{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:22:41Z","timestamp":1792790561777,"version":"4.5.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inflammatory states are associated with anemia of chronic disease and acute infection. Hepcidin, a regulator of iron metabolism, is involved in iron pathophysiology during inflammation. We investigated biochemical characteristics in children with anemia from different causes. Four patient groups (n\u2009=\u200938; mean age: 12.44\u2009\u00b1\u20094.35\u00a0years) were studied: (1) inflammatory bowel disease (IBD, 10 patients); (2) iron deficiency anemia (IDA, 12); (3) celiac disease (CD, 8); (4) acute infection (AI, 8). Laboratory measurements were evaluated at diagnosis: blood count, serum iron, transferrin, ferritin, vitamin B<jats:sub>12<\/jats:sub>, folic acid, CRP, erythropoietin, hepcidin and soluble transferrin receptor (sTfR). IDA patients had the lowest Hgb (6.9\u2009\u00b1\u20091.7\u00a0g\/dL), MCV (63.2\u2009\u00b1\u20097.2 fL), iron (16.8\u2009\u00b1\u200913.5\u00a0\u00b5g\/dL), ferritin (4.5\u2009\u00b1\u20094.5\u00a0ng\/mL) and hepcidin (3.1\u2009\u00b1\u20090.8\u00a0ng\/mL) values, and the highest transferrin and sTfR values. AI patients had the highest ferritin (156.2\u2009\u00b1\u2009124.5\u00a0ng\/mL), CRP (144.6\u2009\u00b1\u200994\u00a0mg\/L) and hepcidin (74.67\u2009\u00b1\u200912.3\u00a0ng\/ml) values. Overall, hepcidin levels correlated with CRP and with ferritin (r\u2009=\u20090.83 and 0.85, respectively). Elucidating specific etiology-related biochemical profiles in pediatric patients with anemia from different causes using a combination of laboratory biomarkers, including hepcidin, can help physicians treat the anemia.<\/jats:p>","DOI":"10.1038\/s41598-022-06574-0","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T11:02:53Z","timestamp":1645095773000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Characterization of acquired anemia in children by iron metabolism parameters"],"prefix":"10.1038","volume":"12","author":[{"given":"Yael","family":"Ben-David","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Koren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Colodner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"6574_CR1","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.3324\/haematol.2018.205575","volume":"103","author":"C Hershko","year":"2018","unstructured":"Hershko, C. 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