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This study calculated the transmissibility of HFMD at county levels in Jiangsu Province, China, analyzed the differences of transmissibility and explored the possible influencing factors of its transmissibility. We built a mathematical model for seasonal characteristics of HFMD, estimated the effective reproduction number (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>eff<\/jats:italic>\n                    <\/jats:sub>\n                    ), and compared the incidence rate and transmissibility in different counties using non-parametric tests, rapid cluster analysis and rank-sum ratio in 97 counties in Jiangsu Province from 2015 to 2020. The average daily incidence rate was between 0 and 4 per 100,000 people in Jiangsu Province from 2015\u20132020. The Quartile of\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>eff<\/jats:italic>\n                    <\/jats:sub>\n                    in Jiangsu Province from 2015 to 2020 was 1.54 (0.49, 2.50). Rugao District and Jianhu District had the highest transmissibility according to the rank-sum ratio.\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>eff<\/jats:italic>\n                    <\/jats:sub>\n                    generally decreased in 2017 and increased in 2018 in most counties, and the median level of\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>eff<\/jats:italic>\n                    <\/jats:sub>\n                    was the lowest in 2017 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). The transmissibility was different in 97 counties in Jiangsu Province. The reasons for the differences may be related to the climate, demographic characteristics, virus subtypes, vaccination, hygiene and other infectious diseases.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-07982-y","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T11:25:37Z","timestamp":1646738737000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Transmissibility of hand, foot, and mouth disease in 97 counties of China"],"prefix":"10.1038","volume":"12","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Rui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lexin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simiao","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junru","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XingCheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhua","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benhua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-li","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianmu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"7982_CR1","doi-asserted-by":"publisher","first-page":"537","DOI":"10.3949\/ccjm.81a.13132","volume":"81","author":"GL Repass","year":"2014","unstructured":"Repass, G. 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