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A retrospective study included 106 infants with a birth weight of\u2009&lt;\u20091500\u00a0g who were born at King Saud Medical City at\u2009\u2264\u200932 gestational weeks, were admitted to the neonatal intensive care unit, and underwent term-equivalent age or pre-discharge brain MRI. A univariate analysis in addition to modified log-Poisson regression with a robust variance estimator was applied, and the effect of early morphine exposure and cumulative dose in the first seven days on brain morphology and growth at term-equivalent age was determined using the Kidokoro score. Sixty-eight (64.2%) infants had received morphine in the first week of life (median cumulative dose: 1.68\u00a0mg\/kg, interquartile range 0.48\u20132.52\u00a0mg\/kg). Early initiation of morphine administration was significantly associated with high total white matter (adjusted relative risk [aRR] 1.32, 95% confidence interval [CI] 1.01\u20131.72) and cerebellum (aRR 1.36, 95% CI 1.03\u20131.81) scores and a small cerebellar volume (aRR 1.28, 95% CI 1.02\u20131.61). Morphine exposure in the first week of life was independently associated with white matter and cerebellar injury on term-equivalent age brain MRI in very preterm infants.<\/jats:p>","DOI":"10.1038\/s41598-022-08677-0","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T11:04:04Z","timestamp":1647428644000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association between morphine exposure and impaired brain development on term-equivalent age brain magnetic resonance imaging in very preterm infants"],"prefix":"10.1038","volume":"12","author":[{"given":"Mountasser M.","family":"Al-Mouqdad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dima Z.","family":"Jamjoom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roya","family":"Huseynova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanaa M.","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmeen S.","family":"Asfour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra A.","family":"Albeshri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia A.","family":"Basodan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuddah","family":"Assiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan S.","family":"Asfour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"8677_CR1","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1056\/NEJM198711193172105","volume":"21","author":"KJ Anand","year":"1987","unstructured":"Anand, K. 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