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HydroZitLa contains citrate and natural antioxidants and is developed to correct these three factors simultaneously. Antioxidants theoretically can prolong the lifespan of organisms. In this study, we preclinically investigated the antilithogenic, lifespan-extending and anti-aging effects of HydroZitLa in HK-2 cells, male Wistar rats, and\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    . HydroZitLa significantly inhibited CaOx crystal aggregation in vitro and reduced oxidative stress in HK-2 cells challenged with lithogenic factors. For experimental nephrolithiasis, rats were divided into four groups: ethylene glycol (EG), EG\u2009+\u2009HydroZitLa, EG\u2009+\u2009Uralyt-U, and untreated control. CaOx deposits in kidneys of EG\u2009+\u2009HydroZitLa and EG\u2009+\u2009Uralyt-U rats were significantly lower than those of EG rats. Intrarenal expression of 4-hydroxynonenal in EG\u2009+\u2009HydroZitLa rats was significantly lower than that of EG rats. The urinary oxalate levels of EG\u2009+\u2009HydroZitLa and EG\u2009+\u2009Uralyt-U rats were significantly lower than those of EG rats. The urinary citrate levels of EG\u2009+\u2009HydroZitLa and EG\u2009+\u2009Uralyt-U rats were restored to the level in normal control rats. In\n                    <jats:italic>C. elegans<\/jats:italic>\n                    , HydroZitLa supplementation significantly extended the median lifespan of nematodes up to 34% without altering feeding ability. Lipofuscin accumulation in HydroZitLa-supplemented nematodes was significantly lower than that of non-supplemented control. Additionally, HydroZitLa inhibited telomere shortening, p16 upregulation, and premature senescence in HK-2 cells exposed to lithogenic stressors. Conclusions, HydroZitLa inhibited oxidative stress and CaOx formation both in vitro and in vivo. HydroZitLa extended the lifespan and delayed the onset of aging in\n                    <jats:italic>C. elegans<\/jats:italic>\n                    and human kidney cells. This preclinical evidence suggests that HydroZitLa is beneficial for inhibiting CaOx stone formation, promoting longevity, and slowing down aging.\n                  <\/jats:p>","DOI":"10.1038\/s41598-022-08316-8","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T07:47:03Z","timestamp":1648194423000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["HydroZitLa inhibits calcium oxalate stone formation in nephrolithic rats and promotes longevity in nematode Caenorhabditis elegans"],"prefix":"10.1038","volume":"12","author":[{"given":"Nalinthip","family":"Lordumrongkiat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nattida","family":"Chotechuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mani Iyer","family":"Prasanth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Depicha","family":"Jindatip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chakriwong","family":"Ma-on","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamonchanok","family":"Chuenwisad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asada","family":"Leelahavanichkul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tewin","family":"Tencomnao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanchai","family":"Boonla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"8316_CR1","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1177\/014107688908201112","volume":"82","author":"AR Michell","year":"1989","unstructured":"Michell, A. 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