{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T19:14:48Z","timestamp":1785179688117,"version":"3.55.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/22999-3"],"award-info":[{"award-number":["2018\/22999-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/18031-5"],"award-info":[{"award-number":["2015\/18031-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This cross-sectional study aimed to compare the waveform morphology through noninvasive intracranial pressure (ICP-NI) measurement between patients with migraine and controls, and to analyze the association with clinical variables. Twenty-nine women with migraine, age 32.4 (11.2) years and headache frequency of 12.6 (7.5) days per month and twenty-nine women without headache, age 32.1 (9.0) years, were evaluated. Pain intensity, migraine disability, allodynia, pain catastrophizing, central sensitization and depression were evaluated. The ICP-NI monitoring was performed by a valid method consisting of an extracranial deformation sensor positioned in the patients\u2019 scalp, which allowed registration of intracranial pressure waveforms. Heart rate and blood pressure measurements were simultaneously recorded during 20\u00a0min in the supine position. The analyzed parameter was the P2\/P1 ratio based on mean pulse per minute which P1 represents the percussion wave related to the arterial blood pression maximum and P2 the tidal wave, middle point between the P1 maximum and the dicrotic notch. There was no between-groups difference in the P2\/P1 ratio (mean difference: 0.04, IC95%: -0.07 to 0.16, <jats:italic>p<\/jats:italic>\u2009=\u20090.352, F (1,1)\u2009=\u20090.881) adjusted by body mass index covariable. The Multiple Linear Regression showed non-statistical significance [F (5,44)\u2009=\u20091.104; <jats:italic>p<\/jats:italic>\u2009=\u20090.372; R<jats:sup>2<\/jats:sup>\u2009=\u20090.11)] between the P2\/P1 ratio and body mass index, presence of migraine, central sensitization, pain catastrophizing and depression. We found no correlation (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) between P2\/P1 ratio and migraine frequency, migraine onset, pain intensity, pain intensity at day of examination, disability, allodynia. Migraine patients did not present alterations in the waveform morphology through ICP-NI compared to women without headache and no association with clinical variables was found.<\/jats:p>","DOI":"10.1038\/s41598-022-06258-9","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T11:03:20Z","timestamp":1645009400000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Noninvasive intracranial pressure monitoring in women with migraine"],"prefix":"10.1038","volume":"12","author":[{"given":"Denise Martineli","family":"Rossi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora","family":"Bevilaqua-Grossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio","family":"Mascarenhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo Celso Dutra","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Ferreira","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Carmona","family":"Vendramim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella Vieira","family":"Philbois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fab\u00edola","family":"Dach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Jos\u00e9","family":"Tallarico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamaria Siriani","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,16]]},"reference":[{"issue":"8","key":"6258_CR1","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1080\/14728222.2017.1353603","volume":"21","author":"J Nijs","year":"2017","unstructured":"Nijs, J. et al. Sleep disturbances and severe stress as glial activators: Key targets for treating central sensitization in chronic pain patients?. Expert Opin. Ther. Targets 21(8), 817\u2013826. https:\/\/doi.org\/10.1080\/14728222.2017.1353603 (2017).","journal-title":"Expert Opin. Ther. Targets"},{"issue":"5","key":"6258_CR2","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1097\/j.pain.0000000000001171","volume":"159","author":"DS Albrecht","year":"2018","unstructured":"Albrecht, D. S. et al. Neuroinflammation of the spinal cord and nerve roots in chronic radicular pain patients. Pain 159(5), 968\u2013977. https:\/\/doi.org\/10.1097\/j.pain.0000000000001171 (2018).","journal-title":"Pain"},{"key":"6258_CR3","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.mehy.2017.06.014","volume":"105","author":"JNP Higgins","year":"2017","unstructured":"Higgins, J. N. P., Pickard, J. D. & Lever, A. M. L. Chronic fatigue syndrome and idiopathic intracranial hypertension: Different manifestations of the same disorder of intracranial pressure?. Med Hypotheses 105, 6\u20139. https:\/\/doi.org\/10.1016\/j.mehy.2017.06.014 (2017).","journal-title":"Med Hypotheses"},{"key":"6258_CR4","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.mehy.2017.12.006","volume":"110","author":"M Hulens","year":"2018","unstructured":"Hulens, M. et al. Fibromyalgia and unexplained widespread pain: The idiopathic cerebrospinal pressure dysregulation hypothesis. Med Hypotheses 110, 150\u2013154. https:\/\/doi.org\/10.1016\/j.mehy.2017.12.006 (2018).","journal-title":"Med Hypotheses"},{"issue":"S1","key":"6258_CR5","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s10072-015-2164-7","volume":"36","author":"R De Simone","year":"2015","unstructured":"De Simone, R. & Ranieri, A. The role of intracranial hypertension in the chronification of migraine. Neurol. Sci. 36(S1), 23\u201328. https:\/\/doi.org\/10.1007\/s10072-015-2164-7 (2015).","journal-title":"Neurol. Sci."},{"issue":"12","key":"6258_CR6","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1177\/0333102410370877","volume":"30","author":"F Bono","year":"2010","unstructured":"Bono, F. et al. Abnormal pressure waves in headache sufferers with bilateral transverse sinus stenosis. Cephalalgia 30(12), 1419\u20131425. https:\/\/doi.org\/10.1177\/0333102410370877 (2010).","journal-title":"Cephalalgia"},{"issue":"7","key":"6258_CR7","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1007\/s00415-014-7355-2","volume":"261","author":"R De Simone","year":"2014","unstructured":"De Simone, R. et al. Intracranial pressure in unresponsive chronic migraine. J. Neurol. 261(7), 1365\u20131373. https:\/\/doi.org\/10.1007\/s00415-014-7355-2 (2014).","journal-title":"J. Neurol."},{"key":"6258_CR8","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1056\/NEJMra010917","volume":"346","author":"PJ Goadsby","year":"2002","unstructured":"Goadsby, P. J., Lipton, R. B. & Ferrari, M. D. Migraine\u2014Current understanding and treatment. N. Engl. J. Med. 346, 257\u2013270. https:\/\/doi.org\/10.1056\/NEJMra010917 (2002).","journal-title":"N. Engl. J. Med."},{"key":"6258_CR9","doi-asserted-by":"publisher","first-page":"S44","DOI":"10.1016\/j.pain.2013.07.021","volume":"154","author":"R Noseda","year":"2013","unstructured":"Noseda, R. & Burstein, R. Migraine pathophysiology: Anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation SC12. Pain 154, S44\u2013S53 (2013).","journal-title":"Pain"},{"issue":"17","key":"6258_CR10","doi-asserted-by":"publisher","first-page":"6619","DOI":"10.1523\/jneurosci.0373-15.2015","volume":"35","author":"R Burstein","year":"2015","unstructured":"Burstein, R., Noseda, R. & Borsook, D. Migraine: Multiple processes, complex pathophysiology. J. Neurosci. 35(17), 6619\u20136629. https:\/\/doi.org\/10.1523\/jneurosci.0373-15.2015 (2015).","journal-title":"J. Neurosci."},{"issue":"8","key":"6258_CR11","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1007\/s00381-016-3143-x","volume":"32","author":"W Xu","year":"2016","unstructured":"Xu, W., Gerety, P., Aleman, T., Swanson, J. & Taylor, J. Noninvasive methods of detecting increased intracranial pressure. Child\u2019s Nervous Syst. 32(8), 1371\u20131386. https:\/\/doi.org\/10.1007\/s00381-016-3143-x (2016).","journal-title":"Child's Nervous Syst."},{"key":"6258_CR12","doi-asserted-by":"publisher","unstructured":"Mascarenhas, S. et al. The new ICP minimally invasive method shows that the Monro\u2013Kellie doctrine is not valid 117\u2013120. https:\/\/doi.org\/10.1007\/978-3-7091-0956-4_21 (2012).","DOI":"10.1007\/978-3-7091-0956-4_21"},{"key":"6258_CR13","first-page":"93","volume-title":"Validation of a New Noninvasive Intracranial Pressure Monitoring Method by Direct Comparison with an Invasive Technique","author":"B Cabella","year":"2016","unstructured":"Cabella, B. et al. Validation of a New Noninvasive Intracranial Pressure Monitoring Method by Direct Comparison with an Invasive Technique 93\u201396 (Springer, 2016)."},{"issue":"12","key":"6258_CR14","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.3390\/jpm11121302","volume":"11","author":"S Brasil","year":"2021","unstructured":"Brasil, S., Jorge, D., Solla, F., Nogueira, R. D. C. & Teixeira, M. J. A novel noninvasive technique for intracranial pressure waveform monitoring in critical care. J. Pers. Med. 11(12), 1302 (2021).","journal-title":"J. Pers. Med."},{"key":"6258_CR15","doi-asserted-by":"publisher","DOI":"10.1109\/JSEN.2021.3090648","author":"RDAP Andrade","year":"2021","unstructured":"Andrade, R. D. A. P. et al. A nanometer resolution wearable wireless medical device for non invasive intracranial pressure monitoring. IEEE Sens. J. https:\/\/doi.org\/10.1109\/JSEN.2021.3090648 (2021).","journal-title":"IEEE Sens. J."},{"key":"6258_CR16","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-59436-7_28","author":"I Gomes","year":"2021","unstructured":"Gomes, I. et al. Comparison of waveforms between noninvasive and invasive monitoring of intracranial pressure intracranial pressure and neuromonitoring XVII. Acta Neurochir. Suppl. https:\/\/doi.org\/10.1007\/978-3-030-59436-7_28 (2021).","journal-title":"Acta Neurochir. Suppl."},{"key":"6258_CR17","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-021-04834-y","author":"A Kazimierska","year":"2021","unstructured":"Kazimierska, A. et al. Compliance of the cerebrospinal space: Comparison of three methods. Acta Neurochir. https:\/\/doi.org\/10.1007\/s00701-021-04834-y (2021).","journal-title":"Acta Neurochir."},{"issue":"5","key":"6258_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/foc.2007.22.5.11","volume":"22","author":"M Czosnyka","year":"2007","unstructured":"Czosnyka, M. et al. Intracranial pressure: More than a number. FOC 22(5), 1\u20137 (2007).","journal-title":"FOC"},{"issue":"6","key":"6258_CR19","doi-asserted-by":"publisher","first-page":"545","DOI":"10.4037\/ajcc2008.17.6.545","volume":"17","author":"J-Y Fan","year":"2008","unstructured":"Fan, J.-Y., Kirkness, C., Vicini, P., Burr, R. & Mitchell, P. Intracranial pressure waveform morphology and intracranial adaptive capacity. Am. J. Crit. Care 17(6), 545\u2013554 (2008).","journal-title":"Am. J. Crit. Care"},{"issue":"5","key":"6258_CR20","doi-asserted-by":"publisher","first-page":"817","DOI":"10.3171\/jns.1983.59.5.0817","volume":"59","author":"ER Cardoso","year":"1983","unstructured":"Cardoso, E. R., Rowan, J. O. & Galbraith, S. Analysis of the cerebrospinal fluid pulse wave in intracranial pressure. J. Neurosurg. 59(5), 817\u2013821 (1983).","journal-title":"J. Neurosurg."},{"issue":"3","key":"6258_CR21","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s00701-015-2672-5","volume":"158","author":"CG Nucci","year":"2016","unstructured":"Nucci, C. G. et al. Intracranial pressure wave morphological classification: Automated analysis and clinical validation. Acta Neurochir. 158(3), 581\u2013588 (2016).","journal-title":"Acta Neurochir."},{"issue":"9","key":"6258_CR22","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1177\/0333102413485658","volume":"33","author":"Headache Classification Committee of the International Headache Society (IHS)","year":"2013","unstructured":"Headache Classification Committee of the International Headache Society (IHS). The international classification of headache disorders,3rd edition (beta version). Cephalalgia 33(9), 629\u2013808 (2013).","journal-title":"Cephalalgia"},{"key":"6258_CR23","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.2147\/JPR.S131479","volume":"10","author":"W Caumo","year":"2017","unstructured":"Caumo, W. et al. The central sensitization inventory validated and adapted for a Brazilian population: Psychometric properties and its relationship with brain-derived neurotrophic factor. J. Pain Res. 10, 2109\u20132122 (2017).","journal-title":"J. Pain Res."},{"issue":"3\u20134","key":"6258_CR24","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.anireprosci.2010.08.030","volume":"124","author":"M Mihm","year":"2011","unstructured":"Mihm, M., Gangooly, S. & Muttukrishna, S. The normal menstrual cycle in women. Anim. Reprod. Sci. 124(3\u20134), 229\u2013236 (2011).","journal-title":"Anim. Reprod. Sci."},{"issue":"4","key":"6258_CR25","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1590\/S1516-31802002000400006","volume":"120","author":"YD Fragoso","year":"2002","unstructured":"Fragoso, Y. D. MIDAS (Migraine disability assessment): A valuable tool for work-site identification of migraine in workers in Brazil. Sao Paulo Med. J. 120(4), 118\u2013121 (2002).","journal-title":"Sao Paulo Med. J."},{"issue":"11","key":"6258_CR26","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1590\/S0004-282X2012001100006","volume":"70","author":"LL Florencio","year":"2012","unstructured":"Florencio, L. L. et al. 12 item Allodynia Symptom Checklist\/Brasil: Cross-cultural adaptation, internal consistency and reproducibility. Arq Neuro-Psiquiatr. 70(11), 852\u2013856 (2012).","journal-title":"Arq Neuro-Psiquiatr."},{"issue":"11","key":"6258_CR27","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1111\/j.1526-4637.2012.01492.x","volume":"13","author":"F Sehn","year":"2012","unstructured":"Sehn, F. et al. Cross-cultural adaptation and validation of the Brazilian Portuguese version of the pain catastrophizing scale. Pain Med. 13(11), 1425\u20131435 (2012).","journal-title":"Pain Med."},{"issue":"4","key":"6258_CR28","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.rbp.2012.03.005","volume":"34","author":"MH Gomes-Oliveira","year":"2012","unstructured":"Gomes-Oliveira, M. H., Gorenstein, C., Neto, F. L., Andrade, L. H. & Wang, Y. P. Validation of the brazilian portuguese version of the beck depression inventory-II in a community sample. Rev. Bras. Psiquiatr. 34(4), 389\u2013394 (2012).","journal-title":"Rev. Bras. Psiquiatr."},{"key":"6258_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32162-0","author":"M Ashina","year":"2021","unstructured":"Ashina, M. et al. Migraine: Disease characterisation, biomarkers, and precision medicine. Lancet https:\/\/doi.org\/10.1016\/S0140-6736(20)32162-0 (2021).","journal-title":"Lancet"},{"key":"6258_CR30","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-021-00240-5","author":"S Ashina","year":"2021","unstructured":"Ashina, S., Bentivegna, E., Martelletti, P. & Eikermann-haerter, K. Structural and functional brain changes in migraine. Pain Ther. https:\/\/doi.org\/10.1007\/s40122-021-00240-5 (2021).","journal-title":"Pain Ther."},{"key":"6258_CR31","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1097\/01376517-200010000-00007","volume":"32","author":"CJ Kirkness","year":"2000","unstructured":"Kirkness, C. J., Mitchell, P. H., Burr, R. L., March, K. S. & Newell, D. W. Intracranial pressure waveform analysis: Clinical and research implications. J. Neurosci. Nurs. 32, 271\u2013277 (2000).","journal-title":"J. Neurosci. Nurs."},{"issue":"9","key":"6258_CR32","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1007\/s00381-017-3475-1","volume":"33","author":"MFM Ballestero","year":"2017","unstructured":"Ballestero, M. F. M., Frigieri, G., Cabella, B. C. T., de Oliveira, S. M. & de Oliveira, R. S. Prediction of intracranial hypertension through noninvasive intracranial pressure waveform analysis in pediatric hydrocephalus. Childs Nerv Syst. 33(9), 1517\u20131524 (2017).","journal-title":"Childs Nerv Syst."},{"key":"6258_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnins.2021.601945","volume":"15","author":"G Paraguassu","year":"2021","unstructured":"Paraguassu, G., Khilnani, M. & Rabelo, N. N. Case report: Untreatable headache in a child with ventriculoperitoneal shunt managed by use of new non-invasive intracranial pressure waveform. Front. Neurosci. 15, 1\u20134 (2021).","journal-title":"Front. Neurosci."},{"key":"6258_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0240570","author":"C Rickli","year":"2021","unstructured":"Rickli, C. et al. Use of non-invasive intracranial pressure pulse waveform to monitor patients with End-Stage Renal Disease (ESRD). PLoS ONE https:\/\/doi.org\/10.1371\/journal.pone.0240570 (2021).","journal-title":"PLoS ONE"},{"issue":"493","key":"6258_CR35","first-page":"1","volume":"12","author":"TM Dhaese","year":"2021","unstructured":"Dhaese, T. M., Welling, L. C., Kosciasnki, A. M., Frigeri, G. & Auada, J. Non-invasive intracranial pressure monitoring in idiopathic intracranial hypertension and lumbar puncture in pediatric patient: Case report. Surg. Neurol. Int. 12(493), 1\u20134 (2021).","journal-title":"Surg. Neurol. Int."},{"key":"6258_CR36","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/j.1468-2982.2008.01727.x","volume":"29","author":"SH B\u00f8","year":"2009","unstructured":"B\u00f8, S. H. et al. Cerebrospinal fluid cytokine levels in migraine, tension-type headache and cervicogenic headache. Cephalalgia 29, 365\u2013372 (2009).","journal-title":"Cephalalgia"},{"key":"6258_CR37","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jneuroim.2011.10.013","volume":"242","author":"D Kadetoff","year":"2012","unstructured":"Kadetoff, D., Lampa, J., Westman, M., Andersson, M. & Kosek, E. Evidence of central inflammation in fibromyalgia\u2014Increased cerebrospinal fluid interleukin-8 levels. J. Neuroimmunol. 242, 33\u201338. https:\/\/doi.org\/10.1016\/j.jneuroim.2011.10.013 (2012).","journal-title":"J. Neuroimmunol."},{"key":"6258_CR38","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.64.10_suppl_2.S9","author":"C Waeber","year":"2005","unstructured":"Waeber, C. & Moskowitz, M. A. Migraine as an inflammatory disorder. Neurology https:\/\/doi.org\/10.1212\/WNL.64.10_suppl_2.S9 (2005).","journal-title":"Neurology"},{"key":"6258_CR39","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/s41582-019-0216-y","volume":"15","author":"L Edvinsson","year":"2019","unstructured":"Edvinsson, L., Haanes, K. A. & Warfvinge, K. Does inflammation have a role in migraine?. Nat. Rev. Neurol. 15, 483\u2013490 (2019).","journal-title":"Nat. Rev. Neurol."},{"issue":"7","key":"6258_CR40","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1097\/j.pain.0000000000001531","volume":"160","author":"KP Peng","year":"2019","unstructured":"Peng, K. P. & May, A. Migraine understood as a sensory threshold disease. Pain 160(7), 1494\u20131501 (2019).","journal-title":"Pain"},{"issue":"5","key":"6258_CR41","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1590\/0004-282X-ANP-2020-0300","volume":"79","author":"MFM De","year":"2020","unstructured":"De, M. F. M. & Silva, G. S. Noninvasive intracranial pressure monitoring methods: A critical review. Arq. Neuropsiquiatr. 79(5), 437\u2013446. https:\/\/doi.org\/10.1590\/0004-282X-ANP-2020-0300 (2020).","journal-title":"Arq. Neuropsiquiatr."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-06258-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-06258-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-06258-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T23:29:51Z","timestamp":1669332591000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-06258-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,16]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["6258"],"URL":"https:\/\/doi.org\/10.1038\/s41598-022-06258-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,16]]},"assertion":[{"value":"18 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.\u00a0FJT declares personal fees as employee\u00a0from Braincare Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica S.A., during the conduct of the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2635"}}