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Macular volume scans were acquired using spectral-domain optical coherence tomography with enhanced depth imaging. CVI was assessed based on B-scan binarisation and choroid segmentation. The 3D CVI of the whole, superior, central, and inferior macula were 62.92\u2009\u00b1\u20091.57%, 62.75\u2009\u00b1\u20091.93%, 63.35\u2009\u00b1\u20091.72%, and 62.66\u2009\u00b1\u20091.70%, respectively, pairwise comparisons P all\u2009&gt;\u20090.05). 3D CVI (Whole Macula) and 2D CVI (Subfoveal) were associated only with each other and not with other ocular and systemic factors. 2D CVI (Subfoveal) had a moderate agreement with 3D CVI (Central Macula) [intraclass corelation coefficient (ICC)\u2009=\u20090.719], and had poorer agreement with 3D CVI of the whole macula, superior, and inferior macula (ICC\u2009=\u20090.591, 0.483, and 0.394, respectively). Scanning volume did not influence 3D CVI measurements. In conclusion, 3D CVI demonstrated no significant topographic variation. CVI was not correlated with demographic or ocular structural features. 2D CVI of the fovea is partially representative of 3D CVI of the macula.\n<\/jats:p>","DOI":"10.1038\/s41598-022-07510-y","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T11:03:12Z","timestamp":1646823792000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Three-dimensional modelling of the choroidal angioarchitecture in a multi-ethnic Asian population"],"prefix":"10.1038","volume":"12","author":[{"given":"Kai Xiong","family":"Cheong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin Yi Chong","family":"Teo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih Chung","family":"Tham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralene","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Majithia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Cheng Sim","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Yu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chui Ming Gemmy","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupesh","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"7510_CR1","doi-asserted-by":"publisher","first-page":"100829","DOI":"10.1016\/j.preteyeres.2020.100829","volume":"77","author":"R Agrawal","year":"2020","unstructured":"Agrawal, R. et al. 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