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Pathological elevation in ICP results in structural damage through various mechanisms, which adversely affects outcomes in traumatic brain injury and stroke. Currently, invasive procedures which tap directly into the cerebrospinal fluid are required to measure this pressure. Recent fluidic engineering modelling analogous to the ocular vascular flow suggests that retinal venous pulse amplitudes are predictably influenced by downstream pressures, suggesting that ICP could be estimated by analysing this pulse signal. We used this modelling theory and our photoplethysmographic (PPG) retinal venous pulse amplitude measurement system to measure amplitudes in 30 subjects undergoing invasive ICP measurements by lumbar puncture (LP) or external ventricular drain (EVD). We estimated ICP from these amplitudes using this modelling and found it to be accurate with a mean absolute error of 3.0\u00a0mmHg and a slope of 1.00 (r\u2009=\u20090.91). Ninety-four percent of differences between the PPG and invasive method were between \u2212\u20095.5 and +\u20094.0\u00a0mmHg, which compares favourably to comparisons between LP and EVD. This type of modelling may be useful for understanding retinal vessel pulsatile fluid dynamics and may provide a method for non-invasive ICP measurement.<\/jats:p>","DOI":"10.1038\/s41598-022-09151-7","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T15:16:35Z","timestamp":1648221395000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Zero retinal vein pulsation amplitude extrapolated model in non-invasive intracranial pressure estimation"],"prefix":"10.1038","volume":"12","author":[{"given":"W. 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The Lions Eye Institute owns the patents. WH Morgan\u2014patent inventor, NHMRC grant recipient; YJ Khoo\u2014no competing interests; A Vukmirovic\u2014no competing interests; A Rahman\u2014holds patent in related field; AG Kermode\u2014no competing interests; CR Lind\u2014no competing interests; J Dunuwille\u2014no competing interests; DY Yu\u2014patent inventor, NHMRC grant recipient.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"5190"}}