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It is a component of both stress granules and neuronal RNA granules and is implicated in neurodegenerative disease, synaptic plasticity and long-term memory formation. Our previous work suggested that Caprin1 also plays a role in the response of the cochlea to stress. Here, targeted inner ear-deletion of\n                    <jats:italic>Caprin1<\/jats:italic>\n                    in mice leads to an early onset, progressive hearing loss. Auditory brainstem responses from\n                    <jats:italic>Caprin1<\/jats:italic>\n                    -deficient mice show reduced thresholds, with a significant reduction in wave-I amplitudes compared to wildtype. Whilst hair cell structure and numbers were normal, the inner hair cell-spiral ganglion neuron (IHC-SGN) synapse revealed abnormally large post-synaptic GluA2 receptor puncta, a defect consistent with the observed wave-I reduction. Unlike wildtype mice, mild-noise-induced hearing threshold shifts in\n                    <jats:italic>Caprin1<\/jats:italic>\n                    -deficient mice did not recover. Oxidative stress triggered TIA-1\/HuR-positive stress granule formation in\n                    <jats:italic>ex-vivo<\/jats:italic>\n                    cochlear explants from\n                    <jats:italic>Caprin1-<\/jats:italic>\n                    deficient mice, showing that stress granules could still be induced. Taken together, these findings suggest that Caprin1 plays a key role in maintenance of auditory function, where it regulates the normal status of the IHC-SGN synapse.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-05657-2","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T06:16:32Z","timestamp":1644819392000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Targeted deletion of the RNA-binding protein Caprin1 leads to progressive hearing loss and impairs recovery from noise exposure in mice"],"prefix":"10.1038","volume":"12","author":[{"given":"Lisa S.","family":"Nolan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana-Cl\u00e1udia","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anwen","family":"Bullen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily R.","family":"Towers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen P.","family":"Steel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally J.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan E.","family":"Gale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"5657_CR1","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.4049\/jimmunol.172.4.2389","volume":"172","author":"B Grill","year":"2004","unstructured":"Grill, B. et al. 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