{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:22:04Z","timestamp":1787761324072,"version":"build-2784847793"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is conflicting evidence regarding the effect of coronavirus disease (COVID-19) in pregnancy. Risk factors for COVID-19 overlap with risk factors for pregnancy complications. We aimed to assess the effects of the COVID-19 pandemic and confirmed SARS-CoV-2 infection on pregnancy outcomes. A\u00a0retrospective interrupted time-series and matched cohort analysis\u00a0was performed. Singleton pregnancies completed between 1st January 2016 and 31st January 2021 were included. Trends in outcomes were analysed over time. Modelled COVID-19 transmission data were applied to deliveries since 1st January 2020 to assign a risk of COVID-19 to each pregnancy, and incorporated into a regression model of birthweight. Confirmed COVID-19 cases were matched to controls delivered in the pre-pandemic period, and maternal and neonatal outcomes compared. 43,802 pregnancies were included, with 8343 in the model of birthweight. There was no increase in the risk of stillbirth (<jats:italic>p<\/jats:italic>\u2009=\u20090.26) or neonatal death (<jats:italic>p<\/jats:italic>\u2009=\u20090.64) during the pandemic. There was no association between modelled COVID-19 attack rate (%) in any trimester and birthweight (first trimester <jats:italic>p<\/jats:italic>\u2009=\u20090.50, second <jats:italic>p<\/jats:italic>\u2009=\u20090.15, third <jats:italic>p<\/jats:italic>\u2009=\u20090.16). 214 COVID-positive women were matched to controls. Preterm birth was more common in symptomatic cases (14\/62, 22.6%) compared to asymptomatic cases (9\/109, 8.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.008) and controls (5\/62, 8.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.025). Iatrogenic preterm birth was more common in cases (21\/214, 9.8%) than controls (9\/214, 4.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). All other examined outcomes were similar between groups. There was no significant impact of COVID-19 on the examined birth outcomes available. Symptomatic COVID-19 should be considered a risk factor for preterm birth, possibly due to an increase in iatrogenic deliveries for maternal indications.<\/jats:p>","DOI":"10.1038\/s41598-022-04898-5","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T11:03:20Z","timestamp":1642503800000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["The impact of COVID-19 on pregnancy outcomes in a diverse cohort in England"],"prefix":"10.1038","volume":"12","author":[{"given":"Michael","family":"Wilkinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward D.","family":"Johnstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise E.","family":"Simcox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny E.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,18]]},"reference":[{"key":"4898_CR1","unstructured":"The World Health Organization (WHO). 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