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We aimed to identify metabolite alterations across a collegiate American football season. Serum was collected from 23 male collegiate football athletes before the athletic season (\n                    <jats:italic>Pre<\/jats:italic>\n                    ) and after the last game (\n                    <jats:italic>Post<\/jats:italic>\n                    ). Samples underwent nontargeted metabolomic profiling and 1131 metabolites were included for univariate, pathway enrichment, and multivariate analyses. Significant metabolites were assessed against head acceleration events (HAEs). 200 metabolites changed from\n                    <jats:italic>Pre<\/jats:italic>\n                    to\n                    <jats:italic>Post<\/jats:italic>\n                    (P\u2009&lt;\u20090.05 and Q\u2009&lt;\u20090.05); 160 had known identity and mapped to one of 57 pre-defined biological pathways. There was significant enrichment of metabolites belonging to five pathways (P\u2009&lt;\u20090.05): xanthine, fatty acid (acyl choline), medium chain fatty acid, primary bile acid, and glycolysis, gluconeogenesis, and pyruvate metabolism. A set of 12 metabolites was sufficient to discriminate\n                    <jats:italic>Pre<\/jats:italic>\n                    from\n                    <jats:italic>Post<\/jats:italic>\n                    status, and changes in 64 of the 200 metabolites were also associated with HAEs (P\u2009&lt;\u20090.05). In summary, the identified metabolites, and candidate pathways, argue there are metabolic consequences of both physical training and head impacts with football participation. These findings additionally identify a potential set of objective biomarkers of repetitive head injury.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-07079-6","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T06:05:25Z","timestamp":1645596325000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Metabolomic response to collegiate football participation: Pre- and Post-season analysis"],"prefix":"10.1038","volume":"12","author":[{"given":"Nicole L.","family":"Vike","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumra","family":"Bari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khrystyna","family":"Stetsiv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Talavage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Nauman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Papa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semyon","family":"Slobounov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans C.","family":"Breiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn C.","family":"Cornelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"7079_CR1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1080\/87565641.2015.1016161","volume":"40","author":"EA Nauman","year":"2015","unstructured":"Nauman, E. 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