"Atanasova, D. Y., Dimitrov, N. D. & Lazarov, N. E. Expression of nitric oxide-containing structures in the rat carotid body. Acta Histochem. 118, 770\u2013775 (2016).","journal-title":"Acta Histochem."},{"key":"99922_CR151","doi-asserted-by":"publisher","first-page":"151500","DOI":"10.1016\/j.acthis.2019.151500","volume":"122","author":"DY Atanasova","year":"2020","unstructured":"Atanasova, D. Y., Dandov, A. D., Dimitrov, N. D. & Lazarov, N. E. Histochemical and immunohistochemical localization of nitrergic structures in the carotid body of spontaneously hypertensive rats. Acta Histochem. 122, 151500 (2020).","journal-title":"Acta Histochem."},{"key":"99922_CR152","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0034-5687(99)00019-5","volume":"115","author":"NR Prabhakar","year":"1999","unstructured":"Prabhakar, N. R. NO and CO as second messengers in oxygen sensing in the carotid body. Respir. Physiol. 115, 161\u2013168 (1999).","journal-title":"Respir. Physiol."},{"key":"99922_CR153","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/0006-8993(93)90132-7","volume":"625","author":"NR Prabhakar","year":"1993","unstructured":"Prabhakar, N. R., Kumar, G. K., Chang, C. H., Agani, F. H. & Haxhiu, M. A. Nitric oxide in the sensory function of the carotid body. Brain Res. 625, 16\u201322 (1993).","journal-title":"Brain Res."},{"key":"99922_CR154","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/0306-4522(94)00437-A","volume":"65","author":"ZZ Wang","year":"1995","unstructured":"Wang, Z. Z., Stensaas, L. J., Dinger, B. G. & Fidone, S. J. Nitric oxide mediates chemoreceptor inhibition in the cat carotid body. Neuroscience 65, 217\u2013229 (1995).","journal-title":"Neuroscience"},{"key":"99922_CR155","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1152\/jn.1999.81.4.1449","volume":"81","author":"BA Summers","year":"1999","unstructured":"Summers, B. A., Overholt, J. L. & Prabhakar, N. R. (1999) Nitric oxide inhibits L-type Ca2+ current in glomus cells of the rabbit carotid body via a cGMP-independent mechanism. J. Neurophysiol. 81, 1449\u20131457 (1999).","journal-title":"J. Neurophysiol."},{"key":"99922_CR156","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/978-1-4419-9280-2_45","volume":"536","author":"V Vald\u00e9s","year":"2003","unstructured":"Vald\u00e9s, V., Mosqueira, M. & Iturriaga, R. Contribution of neural and endothelial isoforms of the nitric oxide synthase to the inhibitory effects of NO on the cat carotid body. Adv. Exp. Med. Biol. 536, 345\u2013351 (2003).","journal-title":"Adv. Exp. Med. Biol."},{"key":"99922_CR157","doi-asserted-by":"publisher","first-page":"L57","DOI":"10.1152\/ajplung.00494.2001","volume":"284","author":"V Vald\u00e9s","year":"2003","unstructured":"Vald\u00e9s, V., Mosqueira, M., Rey, S., Del Rio, R. & Iturriaga, R. Inhibitory effects of NO on carotid body: Contribution of neural and endothelial nitric oxide synthase isoforms. Am. J. Physiol. Lung Cell. Mol. Physiol. 284, L57\u2013L68 (2003).","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"99922_CR158","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.resp.2012.03.019","volume":"184","author":"EA Moya","year":"2012","unstructured":"Moya, E. A., Alcayaga, J. & Iturriaga, R. NO modulation of carotid body chemoreception in health and disease. Respir. Physiol. Neurobiol. 184, 158\u2013164 (2012).","journal-title":"Respir. Physiol. Neurobiol."},{"key":"99922_CR159","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1007\/0-306-46825-5_76","volume":"475","author":"R Iturriaga","year":"2000","unstructured":"Iturriaga, R., Villanueva, S. & Alcayaga, J. Nitric oxide modulation of carotid chemoreception. Adv. Exp. Med. Biol. 475, 761\u2013768 (2000).","journal-title":"Adv. Exp. Med. Biol."},{"issue":"89","key":"99922_CR160","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1152\/jappl.2000.89.3.1005","volume":"1985","author":"R Iturriaga","year":"2000","unstructured":"Iturriaga, R., Villanueva, S. & Mosqueira, M. Dual effects of nitric oxide on cat carotid body chemoreception. J. Appl. Physiol. 1985(89), 1005\u20131012 (2000).","journal-title":"J. Appl. Physiol."},{"key":"99922_CR161","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S1569-9048(02)00020-4","volume":"131","author":"M Mosqueira","year":"2002","unstructured":"Mosqueira, M. & Iturriaga, R. Carotid body chemosensory excitation induced by nitric oxide: Involvement of oxidative metabolism. Respir Physiol Neurobiol. 131, 175\u2013187 (2002).","journal-title":"Respir Physiol Neurobiol."},{"key":"99922_CR162","doi-asserted-by":"publisher","first-page":"e134174","DOI":"10.1172\/jci.insight.134174","volume":"5","author":"B Gaston","year":"2020","unstructured":"Gaston, B. et al. Voltage-gated potassium channel proteins and stereoselective S-nitroso-l-cysteine signaling. JCI Insight 5, e134174 (2020).","journal-title":"JCI Insight"},{"key":"99922_CR163","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01031.2020","author":"PM Getsy","year":"2021","unstructured":"Getsy, P. M., Sundararajan, S. & Lewis, S. J. Carotid sinus nerve transection abolishes the facilitation of breathing that occurs upon cessation of a hypercapnic gas challenge in male mice. J Appl Physiol. https:\/\/doi.org\/10.1152\/japplphysiol.01031.2020 (2021).","journal-title":"J Appl Physiol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-99922-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-99922-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-99922-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T09:39:17Z","timestamp":1675762757000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-99922-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,18]]},"references-count":163,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["99922"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-99922-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,18]]},"assertion":[{"value":"1 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20557"}}