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Here we are focusing on the development of a novel anti-malarial and virucidal agent with biocidal effects also on its vectors. We have synthesized a new quinoline (4,7-dichloroquinoline) derivative which showed significant larvicidal and pupicidal properties against a malarial and a dengue vector and a lethal toxicity ranging from 4.408\u00a0\u00b5M\/mL (first instar larvae) to 7.958\u00a0\u00b5M\/mL (pupal populations) for <jats:italic>Anopheles stephensi<\/jats:italic> and 5.016\u00a0\u00b5M\/mL (larva 1) to 10.669\u00a0\u00b5M\/mL (pupae) for <jats:italic>Aedes aegypti<\/jats:italic>. <jats:italic>In-vitro<\/jats:italic> antiplasmodial efficacy of 4,7-dichloroquinoline revealed a significant growth inhibition of both sensitive strains of <jats:italic>Plasmodium falciparum<\/jats:italic> with IC<jats:sub>50<\/jats:sub> values of 6.7\u00a0nM (CQ-s) and 8.5\u00a0nM (CQ-r). Chloroquine IC<jats:sub>50<\/jats:sub> values, as control, were 23\u00a0nM (CQ-s), and 27.5\u00a0nM (CQ-r). In vivo antiplasmodial studies with <jats:italic>P. falciparum<\/jats:italic> infected mice showed an effect of 4,7-dichloroquinoline compared to chloroquine. The quinoline compound showed significant activity against the viral pathogen serotype 2 (DENV-2). In vitro conditions and the purified quinoline exhibited insignificant toxicity on the host system up to 100\u00a0\u00b5M\/mL. Overall, 4,7-dichloroquinoline could provide a good anti-vectorial and anti-malarial agent.<\/jats:p>","DOI":"10.1038\/s41598-022-08397-5","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T13:02:41Z","timestamp":1647694961000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Synthesis of new series of quinoline derivatives with insecticidal effects on larval vectors of malaria and dengue diseases"],"prefix":"10.1038","volume":"12","author":[{"given":"Kadarkarai","family":"Murugan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chellasamy","family":"Panneerselvam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayapal","family":"Subramaniam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manickam","family":"Paulpandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajapandian","family":"Rajaganesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murugan","family":"Vasanthakumaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagannathan","family":"Madhavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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