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Routinely collected hospital data provide opportunities to identify clinically relevant PFs and construct accurate prognostic models without additional data-collection costs. This multicenter (66 hospitals) study reports on associations various patient-level variables have with outcomes and costs. Outcomes were in-hospital mortality, intensive care unit (ICU) admission, length of stay, 30-day readmission, 30-day reintervention and in-hospital costs. Candidate PFs were age, sex, Elixhauser Comorbidity Score, prior hospitalizations, prior days spent in hospital, and socio-economic status. Included patients dealt with either colorectal carcinoma (CRC, n\u2009=\u200910,254), urinary bladder carcinoma (UBC, n\u2009=\u200917,385), acute percutaneous coronary intervention (aPCI, n\u2009=\u200925,818), or total knee arthroplasty (TKA, n\u2009=\u200939,214). Prior hospitalization significantly increased readmission risk in all treatments (OR between 2.15 and 25.50), whereas prior days spent in hospital decreased this risk (OR between 0.55 and 0.95). In CRC patients, women had lower risk of in-hospital mortality (OR 0.64), ICU admittance (OR 0.68) and 30-day reintervention (OR 0.70). Prior hospitalization was the strongest PF for higher costs across all treatments (31\u201364% costs increase\/hospitalization). Prognostic model performance (c-statistic) ranged 0.67\u20130.92, with Brier scores below 0.08. R-squared ranged from 0.06\u20130.19 for LoS and 0.19\u20130.38 for costs. Identified PFs should be considered as building blocks for treatment-specific prognostic models and information for monitoring patients after surgery. 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