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A surveillance study was performed in the largest tertiary care hospital in Kuala Lumpur, Malaysia, from 2018 to 2020 to observe the trends of broad-spectrum antibiotics (beta-lactam\/beta-lactamases inhibitors (BL\/BLI), extended-spectrum cephalosporins (ESC), and fluoroquinolones (FQ)) and antibiotics against MRO\u00a0(carbapenems, polymyxins, and glycopeptides) usage and the correlation between antibiotic consumption and MROs. The correlation between 3-year trends of antibiotic consumption (defined daily dose (DDD)\/100 admissions) with MRO infection cases (per 100 admissions) was determined using a Jonckheere-Terpstra test and a Pearson\u2019s Correlation coefficient. The antimicrobial resistance trend demonstrated a positive correlation between ESC and FQ towards the development of methicillin-resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA), extended-spectrum beta-lactamase (ESBL)-producing\n                    <jats:italic>Klebsiella<\/jats:italic>\n                    spp, ESBL-producing\n                    <jats:italic>Escherichia coli (E. coli),<\/jats:italic>\n                    and MRO\n                    <jats:italic>Acinetobacter baumannii (A. baumannii)<\/jats:italic>\n                    . Increasing carbapenem consumption was positively correlated with the occurrence of ESBL-producing\n                    <jats:italic>Klebsiella spp<\/jats:italic>\n                    and\n                    <jats:italic>E. coli<\/jats:italic>\n                    . Polymyxin use was positively correlated with ESBL-producing\n                    <jats:italic>Klebsiella spp<\/jats:italic>\n                    , MRO\n                    <jats:italic>A. baumannii,<\/jats:italic>\n                    and carbapenem-resistant Enterobacteriaceae. The findings reinforced concerns regarding the association between MRO development, especially with a surge in ESC and FQ consumption. Stricter use of antimicrobials is thus crucial to minimise the risk of emerging resistant organisms.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-07142-2","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T06:02:48Z","timestamp":1645682568000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Correlation between antibiotic consumption and the occurrence of multidrug-resistant organisms in a Malaysian tertiary hospital: a 3-year observational study"],"prefix":"10.1038","volume":"12","author":[{"given":"Sin Yee","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahela Ambaras","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khairil Erwan","family":"Khalid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Wie","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athirah","family":"Bakhtiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"issue":"2","key":"7142_CR1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.4161\/viru.22507","volume":"4","author":"IM Gould","year":"2013","unstructured":"Gould, I. 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