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We aimed to analyze the prevalence and associations of MetS in patients with Alcohol Use Disorder (AUD). Cross-sectional study in heavy drinkers admitted for the treatment of AUD between 2013 and 2017. Medical comorbidity, anthropometric data, alcohol use and biological parameters were obtained. MetS was established according to the harmonized definition. A total of\u00a0728 patients (22% women) were included; median age was 47\u00a0years (IQR: 40\u201353.5), median alcohol consumption was 160\u00a0g\/day (IQR: 115\u2013240) and prevalence of MetS was 13.9%. The multivariate analysis showed a significant dose\u2013response effect of estimated glomerular filtration (eGFR) and MetS: relative to patients with eGFR\u2009&gt;\u200990\u00a0mL\/min, those with eGFR (60\u201390\u00a0mL\/min) and those with eGFR\u2009&lt;\u200960\u00a0mL\/min were 1.93 times (95% CI 1.18\u20133.15) and 5.61 times (95% CI 1.66\u201319.0) more likely to have MetS, respectively. MetS was significantly associated with hyperuricemia (OR 2.28, 95% CI 1.36\u20133.82) and elevated serum GGT (OR 3.67, 95% CI 1.80\u20137.46). Furthermore, for every increase of 1\u00a0year in age, the probability of MetS increased significantly (OR 1.03, 95% CI 1.01\u20131.05). MetS in heavy drinkers is independently associated with reduced kidney function and metabolic risk factors including hyperuricemia and elevated serum GGT.<\/jats:p>","DOI":"10.1038\/s41598-022-06010-3","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T11:03:20Z","timestamp":1645009400000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Prevalence and associations of metabolic syndrome in patients with alcohol use disorder"],"prefix":"10.1038","volume":"12","author":[{"given":"Anna","family":"Hern\u00e1ndez-Rubio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arantza","family":"Sanvisens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferran","family":"Bolao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Cach\u00f3n-Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Garcia-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Short","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Bataller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Muga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,16]]},"reference":[{"key":"6010_CR1","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1177\/1753944717711379","volume":"11","author":"Y Rochlani","year":"2017","unstructured":"Rochlani, Y., Pothineni, N. 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