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A total of 185 clinical isolates of <jats:italic>P. aeruginosa<\/jats:italic> were collected from 5 university-affiliated hospitals in Ahvaz, southwest Iran. The disk diffusion method was applied to assess the quinolone resistance pattern. The presence of <jats:italic>qnrA<\/jats:italic>, <jats:italic>qnrB<\/jats:italic>, <jats:italic>qnrC<\/jats:italic>, <jats:italic>qnrD<\/jats:italic>, <jats:italic>qnrS<\/jats:italic>, <jats:italic>qepA<\/jats:italic>, and <jats:italic>aac(6\u2032)-Ib-cr<\/jats:italic> genes was investigated by the polymerase chain reaction (PCR) method. Overall, 120 (64.9%) isolates were non-susceptible to quinolones. The most and the less quinolone resistance rates were observed against ciprofloxacin (59.4%) and ofloxacin (45.9%), respectively. The prevalence rates of <jats:italic>qnr<\/jats:italic> genes were as follows: <jats:italic>qnrA<\/jats:italic> (25.8%), <jats:italic>qnrB<\/jats:italic> (29.2%), and <jats:italic>qnrS<\/jats:italic> (20.8%). The <jats:italic>qnrB<\/jats:italic> gene was the most common type of <jats:italic>qnr<\/jats:italic> genes. The <jats:italic>qnr<\/jats:italic> genes were occurred in 37.5% (n\u2009=\u200945\/120) of quinolne-resistant\u00a0isolates, simultaneously. The <jats:italic>qnrC<\/jats:italic>, <jats:italic>qnrD<\/jats:italic>, <jats:italic>qepA<\/jats:italic>, and <jats:italic>aac(6\u2032)-Ib-cr<\/jats:italic> genes were not recognized in any isolates. In conclusion, the ofloxacin was the most effective quinolone. This study was the first to shed light on the prevalence of PMQR genes among <jats:italic>P. aeruginosa<\/jats:italic> isolates in southwest Iran.<\/jats:p>","DOI":"10.1038\/s41598-022-06128-4","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T11:05:58Z","timestamp":1644491158000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Occurrence of plasmid-mediated quinolone resistance genes in Pseudomonas aeruginosa strains isolated from clinical specimens in southwest Iran: a multicentral study"],"prefix":"10.1038","volume":"12","author":[{"given":"Morteza","family":"Saki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Farajzadeh Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakineh","family":"Seyed-Mohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aram","family":"Asareh Zadegan Dezfuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Shahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Tabasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hojat","family":"Veisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raziyeh","family":"Keshavarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Khani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"6128_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12941-020-00389-5","volume":"19","author":"Z Chegini","year":"2020","unstructured":"Chegini, Z. et al. 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