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It is unknown whether the same phenomenon might be found in regions other than the cortico-basal ganglia circuit. We hypothesized that using magnetoencephalography to assess phase-amplitude coupling in the whole brain can characterize Parkinson\u2019s disease. We recorded resting-state magnetoencephalographic signals in patients with Parkinson\u2019s disease and in healthy age- and sex-matched participants. We compared whole-brain signals from the two groups, evaluating the power spectra of 3 frequency bands (alpha, 8\u201312\u00a0Hz; beta, 13\u201325\u00a0Hz; gamma, 50\u2013100\u00a0Hz) and the coupling between gamma amplitude and alpha or beta phases. Patients with Parkinson\u2019s disease showed significant beta\u2013gamma phase-amplitude coupling that was widely distributed in the sensorimotor, occipital, and temporal cortices; healthy participants showed such coupling only in parts of the somatosensory and temporal cortices. Moreover, beta- and gamma-band power differed significantly between participants in the two groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Finally, beta\u2013gamma phase-amplitude coupling in the sensorimotor cortices correlated significantly with motor symptoms of Parkinson\u2019s disease (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05); beta- and gamma-band power did not. We thus demonstrated that beta\u2013gamma phase-amplitude coupling in the resting state characterizes Parkinson\u2019s disease.<\/jats:p>","DOI":"10.1038\/s41598-022-05901-9","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T11:05:49Z","timestamp":1643886349000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Magnetoencephalography detects phase-amplitude coupling in Parkinson\u2019s disease"],"prefix":"10.1038","volume":"12","author":[{"given":"Masataka","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takufumi","family":"Yanagisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Fukuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Tani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Oshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Mihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Kajiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Kishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"5901_CR1","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1093\/brain\/awf156","volume":"125","author":"D Williams","year":"2002","unstructured":"Williams, D. et al. 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